Age-related aspects of glioma: current understanding. Literature review DOI Creative Commons
S. P. Lugovskyi, Tatyana Kvitnitskaya-Ryzhova

Ukrainian Neurosurgical Journal, Год журнала: 2024, Номер 30(4), С. 11 - 22

Опубликована: Дек. 30, 2024

The updated 2021 WHO Classification of Central Nervous System (CNS) Tumors introduces, for the first time, an age-based approach to glioma classification, leveraging advances in molecular biology and epigenetics CNS tumors. This classification groups gliomas within category "Gliomas, glioneuronal tumors, neuronal tumors," distinguishing between adult-type pediatric-type diffuse gliomas, corresponding low-grade high-grade malignancies (LGG HGG), highlighting fundamental role age gliomagenesis. A review current literature deepens understanding age-related characteristics, differences, patterns gliomagenesis across groups, which is essential effective diagnosis treatment. Pediatric-type (pLGG aLGG) differ location, biological behavior, molecular-genetic profiles. Inherited syndromes (e.g., NF-1, TSC) associated with development are linked specific LGG subtypes occurring childhood, adolescence, adulthood. Moreover, pLGG differs from aLGG its potential malignant transformation spontaneous regression, as well mutations affecting MAPK (mitogen-activated protein kinase) pathway. While (pHGG aHGG) share histological features, they profiles, prognosis. major distinction aHGG pHGG lies such IDH 1/2, EGFR gene expression, TERT mutations, chromosome alterations (+7/-10), TP53 all contributing a poorer prognosis HGG gliomas. Additionally, changes histone proteins H3.3 or 3.1 (H3.3 K27 H3 G34) pHGG, opposed aHGG, carry diagnostic prognostic significance. An analysis data on epidemiology, risk factors, characteristic features considering provided. next publication will cover certain clinical aspects this issue.

Язык: Английский

The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis DOI
Payam Behzadi, Deepak Chandran, Chiranjib Chakraborty

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137836 - 137836

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

7
The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19 DOI Creative Commons

Reyhaneh Niayesh‐Mehr,

Mojtaba Kalantar, Giulio Bontempi

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Язык: Английский

Процитировано

4
SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB DOI Creative Commons
Vittoria Monaco, Ilaria Iacobucci, Luisa Canè

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134638 - 134638

Опубликована: Авг. 13, 2024

Язык: Английский

Процитировано

3
Role of furin in the severity of COVID-19 infection via effects on miR-20b and miR-106a DOI
Ismail Sami Mahmoud, Amr E. Ahmed, Olfat Shaker

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0
Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? DOI Creative Commons
Senthil Kumaran Satyanarayanan, Tsz Fung Yip,

Zixu Han

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

In the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in innate immune response, possess ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, well resulting damage-associated patterns (DAMPs), endogenous molecules released after cellular damage. A developing perspective suggests that TLRs central neuroinflammation, fundamental factor neurodegenerative conditions like Alzheimer’s Parkinson’s disease (PD). comprehensive review consolidates current research investigating potential interplay TLRs, their signaling mechanisms, processes neurodegeneration following SARS-CoV-2 infection with an aim elucidate involvement long-term neurological complications COVID-19 explore targeting means implementing intervention strategies for prevention or treatment COVID-19-associated brain outcomes.

Язык: Английский

Процитировано

0
In-depth analysis of the risk factors for persistent severe acute respiratory syndrome coronavirus 2 infection and construction of predictive models: an exploratory research study DOI Creative Commons
Jia Zhang, Weihua Zhu,

Piping Jiang

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Май 14, 2025

Язык: Английский

Процитировано

0
A survey of SARS-CoV-2 tropism DOI Creative Commons

Xiangxing Jin,

Xiang Ren, Xianwen Ren

и другие.

Infectious Diseases & Immunity, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has significantly burdened global public health. However, the tropism of SARS-CoV-2 within human body remains not fully understood. In this review, we overview literature on infection across various organs and tissues. We summarize relevant specimen types, techniques for examining tropism, findings at both organ/tissue cellular levels. To systematically evaluate evidence supporting tissue establish a hierarchical classification system based two key criteria: (1) origin (2) detection methodology. Clinical specimens obtained directly from COVID-19 patients provide most definitive evidence, whereas organoid-derived animal models indicate potential infectivity under artificial conditions. terms methods, prioritize viral particle identification over protein or RNA detection, as latter requires further confirmation to productive infection. Our that potentially targets multiple organ systems, including tract, lungs, kidneys, heart, blood vessels, pancreas, small intestine, liver, salivary glands. By contrast, central nervous reproductive uncertain validation. At level, identify specific target cell types vulnerable infection, ciliated epithelial cells, alveolar type II pneumocytes, enterocytes, cardiomyocytes, vascular endothelial renal tubular pancreatic acinar cells. Furthermore, analyze correlation between angiotensin-converting enzyme receptor distribution patterns well variations in specificity among different variants. expect review comprehensive landscape enhance our understanding life cycle consequences body.

Язык: Английский

Процитировано

0
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models DOI Creative Commons
Maritza Puray‐Chavez, Jenna E. Eschbach, Ming Xia

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 27, 2024

Host factors that define the cellular tropism of SARS-CoV-2 beyond cognate ACE2 receptor are poorly defined. Here we report replication is restricted at a post-entry step in number ACE2-positive airway-derived cell lines due to tonic activation cGAS-STING pathway mediated by mitochondrial DNA leakage and naturally occurring cGAS STING variants. Genetic pharmacological inhibition type I/III IFN pathways as well overexpression overcome these blocks. knockout primary airway cultures induces ISG expression but only uninfected bystander cells, demonstrating efficient antagonism IFN-pathway productively infected cells. Pharmacological cells enhances reduces virus-induced innate immune activation. Together, our study highlights can impact manner dependent on levels.

Язык: Английский

Процитировано

1
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models DOI Creative Commons
Maritza Puray‐Chavez, Jenna E. Eschbach, Ming Xia

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 8, 2024

ABSTRACT Host factors that define the cellular tropism of SARS-CoV-2 beyond cognate ACE2 receptor are poorly defined. Here we report replication is restricted at a post-entry step in number ACE2-positive airway-derived cell lines due to tonic activation cGAS-STING pathway mediated by mitochondrial DNA leakage and naturally occurring cGAS STING variants. Genetic pharmacological inhibition type I/III IFN pathways as well overexpression overcome these blocks. knockout primary airway cultures induces ISG expression but only uninfected bystander cells, demonstrating efficient antagonism IFN-pathway productively infected cells. Pharmacological cells enhances reduces virus-induced innate immune activation. Together, our study highlights can impact manner dependent on levels.

Язык: Английский

Процитировано

0
Age-related aspects of glioma: current understanding. Literature review DOI Creative Commons
S. P. Lugovskyi, Tatyana Kvitnitskaya-Ryzhova

Ukrainian Neurosurgical Journal, Год журнала: 2024, Номер 30(4), С. 11 - 22

Опубликована: Дек. 30, 2024

The updated 2021 WHO Classification of Central Nervous System (CNS) Tumors introduces, for the first time, an age-based approach to glioma classification, leveraging advances in molecular biology and epigenetics CNS tumors. This classification groups gliomas within category "Gliomas, glioneuronal tumors, neuronal tumors," distinguishing between adult-type pediatric-type diffuse gliomas, corresponding low-grade high-grade malignancies (LGG HGG), highlighting fundamental role age gliomagenesis. A review current literature deepens understanding age-related characteristics, differences, patterns gliomagenesis across groups, which is essential effective diagnosis treatment. Pediatric-type (pLGG aLGG) differ location, biological behavior, molecular-genetic profiles. Inherited syndromes (e.g., NF-1, TSC) associated with development are linked specific LGG subtypes occurring childhood, adolescence, adulthood. Moreover, pLGG differs from aLGG its potential malignant transformation spontaneous regression, as well mutations affecting MAPK (mitogen-activated protein kinase) pathway. While (pHGG aHGG) share histological features, they profiles, prognosis. major distinction aHGG pHGG lies such IDH 1/2, EGFR gene expression, TERT mutations, chromosome alterations (+7/-10), TP53 all contributing a poorer prognosis HGG gliomas. Additionally, changes histone proteins H3.3 or 3.1 (H3.3 K27 H3 G34) pHGG, opposed aHGG, carry diagnostic prognostic significance. An analysis data on epidemiology, risk factors, characteristic features considering provided. next publication will cover certain clinical aspects this issue.

Язык: Английский

Процитировано

0