Carbohydrate Polymers, Год журнала: 2024, Номер 352, С. 123201 - 123201
Опубликована: Дек. 30, 2024
Язык: Английский
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Сен. 26, 2024
Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.
Язык: Английский
Процитировано
9
Carcinogenesis, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Abstract Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but results are contradictory. This study aimed to conduct a systematic review and meta-analysis investigate measured in two biological matrices (serum/plasma/blood tissue) dietary intake CRC patients compared healthy controls. We conducted comprehensive search PubMed, Scopus, Embase Web of Science. included that reported levels serum/plasma/blood, tissue or from diet, with observational design (cohort case-control studies). Study quality was assessed Newcastle-Ottawa scale potential causes heterogeneity were evaluated. Standardized mean differences (SMD) 95% confidence interval (CI) pooled using random-effect models. Overall Odds Ratio CI for risk calculated. Twenty-six (23 3 cohort studies) total 227,354 participants included. Most presented low (50%) moderate (42.3%). No serum/plasma/blood (SMD=0.23; 95%CI -0.23, 0.70; I2=97.3%, 19 studies), (SMD=-1.69; -3.41, 0.03; I2=85.6%, 2 copper/zinc ratio (SMD=1.19; 0.54, 1.84; I2=95.3%, 6 found Regarding copper, had lower (SMD=-0.27; -0.51, -0.03; I2=0.0%, However, evidence shows mostly quality, heterogeneous. More prospective an adequate methodological approach needed.
Язык: Английский
Процитировано
1
Environmental and Sustainability Indicators, Год журнала: 2024, Номер 22, С. 100396 - 100396
Опубликована: Апрель 23, 2024
Crop intensification has increased as human population growth drives the demand for food. However, urbanization, industrialization, and contamination of soil by heavy metal (HM) have become significant challenges to agricultural production. Urbanization activities jeopardize harm health, which is critical environment, ecosystems, sustainable agriculture, global economy. Smelting, mining, other industrial that release toxic HMs into environment significantly reduce with serious consequences both plants humans. Furthermore, achievement agriculture severely inhibited presence HM in soil. Hence, combat subsequent reduction crop output brought on contamination, it necessary engage suitable microbes remove these pollutants. This will result a more productive safety foods, realization food security. Therefore, this study explored efficacy, advantages, limitations current conventional methods remediation well potential like Pseudomonas aeruginosa, Vibrio parahaemolyticus, Alyxia rubricaulis, Maytenus bureaviana reclamation polluted agriculture. Employing natural non-hazardous contaminants, highlighted review, would help improve health quality, increase production, promote outlined United Nations' Sustainable Development Goals.
Язык: Английский
Процитировано
5
Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111394 - 111394
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biochemistry and Biophysics Reports, Год журнала: 2025, Номер 42, С. 101983 - 101983
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(13), С. 2053 - 2053
Опубликована: Июнь 27, 2024
Trace elements are essential for several physiological processes. To date, various data have suggested that inadequate levels of trace may be involved in the pathogenesis different chronic diseases, including immune-mediated ones, or develop during their course. Systemic sclerosis (SSc) is a complex autoimmune multisystemic disease, primarily characterized by microvascular dysregulation, widespread activation immune system and tissue fibrosis. According to latest reports regarding SSc, main pathophysiological processes—inflammation, vasculopathy fibrosis—may include element derangements. The present literature review aims update available iron, zinc, copper selenium status SSc as well underline possible implications these complexity pathogenic process disease. We observe plays crucial role numerous processes, emphasizing necessity proper monitoring supplementation. reported heterogenous scarce, future studies needed order draw clearer conclusions about complete spectrum.
Язык: Английский
Процитировано
2
Journal of Orthopaedic Reports, Год журнала: 2024, Номер unknown, С. 100472 - 100472
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11657 - 11657
Опубликована: Окт. 30, 2024
Copper is crucial for many physiological processes across mammalian cells, including energy metabolism, neurotransmitter synthesis, and antioxidant defense mechanisms. However, excessive copper levels can lead to cellular toxicity "cuproptosis", a form of programmed cell death characterized by the accumulation within mitochondria. Tumor cells are less sensitive this than normal mechanism which remains unclear. We address important issue exploring role heat shock factor 1 (HSF1), transcription that highly expressed several types cancer has in tumor survival, protecting against copper-mediated cytotoxicity. Using pancreatic ductal adenocarcinoma we show triggers proteotoxic stress response (PSR), activating HSF1 overexpressing diminishes intracellular prevents copper-induced amyloid fibrils formation, highlighting HSF1's preserving proteasomal integrity. treatment decreases lipoylation dihydrolipoamide S-acetyltransferase (DLAT), an enzyme necessary cuproptosis, induces DLAT oligomerization, insoluble suppressed HSF1, addition enhancing interaction between DLAT. Our findings uncover how protects damage thus represents novel therapeutic target death.
Язык: Английский
Процитировано
1
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Ноя. 15, 2024
Cancer is a complex disease characterized by specific “mission-critical” events that drive the uncontrolled growth and spread of tumor cells their offspring. These are essential for advancement disease. One main contributors to these dysregulation cell death pathways—such as apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, parthanatos and—allows cancer avoid programmed continue proliferating unabated. The different pathways in cancers provide useful targets treatment. This review examines recent progresses preclinical clinical development targeting dysregulated To develop effective therapies, it identify target mission-critical prevent from timely death. By precisely crucial events, researchers can therapies with maximum impact minimal side effects. A comprehensive understanding molecular cellular mechanisms underlying regulated will further highly personalized treatments.
Язык: Английский
Процитировано
1