Linking Androgens and Pedophilic Disorder
Опубликована: Янв. 1, 2025
Язык: Английский
What is internet for when studying is exhausting? Cyberaggression profiles associations to school stress management skills and study burnout among Polish and Turkish adolescents
Current Psychology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 18, 2025
Язык: Английский
Molecular mechanisms underlying the erectogenic effects of nutraceutical lunamarine, a novel PDE5 inhibitor derived from watermelon (Citrullus lanatus)
Discover Food,
Год журнала:
2024,
Номер
4(1)
Опубликована: Ноя. 21, 2024
The
research
paper
investigates
the
phytochemicals
of
watermelon
(Citrullus
lanatus)
as
potential
novel
inhibitors
phosphodiesterase
type
5
(PDE5),
which
is
essential
for
treating
erectile
dysfunction
and
pulmonary
arterial
hypertension.
A
total
150
compounds
were
screened
against
five
PDE5
enzyme
structures
using
molecular
docking
techniques
with
Chimera
AutoDock
Vina.
Interactions
visualized
PyMOL,
while
SwissADME
was
employed
to
predict
pharmacokinetic
properties,
ProTox-II
utilized
assess
toxicity.
Lunamarine
has
emerged
a
promising
candidate
inhibition,
demonstrating
superior
pharmacokinetics
favorable
toxicity
profiles.
It
exhibited
high
gastrointestinal
absorption
permeability
across
blood–brain
barrier,
potentially
outperforming
existing
inhibitors.
binding
energies
ranged
from
−
9.421
9.55
kcal/mol
various
targets,
indicating
comparable
efficacy.
Structural
analyses
revealed
significant
hydrophobic
interactions
PHE820
LEU725,
well
hydrogen
bonding
TYR612,
are
crucial
formation
pocket.
Lunamarine's
effect
on
catalytic
zinc
coordination
evidenced
by
receptor-ligand
distances
3.6
3.7
Å.
These
findings
suggest
that
lunamarine
may
provide
advantages
over
current
therapies,
particularly
regarding
its
penetration
central
nervous
system.
study
recommends
further
in
vitro
vivo
validation
lunamarine's
efficacy
safety,
an
exploration
other
conditions
related
PDE5.
This
could
pave
way
development
watermelon-derived
nutraceuticals
disorders
associated
Язык: Английский
The Relationship between Perceived Stress and Sexual Function in Men with the Moderating Role of Marital Intimacy: A Descriptive Study
Journal of Rafsanjan University of Medical Sciences,
Год журнала:
2024,
Номер
23(4), С. 178 - 192
Опубликована: Июль 1, 2024
Язык: Английский
Nasal Treatment of Standardized Centella Asiatica Leaves Extract Ameliorates Chronic Unpredictable Mild Stress in Laboratory Rats
Biomedical & Pharmacology Journal,
Год журнала:
2024,
Номер
17(4), С. 2217 - 2229
Опубликована: Дек. 30, 2024
Objective:
To
assess
the
effectiveness
of
nasal
solution
Centella
asiatica
leaves
standardized
to
triterpenoids
(INDCA-NS)
in
preventing
“chronic
unpredictable
mild
stress”
(CUMS)
rats.
Methods:
The
study
involved
six
groups
twelve
rats
each,
with
five
receiving
CUMS
induction
and
one
group
without
CUMS,
serving
as
a
vehicle
control
(VC).
other
received
intranasal
administration
saline,
buspirone,
or
INDCA-NS
(10,30
100
µg/rat/day,
2.5,
7.5,
10
µg/nostril/twice
daily)
from
day
35
49.
Behavioral
parameters
were
assessed
using
marble
burying
test,
Y-maze,
Morris
water
maze,
sucrose
preference
resident
intruder
test
on
days
0,
35,
42,
49,
respectively.
levels
stress-related
biomarkers,
cortisol
“brain-derived
neurotrophic
factor”
(BDNF)
hypothalamus
measured
ELISA
kits.
data
was
analyzed
analysis
variance
followed
by
pairwise
comparisons,
significance
set
at
P
<
0.05.
Results:
led
significant
increase
anxiety,
anhedonia,
aggression,
stress
markers,
well
reduction
working
spatial
memory
(vs.
VC).
BUS
for
14
resulted
dose-dependent
prevention
CUMS-induced
memory,
but
not
Morris’s
maze
BDNF
levels.
Conclusion:
Subacute
showed
chronic
stress-preventive
potential
rats,
indicated
aggression
probably
through
reduction.
Язык: Английский