Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats DOI
Shoko Saito, Hiroshi Keino, Ichiro Takasaki

и другие.

Ocular Immunology and Inflammation, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Апрель 23, 2025

To investigate alterations in circulating microRNAs (miRNAs) the development of experimental autoimmune uveoretinitis (EAU) rats. Lewis rats were immunized with interphotoreceptor retinoid binding protein (IRBP) peptide (R14) and EAU clinical scores assessed on day 0 (baseline), days 7, 14, 21 after immunization. Total RNA was isolated from serum at same timepoints used for microarray analysis. The score peaked 14 decreased 21. Hierarchical cluster analysis principal component (PCA) miRNA expression displayed distinctly different profiles between baseline Microarray revealed significantly increased 5 (day 7), 9 14), 10 21) miRNAs, 19 20 miRNAs compared to baseline. Of note, miRNA-146a-5p, known be involved EAU, miRNA-150-5p elevated Bioinformatics that mucin type O-glycan biosynthesis cell adhesion molecules major pathways affected during EAU. PCA showed versus IRBP Upregulation miRNA-146a-5p observed effector resolution phases Analysis may help delineate systemic epigenetic changes occurring lead new insights our understanding human uveitis.

Язык: Английский

Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway DOI Creative Commons
Jiajia Liu,

Jinyang Shi,

Shuling Niu

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The therapeutic potential of genistein (GEN) in rheumatoid arthritis (RA), particularly with regard to its role exosome secretion and the inflammatory microenvironment through Rab27/Mfge8/nSMase2 pathway.

Язык: Английский

Процитировано

1
Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats DOI
Shoko Saito, Hiroshi Keino, Ichiro Takasaki

и другие.

Ocular Immunology and Inflammation, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Апрель 23, 2025

To investigate alterations in circulating microRNAs (miRNAs) the development of experimental autoimmune uveoretinitis (EAU) rats. Lewis rats were immunized with interphotoreceptor retinoid binding protein (IRBP) peptide (R14) and EAU clinical scores assessed on day 0 (baseline), days 7, 14, 21 after immunization. Total RNA was isolated from serum at same timepoints used for microarray analysis. The score peaked 14 decreased 21. Hierarchical cluster analysis principal component (PCA) miRNA expression displayed distinctly different profiles between baseline Microarray revealed significantly increased 5 (day 7), 9 14), 10 21) miRNAs, 19 20 miRNAs compared to baseline. Of note, miRNA-146a-5p, known be involved EAU, miRNA-150-5p elevated Bioinformatics that mucin type O-glycan biosynthesis cell adhesion molecules major pathways affected during EAU. PCA showed versus IRBP Upregulation miRNA-146a-5p observed effector resolution phases Analysis may help delineate systemic epigenetic changes occurring lead new insights our understanding human uveitis.

Язык: Английский

Процитировано

0