Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 24, 2024

The liver is the largest, important organ and site for essential biochemical reactions in human body. It has function to detoxify toxic substances synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity mortality worldwide, creating substantial economic burden. Oxidative stress, excessive inflammation, dysregulated energy metabolism significantly contributed diseases. Therefore, discovery novel therapeutic drugs treatment are urgently required. For centuries, flavonoids their preparations which have beneficial health effects chronic been used treat various illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins chalcones. primary objective this review assess efficacy safety flavonoids, from clinical point view considering clinically relevant end-points. We summarized recent progress research hepatoprotective molecular mechanisms different bioactive ingredients also outlined networks underlying signaling pathways. Further pharmacology toxicology will contribute development natural products derivatives as medicines with alluring prospect application.

Язык: Английский

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Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action

Journal of Food Science and Technology, Год журнала: 2024, Номер 61(11), С. 2046 - 2056

Опубликована: Май 18, 2024

Язык: Английский

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Fucoxanthin Induces Ferroptosis in Cancer Cells via Downregulation of the Nrf2/HO−1/GPX4 Pathway

Molecules, Год журнала: 2024, Номер 29(12), С. 2832 - 2832

Опубликована: Июнь 14, 2024

This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used detect inhibitory effects of on SCC-25 human squamous carcinoma cells. levels reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Western blotting assess peroxidase 4 (GPX4), nuclear factor erythroid 2-related 2 (Nrf2), Keap1, solute carrier family 7 member 11 (SLC7A11), transferrin receptor protein 1 (TFR1), p53, heme oxygenase (HO-1) expression. Molecular docking performed validate interactions. Compared with control group, activity fucoxanthin-treated cells significantly decreased in dose- time-dependent manner. MMP, GSH, SOD cells; ROS, MDA, increased. mRNA expression GPX4, Nrf2, HO-1 decreased, whereas TFR1 p53 increased, concentration-dependent analysis revealed that binding free energies SLC7A11, HO-1, below -5 kcal/mol, primarily based active site hydrogen bonding. Our findings suggest can induce cells, highlighting its treatment for

Язык: Английский

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Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

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Ferroptosis in organ fibrosis: Mechanisms and therapeutic approaches

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114341 - 114341

Опубликована: Март 1, 2025

Язык: Английский

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