Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 4, 2025
Cervical
cancer
(CC)
is
a
significant
global
health
issue
and
remains
one
of
the
leading
causes
cancer-related
mortality
in
women.
Radiotherapy
crucial
treatment
modality
for
CC;
however,
tumor
heterogeneity
resistance
to
radiotherapy
often
result
suboptimal
outcomes
some
patients,
including
recurrence
metastasis.
Periostin
(POSTN),
matricellular
protein
within
microenvironment,
has
been
implicated
promotion
progression
resistance,
particularly
through
mechanisms
such
as
epithelial-mesenchymal
transition
(EMT).
Despite
this,
role
POSTN
CC
patients
underexplored.
Therefore,
this
study,
we
investigated
prognostic
significance
expression
undergoing
radical
explored
potential
underlying
resistance.
We
analyzed
data
from
92
The
Cancer
Genome
Atlas
(TCGA)
153
our
institution,
assessing
levels
mRNA
analysis
immunohistochemistry
(IHC).
Our
findings
revealed
that
high
was
significantly
associated
with
advanced
stages,
poorer
outcomes,
worse
overall
survival
(OS).
Additionally,
multivariate
Cox
regression
identified
an
independent
factor
radiotherapy.
A
nomogram
integrating
clinicopathological
features
demonstrated
superior
predictive
accuracy
OS.
Drug
sensitivity
suggested
may
be
linked
multiple
chemotherapeutic
agents.
Furthermore,
weighted
correlation
network
(WGCNA)
gene
set
enrichment
(GSEA)
EMT
top
enriched
pathway
expression,
suggesting
it
play
critical
Subsequently,
vitro
experiments
confirmed
knockdown
inhibited
HeLa
cell
proliferation,
invasion,
enhanced
radiosensitivity,
while
promoting
apoptosis.
These
indicate
risk
poor
prognosis
radiotherapy,
targeting
improve
efficacy
by
reducing
proliferation
Язык: Английский
Construction of a novel five programmed cell death-related gene signature as a promising prognostic model for triple negative breast cancer
PeerJ,
Год журнала:
2025,
Номер
13, С. e19359 - e19359
Опубликована: Апрель 28, 2025
Triple
negative
breast
cancer
(TNBC)
is
a
more
aggressive
subtype
of
that
usually
progresses
rapidly,
develops
drug
resistance,
metastasis,
and
relapses,
remains
challenge
for
clinicians
to
treat.
Programmed
cell
death
(PCD),
conserved
mechanism
suicide
controlled
by
various
pathways,
contributed
carcinogenesis
progression.
Nevertheless,
the
prognostic
significance
PCD-related
genes
in
TNBC
largely
unclear,
accurate
models
are
urgently
needed.
Gene
expression
profiles
clinical
information
patients
were
obtained
from
The
Cancer
Genome
Atlas
(TCGA)
Expression
Omnibus
(GEO)
database.
Least
absolute
shrinkage
selection
operator
(LASSO)
multivariate
Cox
regression
analysis
used
establish
gene
signature.
Kaplan-Meier
plotter,
receiver
operating
characteristic
curves,
nomogram
applied
validate
value
set
enrichment
was
carried
out
investigate
pathways
molecular
functions.
Five
including
SEPTIN3,
SCARB1,
CHML,
SYNM,
COL5A3
identified
risk
score
patients.
Patients
stratified
into
high-risk
or
low-risk
group
showed
significantly
different
survival
outcome,
immune
infiltration,
susceptibility.
curves
good
performance
prediction
cohorts.
revealed
five-gene
signature
associated
with
tumor
metabolism,
proliferation,
invasion
microenvironment.
Nomogram
established.
A
novel
five
could
be
TNBC.
present
work
might
offer
useful
insights
digging
sensitive
effective
biomarkers
prognosis
establishing
model
management.
Язык: Английский