The Effect of Ketoconazole and Quinestrol Combination on Reproductive Physiology in Male Mice DOI Creative Commons
Yu Ji,

Yujie Wang,

Yuhang Liu

и другие.

Animals, Год журнала: 2024, Номер 14(22), С. 3240 - 3240

Опубликована: Ноя. 12, 2024

This study investigates whether ketoconazole, a CYP3A4 inhibitor, can enhance the suppressive effects of quinestrol on reproductive capacity, potentially allowing for reduced dosage while maintaining its efficacy. A total 104 healthy adult male mice were divided into two groups, assessed at 10 and 30 days. Within each group, six treatment categories tested: control (CK), alone (Q1, Q5), combined with varying doses ketoconazole (Q1 + K0.4, Q1 K2, Q5 K0.4). The key parameters measured included internal organ weights, sperm density, motility, abnormalities, enzyme content in intestinal liver tissues. After days, combination low dose K0.4) showed most significant pronounced reducing potential, notable reductions epididymal weight, abnormality rate vitality, serum hormone levels, small intestine liver. Although some returned to near-baseline levels after K0.4 regimen continued exhibit seminal vesicle weight testosterone levels. Importantly, did not significantly increase content, indicating effective metabolic inhibition. especially regimen, demonstrated noticeable impact capacity. strong inhibition, suggesting that substantially enhances efficacy fertility control.

Язык: Английский

Mn-MOF based electrochemical sensor for highly detection of poisonous rat bait (Bromadiolone) DOI
Ayman S. Eliwa,

Perihan A. Khalaf-Alla,

Mostafa A. Besher

и другие.

Inorganic Chemistry Communications, Год журнала: 2024, Номер 171, С. 113554 - 113554

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

3

Barn Owls as a Nature-Based Solution for Pest Control: A Multinational Initiative Around the Mediterranean and Other Regions DOI Creative Commons
Vasileios Bontzorlos, Shlomo Cain,

Yossi Leshem

и другие.

Conservation, Год журнала: 2024, Номер 4(4), С. 627 - 656

Опубликована: Ноя. 4, 2024

Pest rodents cause extensive damage to crops worldwide. Up 40% of global crop production is lost annually pests and diseases, with accounting for 15–30% this loss amounting billions dollars each year. The current method controlling rodent populations involves the use chemical rodenticides. While effective in short term, these chemicals pose serious environmental health risks, leading secondary poisoning non-target species other long-term negative ecological consequences, underscoring need adopt more sustainable pest-control measures. Nature-Based Solutions (NbSs), on hand, are increasingly recognized addressing challenges such as climate change, biodiversity loss, development, they include actions that protect, sustainably manage, restore ecosystems. In context, Barn Owls (Tyto alba) highly a natural pest-rodent control agents agro-ecosystems. has wide distribution adaptability various environments, its diet consists predominantly small mammals, making up from 50–60% even 90–95% according different geographical regions. Each Owl family can consume thousands annually, creating high potential reduce infestations. Deploying nest boxes agricultural areas significantly increase populations, ensuring continuous control. Limitations solution must also be taken into consideration predation mammals not pests, possible competition nocturnal birds prey. Ιn paper, we aim introduce concept owls NbS pest outline main challenges, pitfalls, advantages, disadvantages implementing new region, all necessary in-between steps (scientific, societal, administrative, educational) have followed successful implementation. So far, several countries successfully implemented box schemes, Israel Cyprus achieving reduction pesticides by 45% 58%, respectively, whereas project spreading Mediterranean (Jordan, Palestine Authority, Greece, Morocco, Spain), palm plantations Malaysia USA, vineyards Napa Valley California. success programs relies integrating scientific research, societal needs, supportive policy frameworks, education. both bottom-up top-down initiatives, participation farmers local communities establish deploy solution. Continuous research explore systematically owl trophic ecology, foraging breeding interactions landscape, land uses temporal spatial scales, habitat suitability, availability nesting sites, regional conditions addressed.

Язык: Английский

Процитировано

1

The Effect of Ketoconazole and Quinestrol Combination on Reproductive Physiology in Male Mice DOI Creative Commons
Yu Ji,

Yujie Wang,

Yuhang Liu

и другие.

Animals, Год журнала: 2024, Номер 14(22), С. 3240 - 3240

Опубликована: Ноя. 12, 2024

This study investigates whether ketoconazole, a CYP3A4 inhibitor, can enhance the suppressive effects of quinestrol on reproductive capacity, potentially allowing for reduced dosage while maintaining its efficacy. A total 104 healthy adult male mice were divided into two groups, assessed at 10 and 30 days. Within each group, six treatment categories tested: control (CK), alone (Q1, Q5), combined with varying doses ketoconazole (Q1 + K0.4, Q1 K2, Q5 K0.4). The key parameters measured included internal organ weights, sperm density, motility, abnormalities, enzyme content in intestinal liver tissues. After days, combination low dose K0.4) showed most significant pronounced reducing potential, notable reductions epididymal weight, abnormality rate vitality, serum hormone levels, small intestine liver. Although some returned to near-baseline levels after K0.4 regimen continued exhibit seminal vesicle weight testosterone levels. Importantly, did not significantly increase content, indicating effective metabolic inhibition. especially regimen, demonstrated noticeable impact capacity. strong inhibition, suggesting that substantially enhances efficacy fertility control.

Язык: Английский

Процитировано

0