Viruses,
Год журнала:
2024,
Номер
16(10), С. 1612 - 1612
Опубликована: Окт. 15, 2024
Monocytes
and
macrophages
are
part
of
innate
immunity
constitute
the
first
line
defense
against
pathogens.
Bone
marrow-derived
monocytes
circulate
in
bloodstream
for
one
to
three
days
then
typically
migrate
into
tissues,
where
they
differentiate
macrophages.
Circulatory
represent
5%
nucleated
cells
normal
adult
blood.
Following
differentiation,
distributed
various
tissues
organs
take
residence
maintain
body
homeostasis.
Emerging
evidence
has
highlighted
critical
role
monocytes/macrophages
oncogenic
viral
infections,
mainly
their
crucial
functions
persistence
disease
progression.
These
findings
open
opportunities
target
context
viruses
explore
potential
as
immunotherapies.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2770 - 2770
Опубликована: Март 19, 2025
Insulin
resistance
(IR)
is
a
significant
factor
in
the
development
and
progression
of
metabolic-related
diseases
like
dyslipidemia,
T2DM,
hypertension,
nonalcoholic
fatty
liver
disease,
cardiovascular
cerebrovascular
disorders,
cancer.
The
pathogenesis
IR
depends
on
multiple
factors,
including
age,
genetic
predisposition,
obesity,
oxidative
stress,
among
others.
Abnormalities
insulin-signaling
cascade
lead
to
host,
insulin
receptor
abnormalities,
internal
environment
disturbances,
metabolic
alterations
muscle,
liver,
cellular
organelles.
complex
multifaceted
characteristics
signaling
envisage
their
thorough
comprehensive
understanding
at
molecular
level.
Therapeutic
strategies
for
include
exercise,
dietary
interventions,
pharmacotherapy.
However,
there
are
still
gaps
be
addressed,
more
precise
biomarkers
associated
chronic
lifestyle
interventions
needed.
Understanding
these
pathways
essential
developing
effective
treatments
IR,
reducing
healthcare
costs,
improving
quality
patient
life.
Biomedical Journal,
Год журнала:
2025,
Номер
unknown, С. 100867 - 100867
Опубликована: Апрель 1, 2025
Cardiac
macrophages
(CMs)
are
the
most
abundant
immune
cell
type
in
heart.
They
critical
for
maintaining
cardiac
homeostasis
and
orchestration
of
responses
to
ischemic
non-ischemic
cardiomyopathies.
Their
functions
highly
heterogeneous
regulated
by
their
tissue
microenvironment.
CMs
have
high
plasticity,
which
allows
them
perform
various
myocardium
bring
about
within
cardiovascular
system
(CVS).
also
play
roles
coronary
development
angiogenesis,
repair
remodeling,
conduction
clearance
necrotic
apoptotic
cells.
However,
there
is
a
paucity
studies
on
biology
both
steady
state
disease,
especially,
humans.
In
this
review,
we
discuss
multifaceted
heart,
focusing
ontogeny,
homeostatic
immunological
during
inflammation
reparative
processes
post-injury.
We
highlight
heterogeneity
phenotypes
as
well
pathogenesis
pathological
conditions
such
myocarditis,
myocardial
fibrosis
heart
failure.
Understanding
unique
characteristics
milieu
macrophage-specific
therapeutic
interventions
alleviate
global
burden
disease
(CVD).
Therefore,
future
should
focus
further
improving
understanding
harness
potential
targets
disorders.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 21, 2025
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
fatal
interstitial
lung
disease
characterized
by
progressive
scarring,
alveolar
destruction,
and
limited
therapeutic
options.
Although
the
exact
etiology
of
IPF
remains
unclear,
emerging
evidence
suggests
that
ferroptosis,
an
iron-dependent
form
regulated
cell
death
driven
lipid
peroxidation
oxidative
stress,
plays
significant
role
in
its
pathogenesis.
Ferroptotic
stress
not
only
compromises
epithelial
integrity,
but
also
triggers
inflammatory
responses
profibrotic
signaling
cascades
activate
sustain
fibroblast
dysfunction.
This
review
delineates
core
regulatory
pathways
iron
metabolism,
peroxidation,
antioxidant
defenses,
mitochondrial
remodeling,
RNA
editing,
with
emphasis
on
their
relevance
IPF.
We
explore
how
injury
macrophage-derived
signals
initiate
subsets,
shaped
scRNA-seq-defined
heterogeneity
plasticity,
respond
to
these
cues
reinforcing
ECM
deposition
stress.
Therapeutic
avenues
targeting
including
supplementation,
chelation,
modulation
are
discussed
alongside
cell-specific
interventions
nanodelivery
strategies.
By
integrating
recent
advances
molecular
profiling
ferroptosis
biology,
this
provides
framework
for
leveraging
as
tractable
target
identifies
novel
directions
precision
antifibrotic
therapy.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 9, 2024
Hesperidin
(Hes)
protects
different
organs
from
damage
by
acting
as
a
potent
antioxidant
and
anti-inflammatory.
This
study
aims
to
evaluate
the
gastroprotective
effects
of
free
hesperidin
its
chitosan
nanoparticles
(HNPs)
against
ethanol-induced
gastric
ulcers
in
rats,
hypothesizing
that
HNPs
will
enhance
bioavailability
therapeutic
efficacy
due
improved
solubility
targeted
delivery.
were
synthesized
via
ion
gelation
characterized
using
TEM,
SEM,
zeta
potential
analyses.
Key
assessments
included
acidity,
histological
analysis,
markers
inflammation,
oxidative
stress,
apoptosis.
significantly
decreased
reduced
inflammatory
apoptotic
markers,
enhanced
enzyme
activities
compared
esomeprazole.
Furthermore,
Sirt-1,
PGC-1α,
HO-1,
FOXO1
gene
expression
also
evaluated.
raised
downregulated
FOXO1,
they
suppressed
NF-κB
p65,
COX-2,
IL-1β,
CD86,
P53,
caspase-3
increased
Sirt-1
activity.
treatment
notably
restored
activity,
stress
outcomes
more
effectively
than
These
results
indicate
ulcers,
potentially
offering
effective
strategy.
Further
research
should
explore
clinical
applications
human
subjects.
Атеросклероз и дислипидемии,
Год журнала:
2024,
Номер
3(56), С. 65 - 72
Опубликована: Сен. 1, 2024
Цель.
Нарушение
воспалительного
ответа
моноцитов/макрофагов
является
важным
механизмом
в
патогенезе
атеросклероза,
лежащего
основе
ИБС.
Целью
настоящего
исследования
явилось
изучение
секреции
воспалительных
цитокинов
культивируемыми
моноцитами/макрофагами
пациентов
с
ранним
развитием
Материалы
и
методы.
В
исследование
включено
73
пациента,
том
числе,
38
больных
рано
возникшей
ИБС
35
без
ИБС,
сопоставимых
по
полу
возрасту.
Первичную
культуру
CD14+
моноцитов
получали
методом
иммуномагнитной
сепарации.
Для
стимуляции
добавляли
клеток
липополисахарид
(ЛПС)
на
24
ч
1
6
сутки.
Базальную
ЛПС-стимулированную
секрецию
ФНО-α,
ИЛ-1β,
ИЛ-6,
ИЛ-8
MCP-1
оценивали
иммуноферментного
анализа
2
7
сутки
культивирования.
определения
показателей,
независимо
связанных
наличием
оценки
выраженности
такой
связи,
был
выполнен
логистический
регрессионный
анализ.
Результаты.
Уровень
базальной
МСР-1
выше
у
сравнению
пациентами
контрольной
группы.
Уровни
повторно
стимулированной
ФНО-α
уровни
ЛПС-стимулированной
ИЛ-1β
вторые
шестые
так
же
были
ИЛ-6
не
имели
различий
Ни
базальная,
ни
стимулированная
секреция
отличалась
обеих
групп.
ЛПС-стимулированная
Повторно
была
Результаты
логистического
регрессионного
показали,
что
являются
независимыми
предикторами
наличия
наряду
курением,
индексом
массы
тела
уровнем
холестерина
ЛВП
сыворотке
крови.
Заключение.
свидетельствуют
о
провоспалительной
активации
проявлялось
повышении
индуцированной
провоспалительных
меньшей
степени
ИЛ-6.
Biophysics Reports,
Год журнала:
2024,
Номер
11(1), С. 12 - 12
Опубликована: Сен. 13, 2024
The
purpose
of
this
study
was
to
examine
the
secretion
inflammatory
cytokines
by
cultured
monocytes/macrophages
in
patients
with
premature
coronary
artery
disease
(CAD).
included
38
CAD
and
35
without
CAD.
A
primary
culture
CD14+
monocytes
obtained
immunomagnetic
separation.
response
induced
incubation
a
cell
lipopolysaccharide
(LPS)
for
24
hours
on
Days
1
6.
Basal
LPS-stimulated
cytokines,
tumor
necrosis
factor-α
(TNF-α),
interleukin-1β
(IL-1β),
interleukin-6
(IL-6),
interleukin-8
(IL-8)
monocyte
chemotactic
protein-1
(MCP-1)
assessed
enzyme
immunoassay
2
7
cultivation.
level
basal
TNF-α,
IL-1β,
IL-6,
MCP-1
higher
compared
control
group.
levels
re-stimulated
TNF-α
IL-1β
second
sixth
days
were
also
day
did
not
differ
both
groups,
but
results
logistic
regression
analysis
showed
that
IL-6
independently
associated
CAD,
along
smoking,
body
mass
index
serum
HDL-cholesterol
levels.
