The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats
Journal of Agriculture and Food Research,
Год журнала:
2025,
Номер
unknown, С. 101891 - 101891
Опубликована: Апрель 1, 2025
Язык: Английский
Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats
International Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Окт. 11, 2024
Empagliflozin,
a
sodium-glucose
co-transporter
2
(SGLT2)
inhibitor,
has
recently
reported
to
prevent
the
depression
in
chronic
animal
model.
The
present
study
aimed
explore
antidepressant
potential
of
empagliflozin
using
neuroinflammation-mediated
involving
olfactory
bulbectomy
(OBX)
model
diabetic
rats.
A
low
dose
streptozotocin
was
injected
induce
diabetes
all
group
animals.
Following
confirmation
hyperglycemia,
OBX
surgery
performed.
Post-surgery,
drug
treatments
were
administered
orally
for
14
consecutive
days.
evaluated
effects
daily
oral
administration
at
doses
5
and
10
mg/kg,
alongside
metformin
(200
mg/kg)
clomipramine
(50
mg/kg),
on
OBX-induced
behavioral
Separate
sham
vehicle
control
groups
also
maintained.
Behavioral
parameters
open
field,
forced
swim
test,
elevated
plus
maze
splash
test
recorded
28
Язык: Английский
Assessment of In Vitro Antioxidant and Anti-Inflammatory Activities of Pumpkin (Cucurbita pepo) Natural Plant
Natural Product Communications,
Год журнала:
2024,
Номер
19(5)
Опубликована: Май 1, 2024
Objectives
The
objective
of
this
research
was
to
investigate
the
potential
anti-inflammatory
properties
Cucurbita
pepo
fruit.
Given
adverse
effects
associated
with
long-term
use
or
excessive
doses
conventional
medications,
exploring
herbal
therapies
as
alternatives
has
become
increasingly
important.
Methods
Various
preliminary
tests
and
antioxidant
assays,
both
enzymatic
non-enzymatic,
were
conducted
on
C
.
Bioactive
substances
present
in
fruit,
including
alkaloids,
carbohydrates,
flavonoids,
tannins,
amino
acids,
triterpenoids,
saponin
glycosides,
identified
through
early
analysis.
Different
extraction
solvents,
such
chloroform,
methanol,
water,
utilized
extract
samples.
methanolic
subjected
further
testing
for
its
vitro
characteristics.
This
involved
evaluating
their
ability
stabilize
RBC
membranes,
inhibit
protein
denaturation,
suppress
proteinase
activity
using
two
concentrations
(150
µg/ml
300
µg/ml)
extract.
Results
C.
fruit
exhibited
strong
free
radical
scavenging
DPPH
H
2
O
assays.
Moreover,
it
demonstrated
dose-dependent
stabilization
resulting
reduced
hemolysis,
activity.
These
findings
suggest
potent
Conclusion
study
found
that
significantly
inflammation.
demonstrates
promise
natural
chemicals
less
risky
substitutes
traditional
medications.
Potentially
safe
efficient
treatments
inflammatory
illnesses
could
be
remedies
Therefore,
highlights
significance
a
treatment
option
inflammation-related
diseases.
Язык: Английский
Exploring the Protective Mechanisms of Chayote (Sechium edule) Juice in Mitigating Streptozotocin‐Induced Pancreatic Dysfunction
eFood,
Год журнала:
2024,
Номер
6(1)
Опубликована: Дек. 29, 2024
ABSTRACT
Chayote
(
Sechium
edule
)
has
been
traditionally
used
in
Mexico
to
manage
diabetes,
owing
its
hypoglycemic,
anti‐oxidant,
and
anti‐inflammatory
properties.
However,
the
specific
effects
mechanisms
of
chayote
juice
(SEJ)
preventing
pancreatic
dysfunction
remain
underexplored.
This
study
investigated
protective
underlying
SEJ
multiple
low‐dose
streptozotocin
(MLD‐STZ)‐induced
diabetic
mouse
model
H
2
O
‐treated
insulinoma
cell
line
(MIN‐6).
C57BL/6
mice
were
administered
MLD‐STZ
induce
treated
with
SEJ.
Diabetic
parameters,
islet
morphology,
protein
expressions
evaluated.
MIN‐6
cells
assess
SEJ's
at
cellular
level.
Molecular
docking
studies
performed
elucidate
interactions
between
phenolic
compounds
key
proteins
involved
oxidative
stress.
significantly
preserved
structure
insulin
levels,
reducing
blood
glucose
levels.
Mechanistically,
suppressed
expression
apoptosis
markers
(caspase‐3,
PARP,
BAX)
inflammatory
(NF‐κB,
iNOS,
NLRP3)
pancreas
MIN6
cells,
indicating
protection
β‐cells.
Furthermore,
upregulates
endogenous
anti‐oxidant
(Nrf‐2,
HO‐1),
which
are
essential
for
mitigating
stress‐induced
stress
diabetes
circumstances.
indicated
that
vicenin‐2
exhibit
strong
binding
affinities
KEAP‐1,
Nrf‐2,
HO‐1
proteins.
demonstrates
substantial
through
anti‐apoptotic,
actions.
These
findings
suggest
could
be
developed
as
a
functional
food
management.
Язык: Английский