HPLC-ESI-QTOF-MS Profiling of Antibacterial Bioactive Solvent Fractions of Senna alata (L.) Roxb (Fabaceae) Leaves, and in Silico Prediction of Pharmacokinetic, Drug-likeness, and Toxicity of Major Phyto-components
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119492 - 119492
Опубликована: Фев. 1, 2025
Язык: Английский
Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(24), С. 21633 - 21640
Опубликована: Дек. 9, 2024
Язык: Английский
Therapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria
Udensi Justina Ugochi,
Anyanwu Charles Obinna,
Emedoh Andrew Emeka
и другие.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 2, 2025
Язык: Английский
Artificial Intelligence, Computational Tools and Robotics for Drug Discovery, Development, and Delivery
Intelligent Pharmacy,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Development of flavonoid-loaded chitosan composite from Kalanchoe pinnata for antibacterial applications
Discover Chemistry.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Март 28, 2025
Язык: Английский
Antibacterial Activity of Traditional Medicinal Plants: Combating Antibiotics Resistance in Animal Wound Infections
Veterinary Medicine and Science,
Год журнала:
2025,
Номер
11(3)
Опубликована: Май 1, 2025
ABSTRACT
The
rise
of
antibiotic
resistance
poses
a
significant
challenge
to
veterinary
medicine,
particularly
in
the
treatment
wound
infections
animals.
This
study
aimed
evaluate
antibacterial
properties
traditional
medicinal
plants
against
four
bacterial
strains
isolated
from
septic
animal
and
compare
their
effectiveness
with
broad‐spectrum
antibiotics.
A
total
150
isolates
were
collected
using
sterile
cotton
swabs,
cultured
on
nutrient
mannitol
salt
agar
for
growth
identified
through
catalase
coagulase
tests.
assessed
tested
isolates’
susceptibility
disc
diffusion
method.
Among
isolates,
Staphylococcus
aureus
was
most
common
pathogen,
accounting
26.6%
(40
isolates),
followed
by
Escherichia
coli
at
26%
(39
isolates).
Streptococcus
spp.
Pseudomonas
found
20%
(30
isolates)
16%
(25
respectively.
Antibiogram
analysis
revealed
notable
resistance,
S.
showing
highest
Ciprofloxacin
(60.5%)
Rifampicin
(57.5%).
E.
exhibited
61.5%
56.4%
streptomycin.
had
(53.3%),
whereas
showed
greatest
Chloramphenicol
(52%).
Ethanol
extracts
plants,
prepared
various
solvents,
utilized
testing.
Loranthus
acaciae
Cymbopogon
proximus
concentrations
60–90
µL
demonstrated
largest
inhibition
zones,
ranging
55.5
±
3.85
57.5
2.5
mm
.
Inhibition
zones
ranged
50
2
48.3
1.7
mm.
In
comparison,
standard
antibiotics
58.95
2.55–60
,
slightly
lower
(51.65
1.6–49
1
mm)
observed
These
findings
underscore
activity
multidrug‐resistant
pathogens
infections,
highlighting
potential
accelerate
healing,
reduce
infection
severity
provide
cost‐effective
alternative
combat
resistance.
Язык: Английский
Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Abstract
Chemotherapy
(CT)
is
one
of
the
flagship
options
for
treatment
cancers
worldwide.
It
involves
use
cytotoxic
anticancer
agents
to
kill
or
inhibit
proliferation
cancer
cells.
However,
despite
its
clinical
efficacy,
CT
triggers
side
effect
toxicities
in
several
organs,
which
may
impact
patient’s
quality
life
and
outcomes.
While
toxicity
consistent
with
non-ferroptotic
mechanisms
involving
oxidative
stress,
inflammation,
mitochondrial
impairment
other
aberrant
signalling
leading
apoptosis
necroptosis,
recent
studies
show
that
ferroptosis,
a
non-apoptotic,
iron-dependent
cell
death
pathway,
also
involved
pathophysiology
organ
toxicity.
provokes
ferroptosis
via
system
Xc
–
/GPX-4/GSH/SLC7A11
axis
depletion,
ferritinophagy,
iron
overload,
lipid
peroxidation
upregulation
ferritin-related
proteins.
Cisplatin
(CP)
doxorubicin
(DOX)
are
common
drugs
indicated
induce
vitro
vivo.
Studies
have
explored
natural
preventive
therapeutic
strategies
using
ginger
rhizome
major
bioactive
compounds,
6-gingerol
(6G)
zingerone
(ZG),
combat
Ginger
extract,
6G
ZG
mitigate
dysfunction
toxicity,
but
their
effects
on
CT-induced
remain
unclear.
Systematic
investigations
are,
therefore,
needed
unfold
roles
ginger,
as
they
potential
prevention
This
review
reveals
ferroptotic
protective
against
CT-induced,
toxicities.
Язык: Английский
Green Medicine: Advancing Antimicrobial Solutions with Diverse Terrestrial and Marine Plant-Derived Compounds
Processes,
Год журнала:
2024,
Номер
12(11), С. 2316 - 2316
Опубликована: Окт. 22, 2024
Infectious
diseases
continue
to
cause
global
morbidity
and
mortality.
The
rise
of
drug-resistant
pathogens
is
a
major
challenge
modern
medicine.
Plant-based
antimicrobials
may
solve
this
issue;
hence,
review
discussed
in
detail
plant-sourced
antimicrobial
drugs
as
an
alternative
toward
bacterial,
fungal,
viral
pathogens.
Plant-derived
chemicals
from
various
sources
such
marine,
medicinal,
non-medicinal
have
diverse
properties.
Complex
chemical
profiles
these
allow
molecules
interact
with
several
targets
the
microbial
Due
their
multi-component
composition,
compounds
are
more
effective
less
likely
acquire
resistance
than
single-target
antibiotics.
Medicinal
herbs
long
been
used
for
properties;
however,
plants
also
identified
Other
interesting
new
pathways
identification
include
marine
plants,
which
contain
wide
variety
metabolites
that
both
distinct
varied.
We
conducted
thorough
literature
search
non-medicinal,
plant-derived
roles
databases
Scopus,
PubMed,
Google
Scholar,
Web
Science.
synergistic
potential
combining
traditional
attenuate
pathogenesis.
Based
on
existing
research
advancements,
article
emphasizes
importance
continuing
into
plant-based
many
integrating
them
therapies
combat
rising
threat
infections.
Язык: Английский
A Screen of Traditional Chinese Medicinal Plant Extracts Reveals 17 Species with Antimicrobial Properties
Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1220 - 1220
Опубликована: Дек. 17, 2024
Background/Objectives:
Antimicrobial
resistance
(AMR)
is
a
growing
threat
that
undermines
the
effectiveness
of
global
healthcare.
The
Centers
for
Disease
Control
and
Prevention
World
Health
Organization
have
identified
numerous
microbial
organisms,
particularly
members
ESKAPEE
pathogens,
as
critical
threats
to
health
economic
security.
Many
clinical
isolates
these
pathogens
become
completely
resistant
current
antibiotics,
making
treatment
nearly
impossible.
Herbal
remedies,
such
those
found
in
Traditional
Chinese
Medicine
(TCM),
been
practiced
thousands
years
successfully
used
treat
wide
range
ailments,
including
infectious
diseases.
Surprisingly,
despite
this
extensive
knowledge
folk
medicine,
no
plant-derived
antibacterial
drugs
are
currently
approved
use.
As
such,
objective
study
evaluate
antimicrobial
properties
extracts
derived
from
TCM
plants.
Methods:
This
explores
comprehensive
library
comprising
664
132
distinct
plant
species
against
gram-negative
(Escherichia
coli)
gram-positive
(Micrococcus
luteus)
bacteria
using
liquid
solid
vitro
assays.
Results:
Intriguingly,
our
results
reveal
17
with
potent
effective
primarily
Streptococcus
aureus
epidermidis.
A
literature
search
revealed
100
purified
compounds
plants
were
previously
isolated
confirmed
their
properties,
collectively
inhibiting
45
different
bacterial
species.
Conclusions:
Our
indicate
phytobiotics
could
serve
potential
candidates
novel
antimicrobials.
Язык: Английский