A Screen of Traditional Chinese Medicinal Plant Extracts Reveals 17 Species with Antimicrobial Properties DOI Creative Commons
Garrett L. Ellward,

Macie E. Binda,

Dominika I. Dzurny

и другие.

Antibiotics, Год журнала: 2024, Номер 13(12), С. 1220 - 1220

Опубликована: Дек. 17, 2024

Background/Objectives: Antimicrobial resistance (AMR) is a growing threat that undermines the effectiveness of global healthcare. The Centers for Disease Control and Prevention World Health Organization have identified numerous microbial organisms, particularly members ESKAPEE pathogens, as critical threats to health economic security. Many clinical isolates these pathogens become completely resistant current antibiotics, making treatment nearly impossible. Herbal remedies, such those found in Traditional Chinese Medicine (TCM), been practiced thousands years successfully used treat wide range ailments, including infectious diseases. Surprisingly, despite this extensive knowledge folk medicine, no plant-derived antibacterial drugs are currently approved use. As such, objective study evaluate antimicrobial properties extracts derived from TCM plants. Methods: This explores comprehensive library comprising 664 132 distinct plant species against gram-negative (Escherichia coli) gram-positive (Micrococcus luteus) bacteria using liquid solid vitro assays. Results: Intriguingly, our results reveal 17 with potent effective primarily Streptococcus aureus epidermidis. A literature search revealed 100 purified compounds plants were previously isolated confirmed their properties, collectively inhibiting 45 different bacterial species. Conclusions: Our indicate phytobiotics could serve potential candidates novel antimicrobials.

Язык: Английский

HPLC-ESI-QTOF-MS Profiling of Antibacterial Bioactive Solvent Fractions of Senna alata (L.) Roxb (Fabaceae) Leaves, and in Silico Prediction of Pharmacokinetic, Drug-likeness, and Toxicity of Major Phyto-components DOI
Armel Jackson Seukep, Hélène Gueaba Mbuntcha,

Valaire Yemene Matieta

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119492 - 119492

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease DOI
Tomayo Berida, Craig W. Lindsley

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(24), С. 21633 - 21640

Опубликована: Дек. 9, 2024

Язык: Английский

Процитировано

3
Therapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria DOI Creative Commons

Udensi Justina Ugochi,

Anyanwu Charles Obinna,

Emedoh Andrew Emeka

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

0
Artificial Intelligence, Computational Tools and Robotics for Drug Discovery, Development, and Delivery DOI Creative Commons
Ayodele James Oyejide, Yemi A. Adekunle, Oluwatosin David Abodunrin

и другие.

Intelligent Pharmacy, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Development of flavonoid-loaded chitosan composite from Kalanchoe pinnata for antibacterial applications DOI Creative Commons
Md Mobarok Karim, Tahera Lasker, Md Ali Zaber Sahin

и другие.

Discover Chemistry., Год журнала: 2025, Номер 2(1)

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
Antibacterial Activity of Traditional Medicinal Plants: Combating Antibiotics Resistance in Animal Wound Infections DOI Creative Commons

Dan Jia,

Safia Arbab, Hanif Ullah

и другие.

Veterinary Medicine and Science, Год журнала: 2025, Номер 11(3)

Опубликована: Май 1, 2025

ABSTRACT The rise of antibiotic resistance poses a significant challenge to veterinary medicine, particularly in the treatment wound infections animals. This study aimed evaluate antibacterial properties traditional medicinal plants against four bacterial strains isolated from septic animal and compare their effectiveness with broad‐spectrum antibiotics. A total 150 isolates were collected using sterile cotton swabs, cultured on nutrient mannitol salt agar for growth identified through catalase coagulase tests. assessed tested isolates’ susceptibility disc diffusion method. Among isolates, Staphylococcus aureus was most common pathogen, accounting 26.6% (40 isolates), followed by Escherichia coli at 26% (39 isolates). Streptococcus spp. Pseudomonas found 20% (30 isolates) 16% (25 respectively. Antibiogram analysis revealed notable resistance, S. showing highest Ciprofloxacin (60.5%) Rifampicin (57.5%). E. exhibited 61.5% 56.4% streptomycin. had (53.3%), whereas showed greatest Chloramphenicol (52%). Ethanol extracts plants, prepared various solvents, utilized testing. Loranthus acaciae Cymbopogon proximus concentrations 60–90 µL demonstrated largest inhibition zones, ranging 55.5 ± 3.85 57.5 2.5 mm . Inhibition zones ranged 50 2 48.3 1.7 mm. In comparison, standard antibiotics 58.95 2.55–60 , slightly lower (51.65 1.6–49 1 mm) observed These findings underscore activity multidrug‐resistant pathogens infections, highlighting potential accelerate healing, reduce infection severity provide cost‐effective alternative combat resistance.

Язык: Английский

Процитировано

0
Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies DOI Creative Commons
Ademola C. Famurewa, Roland Eghoghosoa Akhigbe,

Mina Y. George

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Язык: Английский

Процитировано

1
Green Medicine: Advancing Antimicrobial Solutions with Diverse Terrestrial and Marine Plant-Derived Compounds DOI Open Access
Du‐Min Jo, Nazia Tabassum,

Do Kyung Oh

и другие.

Processes, Год журнала: 2024, Номер 12(11), С. 2316 - 2316

Опубликована: Окт. 22, 2024

Infectious diseases continue to cause global morbidity and mortality. The rise of drug-resistant pathogens is a major challenge modern medicine. Plant-based antimicrobials may solve this issue; hence, review discussed in detail plant-sourced antimicrobial drugs as an alternative toward bacterial, fungal, viral pathogens. Plant-derived chemicals from various sources such marine, medicinal, non-medicinal have diverse properties. Complex chemical profiles these allow molecules interact with several targets the microbial Due their multi-component composition, compounds are more effective less likely acquire resistance than single-target antibiotics. Medicinal herbs long been used for properties; however, plants also identified Other interesting new pathways identification include marine plants, which contain wide variety metabolites that both distinct varied. We conducted thorough literature search non-medicinal, plant-derived roles databases Scopus, PubMed, Google Scholar, Web Science. synergistic potential combining traditional attenuate pathogenesis. Based on existing research advancements, article emphasizes importance continuing into plant-based many integrating them therapies combat rising threat infections.

Язык: Английский

Процитировано

0
A Screen of Traditional Chinese Medicinal Plant Extracts Reveals 17 Species with Antimicrobial Properties DOI Creative Commons
Garrett L. Ellward,

Macie E. Binda,

Dominika I. Dzurny

и другие.

Antibiotics, Год журнала: 2024, Номер 13(12), С. 1220 - 1220

Опубликована: Дек. 17, 2024

Background/Objectives: Antimicrobial resistance (AMR) is a growing threat that undermines the effectiveness of global healthcare. The Centers for Disease Control and Prevention World Health Organization have identified numerous microbial organisms, particularly members ESKAPEE pathogens, as critical threats to health economic security. Many clinical isolates these pathogens become completely resistant current antibiotics, making treatment nearly impossible. Herbal remedies, such those found in Traditional Chinese Medicine (TCM), been practiced thousands years successfully used treat wide range ailments, including infectious diseases. Surprisingly, despite this extensive knowledge folk medicine, no plant-derived antibacterial drugs are currently approved use. As such, objective study evaluate antimicrobial properties extracts derived from TCM plants. Methods: This explores comprehensive library comprising 664 132 distinct plant species against gram-negative (Escherichia coli) gram-positive (Micrococcus luteus) bacteria using liquid solid vitro assays. Results: Intriguingly, our results reveal 17 with potent effective primarily Streptococcus aureus epidermidis. A literature search revealed 100 purified compounds plants were previously isolated confirmed their properties, collectively inhibiting 45 different bacterial species. Conclusions: Our indicate phytobiotics could serve potential candidates novel antimicrobials.

Язык: Английский

Процитировано

0