In vitro Evaluation of a pH-sensitive PCL-PAMAM G4 Nanocarrier for Co-Delivery of Silver Nanoparticles and Quercetin in MCF-7 Breast Cancer Cells
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 141524 - 141524
Опубликована: Янв. 1, 2025
Язык: Английский
Ciprofloxacin-encapsulated solid lipid nanoparticles: a comprehensive biochemical analysis of cytotoxic effects, proliferation inhibition, and apoptotic induction in KG1-a leukemia cells
Medical Oncology,
Год журнала:
2025,
Номер
42(3)
Опубликована: Фев. 13, 2025
Язык: Английский
Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Язык: Английский
Hyaluronic acid-functionalized carboxymethyl dextran-coated melatonin nanoconjugates for targeted etoposide delivery in metastatic colon cancer: Extensive in-vitro investigation in HCT116 cell lines, antimicrobial efficacy, and anti-angiogenic potential in chick chorioallantoic membrane (CAM) assay
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136373 - 136373
Опубликована: Окт. 11, 2024
Язык: Английский
Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives
Bhumi Shah,
Radhika Kachhadiya
Medicinal Chemistry Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Formulation of Morus alba extract loaded Solid Lipid Nanoparticles: In Silico , Characterizations, and In vitro cytotoxicity study
Drug Development and Industrial Pharmacy,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Дек. 9, 2024
Objective
This
study
aimed
to
formulate
Morus
alba
leaf
extract
(MAE)
loaded
solid
lipid
nanoparticles
(SLNs)
and
investigate
its
cytotoxic
potential
using
MDA-MB231
cell
line.Significance:
SLNs
can
protect
MAE
from
degradation,
enhance
cytotoxicity
potential,
making
them
suitable
for
various
therapeutic
areas.
Язык: Английский
Curcumin-Etoposide Synergy: Unveiling the Molecular Mechanisms of Enhanced Apoptosis and Chemoresistance Attenuation in Breast Cancer
Deleted Journal,
Год журнала:
2024,
Номер
23(1)
Опубликована: Ноя. 5, 2024
Combining
natural
compounds
with
chemotherapeutic
agents
has
emerged
as
a
promising
approach
for
cancer
treatment.
Curcumin
(Cur),
polyphenol,
is
known
its
anti-cancer
properties,
including
the
ability
to
induce
apoptosis
and
arrest
cell
cycle
progression.
This
study
aimed
evaluate
effects
of
Cur
etoposide
(ETO),
both
individually
in
combination,
on
induction
breast
(BC)
lines.
The
impact
ETO
proliferation
was
assessed
using
MTT
viability
assays.
Apoptosis
by
these
drugs
evaluated
through
Annexin
V
flow
cytometry
caspase-3
caspase-9
activity
Quantitative
real-time
PCR
employed
measure
Bax
Bcl-2
gene
expression
levels.
Western
blotting
conducted
determine
protein
levels
p53,
p21,
Bax,
Bcl-2.
A
non-significant
dose
selected
based
assay
results
combined
75
µM
Cur.
enhanced
ETO's
pro-apoptotic
effect
increasing
caspase
activities.
combination
significantly
reduced
while
upregulating
expression.
Furthermore,
treatment
this
elevated
compared
or
alone,
decreasing
potential
amplify
ETO-induced
BC
cells.
may
offer
therapeutic
BC.
Язык: Английский