Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Язык: Английский

Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis DOI Creative Commons

Zhiyan Liu,

Xueyang Shen,

Mingming Li

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis DOI
Yingjuan Liu, Guang Jia,

Sheng-Han Zhang

и другие.

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Язык: Английский

Процитировано

0
Advanced N-glycoproteomics and proteomics approach revealed sexually dimorphic molecular signatures in primary mouse hepatocyte DOI
Qian Yang, Yong Zhang, He Zhang

и другие.

Analytical and Bioanalytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Язык: Английский

Процитировано

0
Loss of Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Tumor Microenvironment and Response to BCG Immunotherapy in a Murine Orthotopic Model of Bladder Cancer DOI Open Access
Mugdha Vijay Patwardhan, Kane Toh, Edmund Chiong

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13296 - 13296

Опубликована: Дек. 11, 2024

Loss of the glutathione-S-transferases Theta 2 (Gstt2) expression is associated with an improved response to intravesical Mycobacterium bovis, Bacillus Calmette-Guérin (BCG) immunotherapy for non-muscle-invasive bladder cancer (NMIBC) patients who receive fewer BCG instillations. To delineate cause, Gstt2 knockout (KO) and wildtype (WT) C57Bl/6J mice were implanted tumors before treatment or saline. RNA was analyzed via single-cell sequencing (scRNA-seq) real-time polymerase chain reaction (RT-PCR). induced PD-L1 in WT bladders, while pro-inflammatory TNF-α upregulated KO bladders. ScRNA-seq analysis showed that bladders had a higher proportion matrix remodeling fibroblasts, M2 macrophages, neuronal cells. In mice, distinct tumor cell types, activated M1 macrophages enriched genes expressed supported tumorigenesis immunosuppressive expression. contrast, involved inflammation, immune activation, suppression. An 11-gene signature (Hmga2, Peak 1, Kras, Slc2a1, Ankfn1, Ahnak, Cmss1, Fmo5, Gphn, Plec, Gstt2), derived from scRNA-seq predicted NMIBC (The Cancer Genome Atlas (TCGA) database). conclusion, our results indicate may benefit anti-PD-L1 checkpoint inhibition therapy.

Язык: Английский

Процитировано

1
Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Язык: Английский

Процитировано

0