Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candidaparapsilosis and Candidozyma auris

Biomolecules, Год журнала: 2025, Номер 15(3), С. 322 - 322

Опубликована: Фев. 21, 2025

Biofilms are the predominant lifeforms of microorganisms, contributing to over 80% infections, including those caused by Candida species like C. albicans, parapsilosis and Candidozyma auris. These form biofilms on medical devices, making infections challenging treat, especially with rise in drug-resistant strains. particularly hospital-acquired ones, a significant health threat due their resistance antifungals risk developing systemic (i.e., sepsis). We have previously shown that C14R reduces viability albicans auris, but not parapsilosis. Here, we show only inhibits pore formation, resazurin reduction assay, fluorescence-based permeabilization it also halts biofilm maturation significantly biomass preformed 70%. findings suggest could be an effective option for treating severe fungal offering potential new treatment approach biofilm-related diseases. Further research is needed fully understand its dispersal optimize use future applications as antifungal clinical settings.

Язык: Английский

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Transparent exopolymer particles as bacteria shuttle to initialize the biofilm development on membrane during filtration process

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132344 - 132344

Опубликована: Март 1, 2025

Язык: Английский

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A novel quality-by-design assisted HPLC-DAD method for the simultaneous quantification of tryptophan, tryptophol, and voriconazole for early diagnosis and prognosis of fungal infections decoding quorum sensing phenomenon

Journal of Chromatography B, Год журнала: 2025, Номер unknown, С. 124571 - 124571

Опубликована: Март 1, 2025

Язык: Английский

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Microbial biofilms as a platform for diverse biocatalytic applications

Bioresource Technology, Год журнала: 2024, Номер 411, С. 131302 - 131302

Опубликована: Авг. 22, 2024

Язык: Английский

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Integrative analysis of transcriptome and metabolome profiling uncovers underlying mechanisms of the enhancement of the synthesis of biofilm in Sporobolomyces pararoseus NGR under acidic conditions

Microbial Cell Factories, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 7, 2025

Sporobolomyces pararoseus is a well-studied oleaginous red yeast that can synthesize variety of high value-added bioactive compounds. Biofilm one the important biological barriers for microbial cells to resist environmental stresses and maintain stable fermentation process. Here, effect acidic conditions on biosynthesis biofilms in S. NGR was investigated through combination morphology, biochemistry, multi-omics approaches. The results showed environment key factor trigger biofilm formation NGR. When cultured under pH 4.7, colony morphology wrinkled, were wrapped by large amount extracellular matrix, hydrophobicity anti-oxidative stress ability significantly improved, yield intracellular carotenoids increased. Transcriptome metabolome profiling indicated carbohydrate metabolism, amino acid lipid nucleic metabolism enriched 4.7 culture conditions, including 56 differentially expressed genes 341 differential metabolites. These metabolites may play an role response stress. will provide strategies development utilization beneficial biofilms, theoretical support industrial production microorganisms improve their resistance growth.

Язык: Английский

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The high-osmolarity glycerol (HOG) pathway in Candida auris

mBio, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

ABSTRACT The emerging fungal pathogen Candida auris is known for its strong skin tropism and resilience against antifungal disinfection treatment, posing a significant challenge healthcare units. Although efforts to identify the effectors of unique pathogenic behavior have been insightful, role high-osmolarity glycerol (HOG) pathway in this context remains unexplored. study by Shivarathri co-workers (R. Shivarathri, M. Chauhan, A. Datta, D. Das et al., mBio 15:e02748-24, 2024, https://doi.org/10.1128/mbio.02748-24 ) sought address gap. This report indeed advances our understanding critical HOG C. pathogenicity emphasizing involvement colonization, biofilm formation, evasion phagocyte attack.

Язык: Английский

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How pathogens drive adipose tissue loss in the host

Current Opinion in Microbiology, Год журнала: 2025, Номер 85, С. 102597 - 102597

Опубликована: Март 12, 2025

Weight loss is a hallmark of many infections, including those caused by bacteria, fungi and parasites. This often attributed to infection-induced anorexia the need mobilise energy from internal sources cope with pathogens. during infection results significant reduction muscle fat mass, two organs that together account for approximately 60% body mass in healthy state. While wasting well-documented aspect infection-related weight loss, adipose tissue via lipolysis also plays critical role can determine disease outcomes. review explores regulators depletion excessive infection, probable mechanisms, potential consequences host survival pathogen fitness.

Язык: Английский

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Clinical aspects and recent advances in fungal diseases impacting human health

Journal of Antimicrobial Chemotherapy, Год журнала: 2025, Номер 80(Supplement_1), С. i2 - i8

Опубликована: Март 1, 2025

Abstract Fungal diseases are of growing clinical concern in human medicine as the result changes epidemiology, diversity presentation, emergence new pathogens, difficulties diagnosis and increasing resistance to antifungals current available classes. There is a need for high disease awareness among public healthcare physicians, improvement diagnostic methods development drugs from therapeutic classes with an improved profile. In this article, we will explore some key aspects fungal humans provide general overview important topic.

Язык: Английский

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Current knowledge on the dual species interaction and biofilm between Aspergillus and Bacillus : exploiting molecular understanding toward applications

Critical Reviews in Microbiology, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Март 28, 2025

The complex interaction between Aspergillus and Bacillus has been gaining attention with the evolution of their co-culture applications. Information reported on this from different points view including both synergistic antagonistic mechanisms necessitates a review for better understanding. This focuses interaction, biofilm formation, diverse biotechnological applications Bacillus, giving special to niger subtilis. demonstrates that co-cultivation exhibits significant transcriptional changes, impacting metabolism secondary metabolite production in organisms. Signaling living fungal hyphae, EPS production, TasA fibrils, regulators like Spo0A are essential forming communities. Nutrient availability pH levels, species type, mutations EPS-producing genes may also influence whether will act antagonistically or synergistically Aspergillus. dual-nature activates silent synthesizing novel compounds mainly antifungal medicinal properties, showcasing its potential various fields such as agriculture crop protection, bioremediation, environmental biotechnology, food science fermentation, industrial medical biotechnology health. use evolved simple monoculture more sophisticated co-cultures trending toward synergy metabolic optimization.

Язык: Английский

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Construction of an efficient enzyme-cell@material biocatalyst through the biofilm immobilization of Komagataella phaffii for continuous biocatalysis

Bioresource Technology, Год журнала: 2025, Номер unknown, С. 132460 - 132460

Опубликована: Март 1, 2025

Язык: Английский

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