SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer
Results in Chemistry,
Год журнала:
2025,
Номер
unknown, С. 102113 - 102113
Опубликована: Фев. 1, 2025
Язык: Английский
Innovative nanodelivery systems for targeted breast cancer therapy: overcoming drug delivery challenges and exploring future perspectives
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Язык: Английский
Research progress of nano drug delivery systems in the anti-tumor treatment of traditional Chinese medicine monomers
PeerJ,
Год журнала:
2025,
Номер
13, С. e19332 - e19332
Опубликована: Апрель 24, 2025
Tumors
pose
a
serious
threat
to
global
public
health
and
are
usually
treated
from
two
aspects:
tumor
cells
microenvironment.
Compared
with
traditional
chemotherapy
drugs,
Chinese
medicine
(TCM)
monomers
have
advantages
in
treatment,
such
as
multiple
targets,
levels
synergistic
intervention.
However,
most
TCM
active
ingredients
disadvantages
poor
water
solubility
stability,
which
restrict
their
clinical
application.
Nano
drug
delivery
systems
the
functions
of
improving
bioavailability
anti-tumor
ingredients,
enhancing
tissue
targeting,
achieving
controlled
release,
inhibiting
multidrug
resistance.
free
monomers,
they
higher
therapeutic
effects
fewer
side
effects.
This
article
summarizes
five
commonly
used
monomer
nanocarriers,
including
lipid
nanomaterials,
exosomes,
polymer
micelles,
carbon
nanotubes,
dendrimers,
explains
mechanisms
after
combining
TCM,
cell
proliferation
metastasis,
regulating
microenvironment,
etc
.
At
same
time,
potential
nano
combined
radiotherapy
immunotherapy
is
discussed,
well
current
problems
toxicity,
long-term
complex
amplification
process,
future
development
directions,
aiming
provide
reference
for
promoting
application
ingredients.
Язык: Английский
DFT and Molecular Docking Study of HA-Conjugated SWCNTs for CD44-Targeted Delivery of Platinum-Based Chemotherapeutics
Pharmaceuticals,
Год журнала:
2025,
Номер
18(6), С. 805 - 805
Опубликована: Май 27, 2025
Background:
Hyaluronicacid
(HA)-conjugated
nanocarriers
leverage
CD44
receptor
overexpression
on
tumor
cells
for
targeted
delivery
of
platinum
chemotherapeutics.
Methods:
This
study
compares
non-functionalized
(DDS1)
versus
HA-conjugated
single-walled
carbon
nanotubes
(DDS2)
encapsulation
stability
and
binding
Cisplatin,
Carboplatin,
Lobaplatin.
Density
Functional
Theory
calculations
employed
PBE-GGA
with
Tkatchenko–Scheffler
dispersion
ZORA
relativistic
treatment,
using
a
finite
(8,8)
armchair
SWCNT
(24.6
Å,
H-capped)
DDS1
an
EDC/NHS-coupled
HA
oligomer
DDS2.
We
computed
energies,
HOMO–LUMO
gaps,
Molecular
Electrostatic
Potentials,
energy
decompositions.
docking
to
(PDB
ID:
4PZ3)
used
Molegro
Virtual
Docker,
validated
by
re-docking
the
native
fragment
(RMSD
1.79
Å).
Results:
DFT
energies
(eV)
DDS2
were
−7.92/−7.48
(Cisplatin),
−8.93/−8.30
(Carboplatin),
−9.72/−9.25
(Lobaplatin),
indicating
enhanced
stabilization
functionalization.
Energy
decomposition
showed
increases
∼0.4
eV
(vdW)
∼0.2
(electrostatic)
in
MEP
maps
confirmed
additional
negative-potential
regions
DDS2,
complementing
drug-positive
sites.
yielded
MolDock
scores
−171.26
−106.68
DDS1,
reflecting
stronger
affinity.
Docking
indicate
that
conjugation
notably
strengthens
predicted
affinity
CNT
carriers
toward
(ΔScore
≈
−65
kcal
mol−1).
Conclusions:
These
results
motivate
experimental
follow-up
confirm
whether
can
translate
silico
gains
into
improved
Язык: Английский