Antibacterial evaluation of antibiotic-coated titanium and stainless steel implants in orthopaedic application: a dip-coating approach
Journal of Orthopaedic Surgery and Research,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 10, 2025
Despite
their
biocompatibility,
metal
implants
are
susceptible
to
infections,
leading
implant
failure
and
patient
complications.
The
purpose
of
this
study
was
investigate
the
antibacterial
potential
antibiotic-coated
titanium
stainless
steel
implants.
designed
as
an
experimental
in
vitro
study,
it
conducted
at
Department
Immunology
University
Health
Sciences,
Istanbul/
Turkiye
January
February
2024.
Pieces
were
coated
with
gentamicin,
teicoplanin,
rifampicin
a
combination
gentamicin
using
dipping
method.
Antibacterial
activity
against
Staphylococcus
epidermidis
aureus
assessed
zone
inhibition
(ZOI)
measurements.
Both
displayed
significant
ZOI
values
for
all
antibiotic
treatments,
indicating
effective
bacterial
growth.
exhibited
largest
both
Antibiotic-coated
demonstrate
promising
reducing
implant-associated
infections.
Further
research
is
needed
optimise
coating
method,
explore
therapies
evaluate
long-term
efficacy
approach
clinical
settings.
Язык: Английский
Screening of Anti‐Biofilm Compounds From Paeoniae Radix Alba Based on Oral Biofilm Biochromatography
Biomedical Chromatography,
Год журнала:
2025,
Номер
39(4)
Опубликована: Март 9, 2025
Oral
biofilms,
which
are
known
as
dental
plaque,
the
reason
for
a
wide
range
of
oral
and
systemic
diseases,
contribute
to
serious
health
risks.
Paeoniae
Radix
Alba
(PRA)
is
traditionally
used
folk
medicine
with
anti-inflammatory,
cardioprotective,
hepatoprotective
properties.
PRA
currently
in
variety
therapeutic
approaches
diseases.
Nevertheless,
its
inhibitory
effect
on
biofilm
formation
basis
efficacy
have
not
been
clarified.
This
study
intended
screen
potential
compounds
that
inhibit
using
biochromatography.
Two
models
based
S.
mutans
were
determine
formation.
The
extraction
was
divided
into
fractions
different
polarity,
active
fraction
screened,
an
HPLC
profile
constructed
fraction.
Three
screened
targeted
extraction,
subsequent
validation
indicated
albiflorin
main
compound
exerting
anti-biofilm
activity.
Our
results
revealed
pharmacological
substance
inhibiting
provide
reference
further
use
development
products.
Язык: Английский