Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 30, 2025

Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, despite advancements in acute intervention rehabilitation strategies. Traditional, Complementary, Integrative Medicine (TCIM) systems; including herbal medicine, acupuncture, mind-body interventions are increasingly being explored as adjunct therapies management. This narrative review evaluates the current evidence supporting TCIM approaches for ischemic stroke, highlighting their potential neuroprotective, anti-inflammatory, antioxidant, cerebrovascular effects. Particular emphasis is placed on well-studied botanical such Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma], Ginkgo biloba L. [Ginkgoaceae; folium], Panax ginseng C.A. Mey. [Araliaceae; Ginseng radix]. The discusses mechanisms action, clinical trial outcomes, integration challenges, while underscoring need standardization, quality control, rigorous scientific validation. work aims to support informed decisions regarding evidence-based practices into conventional care protocols.

Язык: Английский

Role of Akkermansia muciniphila in insulin resistance

Journal of Gastroenterology and Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 13, 2024

Abstract Insulin resistance (IR) is a pathogenic factor in numerous metabolic diseases. The gut microbiota plays crucial role maintaining the function of intestinal barrier and overall human health, thereby influencing IR. Dysbiosis can contribute to development Therefore, it essential maintain balanced diverse for optimal health. Akkermansia muciniphila , widely present microorganism intestine, has been shown regulate gastrointestinal mucosal integrity, reduce endotoxin penetration, decrease systemic inflammation levels, improve insulin sensitivity. Reduced abundance A. associated with an increased risk IR other diseases, highlighting its correlation Understanding regulatory mechanism comprehending pathogenesis developing novel strategies preventing treating related disorders. Individual variations may exist both composition impact on among different individuals. Further investigation into individual differences between will facilitate advancements personalized medicine by promoting tailored interventions based composition, which potential future direction that would optimize sensitivity while disease occurrence. In this review, we describe physiological characteristics emphasize roles underlying mechanisms contributing pathology, summarize how alterations affect development, providing valuable insights further research as well new drug targeting diabetes.

Язык: Английский