Journal of Gastroenterology and Hepatology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 13, 2024
Abstract Insulin resistance (IR) is a pathogenic factor in numerous metabolic diseases. The gut microbiota plays crucial role maintaining the function of intestinal barrier and overall human health, thereby influencing IR. Dysbiosis can contribute to development Therefore, it essential maintain balanced diverse for optimal health. Akkermansia muciniphila , widely present microorganism intestine, has been shown regulate gastrointestinal mucosal integrity, reduce endotoxin penetration, decrease systemic inflammation levels, improve insulin sensitivity. Reduced abundance A. associated with an increased risk IR other diseases, highlighting its correlation Understanding regulatory mechanism comprehending pathogenesis developing novel strategies preventing treating related disorders. Individual variations may exist both composition impact on among different individuals. Further investigation into individual differences between will facilitate advancements personalized medicine by promoting tailored interventions based composition, which potential future direction that would optimize sensitivity while disease occurrence. In this review, we describe physiological characteristics emphasize roles underlying mechanisms contributing pathology, summarize how alterations affect development, providing valuable insights further research as well new drug targeting diabetes.
Язык: Английский