Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis

Science Advances, Год журнала: 2024, Номер 10(42)

Опубликована: Окт. 16, 2024

A major therapeutic barrier in melanoma is the coexistence of diverse cellular states marked by distinct metabolic traits. Transitioning from a proliferative to an invasive phenotype coupled with increased ferroptosis vulnerability. However, regulatory circuits controlling susceptibility across cell are unknown. In this work, we identified Apolipoprotein E ( APOE ) as top lipid-metabolism gene segregating MITF high /AXL low proliferative/ferroptosis-resistant invasive/ferroptosis-sensitive state. Mechanistically, ApoE secreted cells protects ferroptosis-inducing agents reducing content peroxidation-prone polyunsaturated fatty acids and boosting GPX4 levels both vitro vivo. Whole-exome sequencing indicates that expression patients associated resistance ferroptosis, regardless germline status. aggregate, found ferroptosis-resistance mechanism between relying on potential biomarker for poor response melanoma.

Язык: Английский

Research progress on ferroptosis in Myelodysplastic syndromes

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 28, 2025

Myelodysplastic syndromes (MDS) are a group of malignancies characterized by clonal proliferation hematopoietic stem cells, ineffective hematopoiesis, peripheral cytopenias, and high risk transformation to acute myeloid leukemia. Current therapeutic strategies for MDS have limited efficacy. Thus, identifying new targets prognostic biomarkers is critical future research direction. Ferroptosis, type iron-dependent programmed cell death, has become recent hotspot in the field oncology research. Recent results demonstrated that iron metabolism, lipid other pathways can be targeted induce ferroptosis cells. In addition, ferroptosis-related genes significance prognosis diagnosis MDS. This article reviews current progress on MDS, including its potential targeting as intervention strategy.

Язык: Английский

Regulatory mechanism of Elovl6 in lipid metabolism, antioxidant capacity, and immune function in Scylla paramamosain revealed by Ap-1

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137700 - 137700

Опубликована: Ноя. 1, 2024

Язык: Английский