The impact of the mRNA COVID-19 vaccine on the Th-like cytokine profile in individuals with no history of COVID-19: insights into autoimmunity targeting heat shock proteins

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 14, 2025

Although some reports suggest that COVID-19 vaccination may exacerbate existing autoimmune diseases or trigger new-onset cases, a definitive causal relationship between the vaccines and these conditions has not been established. Several potential mechanisms have proposed to explain this association, including: (i) molecular mimicry, which refers structural similarity SARS-CoV-2 human antigens; (ii) bystander activation, involving both B T lymphocytes; (iii) effects of adjuvants. In study, we investigated whether two doses mRNA vaccine influenced blood cytokine levels associated with major helper cell populations, are known play significant role in autoimmunity revisited humoral response directed against heat shock proteins (Hsps) individuals no history COVID-19. While differences were found IFN-γ, IL-6, IL-22, IL-4, IL-8, IL-10, IL-17A, vaccinated unvaccinated people, several positive correlations observed serum circulating autoantibodies self-Hsps exclusively individuals. These findings does impact cytokines involved pathogenesis diseases. Further research is required evaluate safety patients conditions, particularly those whom anti-Hsps suspected contribute disease development.

Язык: Английский

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Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11624 - 11624

Опубликована: Окт. 29, 2024

Extensive research has been conducted on the SARS-CoV-2 virus in association with various infectious diseases to understand pathophysiology of infection and potential co-infections. In tropical countries, exposure local viruses may alter course coinfection. Notably, only a portion antibodies produced against proteins demonstrate neutralizing properties, immune response following natural tends be temporary. contrast, long-lasting IgG are common after dengue infections. cases where preexisting from an initial bind different serotype during subsequent infection, there is for antibody-dependent enhancement (ADE) formation complexes associated disease severity. Both infections can result immunodeficiency. Viral both interfere host's IFN-I signaling. Additionally, cytokine storm occur viral impairing proper response, autoantibodies wide array appear convalescence. Most reported typically short-lived. Vaccines affecting enhancing clearance. A comprehensive analysis pathogenicity revisited prevent severity, mortality.

Язык: Английский

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Recent Advances in TGF-β Signaling Pathway in COVID-19 Pathogenesis: A review

Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107236 - 107236

Опубликована: Дек. 1, 2024

Язык: Английский

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Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity

Heliyon, Год журнала: 2024, Номер 11(1), С. e41267 - e41267

Опубликована: Дек. 18, 2024

Язык: Английский

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