Chemoresistance and the tumor microenvironment: the critical role of cell–cell communication

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 10, 2024

Resistance of cancer cells to anticancer drugs remains a major challenge in modern medicine. Understanding the mechanisms behind development chemoresistance is key developing appropriate therapies counteract it. Nowadays, with advances technology, we are paying more and attention role tumor microenvironment (TME) intercellular interactions this process. We also know that important elements TME not only themselves but other cell types, such as mesenchymal stem cells, cancer-associated fibroblasts, stromal macrophages. can communicate each indirectly (via cytokines, chemokines, growth factors, extracellular vesicles [EVs]) directly gap junctions, ligand-receptor pairs, adhesion, tunnel nanotubes). This communication appears be critical for chemoresistance. EVs seem particularly interesting structures regard. Within these structures, lipids, proteins, nucleic acids transported, acting signaling molecules interact numerous biochemical pathways, thereby contributing Moreover, drug efflux pumps, which responsible removing from transported via EVs.

Язык: Английский

Mendelian randomization reveals immune cell composition as a key determinant of cervical cancer prognosis

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 29, 2025

Язык: Английский