26‐Week Repeated‐Dose Toxicity Study of a Novel Antiarrhythmic Drug Sulcardine Sulfate in Sprague–Dawley Rats

Journal of Applied Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Sulcardine sulfate (Sul) is a novel antiarrhythmic agent blocking multiple channels and exhibits unique pharmacological properties such as lower APD-dependent prolongation reduced arrhythmia risk. Sul currently in Phase III clinical trials, yet studies on its long-term toxicological profile potential target organs remain unexplored. This study investigated the related toxicity of Sprague Dawley (SD) rats through repeated oral administration for 26 weeks, followed by 4-week recovery period. Consistent with intended mode administration, was administered via gavage at daily doses 0, 175, 350, 700/525 mg/kg rats. On account clinically observed body weight loss male female high-dose group compared control group, one rat dying after 8 weeks high dose adjusted to 525 mg/kg. Aspartate aminotransferase (AST) alanine (ALT) levels significantly increased medium- groups, whereas these groups showed significant rise alkaline phosphatase (ALP) levels, accompanied varying degrees gain liver lungs. Additionally, brownish-red pigment deposition hepatocytes Kupffer cells across all dosing along foam cell alveolar cavities. Concomitant toxicokinetics that drug accumulated some extent animals. Consequently, lungs were identified organs, no adverse effect level (NOAEL) determined be 175

Язык: Английский

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Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119803 - 119803

Опубликована: Апрель 1, 2025

Язык: Английский

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Fuling Wenxin Formula Treats "Qi-Yin Deficiency" Arrhythmia by Regulating the Dilated Cardiomyopathy and Adrenergic Signaling Pathway in Cardiomyocytes

Phytomedicine, Год журнала: 2025, Номер 142, С. 156812 - 156812

Опубликована: Апрель 27, 2025

Язык: Английский

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Traditional Chinese Medicine for Anti‐Arrhythmias: Mechanisms via Potassium Channels

Basic & Clinical Pharmacology & Toxicology, Год журнала: 2025, Номер 137(1)

Опубликована: Июнь 3, 2025

ABSTRACT Cardiac arrhythmia is a common life‐threatening cardiovascular disorder. Potassium channels play crucial role in cardiac electrophysiology, and their dysfunction closely associated with the occurrence development of arrhythmia. Traditional Chinese medicine (TCM) has long‐standing history treating various diseases, including offers rich source compounds for anti‐arrhythmic drugs. To provide in‐depth new insights novel therapies, this review delves into effects TCM on potassium through multiple ways, direct interaction between active ingredients contained channels, regulation expression related genes proteins, intervention intracellular signalling pathways exertion antioxidant anti‐inflammatory effects. With continued efforts standardization, research integration Western medicine, playing an increasingly important treatment provides options patients worldwide. Phenomics pharmacophenomics as well artificial intelligence–based GPCR ligand screening system may paradigms platforms discovering developing more

Язык: Английский

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Multi-Faceted Potential of Sophoridine Compound's Anti-Arrhythmic and Antioxidant Effects through ROS/CaMKII Pathway

Heliyon, Год журнала: 2024, Номер 10(18), С. e37542 - e37542

Опубликована: Сен. 1, 2024

Язык: Английский

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