Advances in Stem Cell Therapy: A Hope for Regenerative Medicine DOI Creative Commons
Naveed Shuja

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 1 - 3

Опубликована: Дек. 18, 2024

Introduction Regenerative medicine has become a light at the end of tunnel for countless patients who have suffered from diseases previously considered incurable. Stem cell therapy is central to this revolutionary progress and already made huge advances in recent years. cells potential regenerate tissues, repair organs, even modulate immune responses, making them key delivering innovative treatments broad spectrum medical conditions. This editorial describes stem as well its promise regenerative medicine[1]. Cells unique Properties. properties that make great value therapeutic applications. allows self-renew differentiate into specialized types with immense possibilities being used treating degenerative diseases, tissue injuries, genetic disorders. Each type classified broadly embryonic (ESCs), adult (ASCs), induced pluripotent (iPSCs) particular advantages. For example, ESCs are can almost any type, while more accessible less ethically controversial MSCs like ASCs[2]. Pioneered most recently by Shinya Yamanaka, breakthroughs iPSC technology further revolutionized field. IpsCs overcome many limitations reprogramming somatic state. It accelerated development patient-specific therapies – personalized solutions[3]. Cell Therapy Success Stories had tremendous success multiple different Therapies also been shown be effective Parkinson’s disease, spinal cord stroke neurological Damaged neurons replaced transplanted lost functions restored[4]. While clinical trials using iPSCs recovery revealed improved motor function reduced inflammation, they represent leap forward Repairing damaged heart results myocardial infarction explored cardiomyocyte transplantation iPSCs. In preclinical studies, these not only support regeneration but enhance cardiac survival outcomes[5]. The differentiation insulin-secreting β use treatment type- 1 diabetes represents another major milestone therapy. But bloodstream regulate blood glucose levels, last, realistic prospect cure[6, 7]. Unfortunately, hematopoietic (HSCT) remains gold standard blood-related disorders, such leukemia, aplastic anemia, deficiencies. HSCT safer gene editing technologies CRISPR-Cas9, which now allow targeted therapies. widely investigated orthopedic field their cartilage, bone, muscle tissue. lot osteoarthritis, fractures, tendon where help speed up healing reduce pain[8]. Challenges Sure, undeniable, host challenges must first it mainstream tool. Despite all this, safety concerns remain paramount: tumorigenesis, rejection, unintended differentiation. Equally important standardization regulation, will develop consistent protocols isolation, culture, reproducible outcomes trials. addition, very expensive, limits access, especially low middle-income countries. However, continued raise ethical concerns, particularly area ESCs, therefore alternative sources needed[9]. Future Directions Overcoming future challenge bioengineering, nanotechnology, editing. 3D bio-printed tissues organoids bring together engineering provide functional transplantation. These innovations could change way we deal organ failure advanced conditions[10]. Conclusion enters new era progressive continuous progress. With expansion increasing technology, transform landscape injuries. Still, there plenty work done, convergence interdisciplinary presents strong foundation hope. participation scientists, clinicians, policymakers, industry stakeholders, research translated safe, effective, benefiting millions possibility recover improve quality life. promising center Through innovation addressing current challenges, unleash full power transformative solutions around world.

Язык: Английский

Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting DOI Creative Commons
Kirolos Eskandar

Regenesis repair rehabilitation., Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications DOI Open Access
Andrew Goulian,

Barry Goldstein,

Maarouf Saad

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2061 - 2061

Опубликована: Март 18, 2025

Background/Objectives: Regenerative therapies have gained interest in orthopedic applications for their potential to enhance tissue regeneration, functional recovery, and pain modification. This review evaluates the clinical efficacy of platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), peptide-based treatments, biomimetic materials care, with a focus on reduction outcomes. Methods: A structured literature search PubMed (January 2009–January 2025) identified 160 studies. After applying inclusion criteria prioritizing randomized controlled trials (RCTs) trials, 59 studies were included: 20 PRP, MSCs, 10 peptide therapies, 7 biomimetics. Data extraction focused risk bias assessed using Cochrane Risk Bias (RoB) tool ROBINS-I tool. random-effects meta-regression analysis was conducted evaluate impact therapy type, sample size, reported Results: Meta-regression MSC as most effective intervention (β = 8.45, p < 0.05), PRP showing moderate improvements, demonstrating lowest effect. provided short-term relief, particularly acute injuries tendon repair, though inconsistencies preparation methods limited success chronic conditions. demonstrated cartilage regeneration early osteoarthritis improvement, but high costs ethical concerns remain barriers widespread adoption. Peptide-based materials, including engineered scaffolds autologous protein solutions, showed promise infection control wound healing, further research is needed optimize dosing, delivery methods, long-term safety. Conclusions: offer significant reliable regenerative effects, providing symptomatic treatments emerging promising adjuncts. However, standardized protocols large-scale are establish improve translation broader

Язык: Английский

Процитировано

0
Innovative approaches to treatment of eye diseases: advances in stem cell therapy use in ophthalmology DOI

Victor Oluwatomiwa Ajekiigbe,

Chinonyelum Emmanuel Agbo,

Ikponmwosa Jude Ogieuhi

и другие.

International Ophthalmology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

0
Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission DOI

S Habibi,

Shabbou Bahramian,

Saeedeh Zare Jalise

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104715 - 104715

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases DOI

Zahra Khademi,

Negar Mottaghi-Dastjerdi, Hamed Morad

и другие.

Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103816 - 103816

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Advancements in Biomaterials for Stem Cell Differentiation DOI
Meiying Shao,

Mohamad Rahmdel,

Sepideh Karkon Shayan

и другие.

Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

Процитировано

0
Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development DOI
José Mauro Granjeiro, Priscila Grion de Miranda Borchio,

I. Ribeiro

и другие.

World Journal of Stem Cells, Год журнала: 2024, Номер 16(10), С. 860 - 872

Опубликована: Окт. 24, 2024

The burgeoning field of bioengineering has witnessed significant strides due to the advent stem cell models, particularly in their application advanced therapy medicinal products (ATMPs). In this review, we examine multifaceted impact these developments, emphasizing potential models enhance sophistication ATMPs and offer alternatives animal testing. Stem cell-derived tissues are promising because they can reshape preclinical landscape by providing more physiologically relevant ethically sound platforms for drug screening disease modelling. We also discuss critical challenges reproducibility accuracy measurements ensure integrity utility research application. Moreover, review highlights imperative align with regulatory standards, ensuring using cells translates into safe effective clinical therapies. With approval serving as a gateway adoption, collaborative efforts between scientists regulators vital progression applications from bench bedside. advocate balanced approach that nurtures innovation within framework rigorous validation compliance, cell-base solutions maximized promote public trust patient health ATMPs.

Язык: Английский

Процитировано

2
Nanotechnology at the Crossroads of Stem Cell Medicine DOI

Sweny Jain,

Jay Bhatt, Sharad Gupta

и другие.

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Nanotechnology in stem cell medicine is an interdisciplinary field which has gained a lot of interest recently.

Язык: Английский

Процитировано

0
Advances in Stem Cell Therapy: A Hope for Regenerative Medicine DOI Creative Commons
Naveed Shuja

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 1 - 3

Опубликована: Дек. 18, 2024

Introduction Regenerative medicine has become a light at the end of tunnel for countless patients who have suffered from diseases previously considered incurable. Stem cell therapy is central to this revolutionary progress and already made huge advances in recent years. cells potential regenerate tissues, repair organs, even modulate immune responses, making them key delivering innovative treatments broad spectrum medical conditions. This editorial describes stem as well its promise regenerative medicine[1]. Cells unique Properties. properties that make great value therapeutic applications. allows self-renew differentiate into specialized types with immense possibilities being used treating degenerative diseases, tissue injuries, genetic disorders. Each type classified broadly embryonic (ESCs), adult (ASCs), induced pluripotent (iPSCs) particular advantages. For example, ESCs are can almost any type, while more accessible less ethically controversial MSCs like ASCs[2]. Pioneered most recently by Shinya Yamanaka, breakthroughs iPSC technology further revolutionized field. IpsCs overcome many limitations reprogramming somatic state. It accelerated development patient-specific therapies – personalized solutions[3]. Cell Therapy Success Stories had tremendous success multiple different Therapies also been shown be effective Parkinson’s disease, spinal cord stroke neurological Damaged neurons replaced transplanted lost functions restored[4]. While clinical trials using iPSCs recovery revealed improved motor function reduced inflammation, they represent leap forward Repairing damaged heart results myocardial infarction explored cardiomyocyte transplantation iPSCs. In preclinical studies, these not only support regeneration but enhance cardiac survival outcomes[5]. The differentiation insulin-secreting β use treatment type- 1 diabetes represents another major milestone therapy. But bloodstream regulate blood glucose levels, last, realistic prospect cure[6, 7]. Unfortunately, hematopoietic (HSCT) remains gold standard blood-related disorders, such leukemia, aplastic anemia, deficiencies. HSCT safer gene editing technologies CRISPR-Cas9, which now allow targeted therapies. widely investigated orthopedic field their cartilage, bone, muscle tissue. lot osteoarthritis, fractures, tendon where help speed up healing reduce pain[8]. Challenges Sure, undeniable, host challenges must first it mainstream tool. Despite all this, safety concerns remain paramount: tumorigenesis, rejection, unintended differentiation. Equally important standardization regulation, will develop consistent protocols isolation, culture, reproducible outcomes trials. addition, very expensive, limits access, especially low middle-income countries. However, continued raise ethical concerns, particularly area ESCs, therefore alternative sources needed[9]. Future Directions Overcoming future challenge bioengineering, nanotechnology, editing. 3D bio-printed tissues organoids bring together engineering provide functional transplantation. These innovations could change way we deal organ failure advanced conditions[10]. Conclusion enters new era progressive continuous progress. With expansion increasing technology, transform landscape injuries. Still, there plenty work done, convergence interdisciplinary presents strong foundation hope. participation scientists, clinicians, policymakers, industry stakeholders, research translated safe, effective, benefiting millions possibility recover improve quality life. promising center Through innovation addressing current challenges, unleash full power transformative solutions around world.

Язык: Английский

Процитировано

0