Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 19, 2025
Язык: Английский
Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
Biology,
Год журнала:
2025,
Номер
14(2), С. 185 - 185
Опубликована: Фев. 11, 2025
The
Wnt/β-catenin
pathway
takes
part
in
important
cellular
processes
tumor
cells,
such
as
gene
expression,
adhesion,
and
survival.
canonical
is
activated
several
tumors,
β-catenin
its
major
effector.
union
of
Wnt
to
the
co-receptor
complex
causes
inhibition
GSK3β
activity,
thus
preventing
phosphorylation
degradation
β-catenin,
which
accumulates
cytoplasm,
subsequently
be
transported
nucleus
associate
with
transcription
factors.
relationship
between
DNA
damage/repair
mechanisms
has
been
a
focus
for
last
few
years.
Studying
network
interactions
proteins
become
successful
research
field.
This
review
provides
an
overview
participation
their
future
implications
targets
cancer
therapy.
Язык: Английский
Lipopolysaccharide-Induced Inflammatory Response and Its Prominent Suppression by Paspalum thunbergii Extract
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1611 - 1611
Опубликована: Фев. 13, 2025
The
extract
of
Paspalum
thunbergii,
a
native
perennial
herb
in
Korea
belonging
to
the
rice
family,
was
investigated
for
its
anti-inflammatory
activity
and
underlying
mechanisms
driving
effects.
Fifteen
chemical
components
P.
thunbergii
extract,
including
rosmarinic
acid
isoquercitrin,
were
identified
using
LC-MS.
showed
antioxidative
through
DPPH
ABTS
cation
radical
scavenging
activity.
significantly
inhibited
lipopolysaccharide
(LPS)-induced
nitric
oxide
(NO)
production
macrophage
RAW
264.7
cells.
expression
lipopolysaccharide-induced
iNOS
COX-2,
which
are
inflammation-related
enzymes.
To
explore
mechanism,
levels
signal
proteins
related
MAPK,
NF-κB,
JAK/STAT,
Wnt/β-catenin
signaling
measured.
As
result,
p-p38,
p-JNK
increased
by
LPS
Additionally,
it
decreased
LPS-induced
p-IKKβ
p-NF-κB
p65
prevented
migration
into
nucleus
caused
LPS.
Notably,
p-JAK1,
p-STAT3,
Wnt
3α,
β-catenin,
p-GSK-3β
protein
expressions
also
inhibited.
Therefore,
prominent
may
be
via
pathway.
Язык: Английский
Advances in Targeted and Chemotherapeutic Strategies for Colorectal Cancer: Current Insights and Future Directions
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 642 - 642
Опубликована: Март 5, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
leading
causes
cancer-related
mortality
worldwide,
necessitating
continuous
evolution
therapeutic
approaches.
Despite
advancements
in
early
detection
and
localized
treatments,
metastatic
colorectal
(mCRC)
poses
significant
challenges
due
to
low
survival
rates
resistance
conventional
therapies.
This
review
highlights
current
landscape
CRC
treatment,
focusing
on
chemotherapy
targeted
Chemotherapeutic
agents,
including
5-fluorouracil,
irinotecan,
oxaliplatin,
have
significantly
improved
but
face
limitations
such
as
systemic
toxicity
resistance.
Targeted
therapies,
leveraging
mechanisms
like
VEGF,
EGFR,
Hedgehog
pathway
inhibition,
offer
promising
alternatives,
minimizing
damage
healthy
tissues
while
enhancing
precision.
Furthermore,
future
directions
treatment
include
exploring
innovative
targets
Wnt/β-catenin,
Notch,
TGF-β
pathways,
alongside
IGF/IGF1R
inhibition.
These
emerging
strategies
aim
address
drug
improve
patient
outcomes.
emphasizes
importance
integrating
molecular
insights
into
development,
advocating
for
a
more
personalized
approach
combat
CRC’s
complexity
heterogeneity.
Язык: Английский
Novel De Novo BRCA2 Variant in an Early-Onset Ovarian Cancer Reveals a Unique Tumor Evolution Pathway
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2295 - 2295
Опубликована: Март 5, 2025
Ovarian
cancer
(OC)
is
a
highly
heterogeneous
malignancy,
often
characterized
by
complex
genomic
alterations
that
drive
tumor
progression
and
therapy
resistance.
In
this
paper,
we
report
novel
de
novo
BRCA2
germline
variant
NM_000059.3:c.(8693_8695delinsGT)
associated
with
early-onset
OC
featured
two
regions
differential
MMR
(Mismatch
Repair)
gene
expression.
To
date,
only
six
cases
of
variants
have
been
reported,
none
which
were
high-grade
serous
OC.
The
immunohistochemical
analysis
genes
revealed
distinct
areas,
separated
clear
topographic
boundary,
the
expression
MLH1
PMS2
proteins.
Seventy-five
percent
tissue
showed
positivity,
while
remaining
25%
exhibited
complete
absence
expression,
underscoring
spatial
variability
in
within
tumor.
Integrated
comparative
profiling
identified
several
features
genetic
as
loss
heterozygosity
(LOH)
involved
genes,
along
significantly
higher
mutational
burden
area
lacked
indicating
its
further
molecular
evolution.
following
acquired:
c.6572C>T
NOTCH2,
c.1852C>T
BCL6,
c.191A>T
INHBA,
c.749C>T
CUX1,
c.898C>A
FANCG,
c.1712G>C
KDM6A.
proteomic
profiles
defects
DNA
repair
pathways,
well
significant
extracellular
matrix
(ECM).
proteins
repair,
particularly
those
Base
Excision
Repair
(BER),
highlights
critical
role
defective
mechanisms
driving
instability.
Furthermore,
ECM
components,
such
collagen
isoforms,
Fibrillin-1,
EMILIN-1,
Prolargin,
Lumican,
found
to
be
expressed
MLH1/PMS2-deficient
area,
suggesting
connection
between
deficiencies,
remodeling,
progression.
Thus,
identification
sheds
light
on
poorly
understood
interplay
deficiencies
remodeling
OC,
providing
new
insights
into
their
dual
shaping
evolution
potential
targets
for
therapeutic
strategies.
Язык: Английский
Protective effects of sesamol against cigarette smoke toxicity on the blood-brain barrier
Ildem Koru,
Belkıs Atasever-Arslan
BMC Complementary Medicine and Therapies,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 22, 2025
Cigarette
smoke
comprises
nicotine,
reactive
oxygen
species
(ROS),
and
carcinogens,
which
can
induce
oxidative
stress
inflammation,
leading
to
disruption
of
the
blood-brain
barrier.
This
study
utilized
cigarette
extract
(CSE)
in
an
vitro
model
barrier
(BBB).
Sesamol
is
a
phenolic
compound
derived
from
Sesamum
indicum
L.
Its
potential
reduce
inflammation
provide
protection
was
also
examined.
As
result
study,
it
found
that
CSE
significantly
increases
permeability
by
degrading
BBB,
whereas
protective
effect
observed
sesamol-incubated
group
within
BBB
model.
While
+
does
not
entirely
prevent
damage
induced
barrier,
exhibit
mitigating
on
damage.
In
HUVEC
cells,
significant
decrease
IL-8
levels
sesamol
groups.
T98G
were
elevated
group,
while
reduction
TNF-α
went
up
but
down
groups
cells.
Furthermore,
IL-6
increased
both
noted
cells
treatment.
The
increase
due
indicates
inflammatory
response.
It
contribute
enhanced
permeability.
result,
reduced
caused
controlling
IL-8,
IL-6,
TNF-α.
molecule
may
serve
therapeutic
role
diminishing
protecting
Язык: Английский
The Importance of Cancer Stem Cells and Their Pathways in Endometrial Cancer: A Narrative Review
Cells,
Год журнала:
2025,
Номер
14(8), С. 594 - 594
Опубликована: Апрель 14, 2025
Endometrial
cancer
is
one
of
the
most
common
malignancies
seen
in
women
developed
countries.
While
patients
early
stages
this
show
better
responses
to
surgery,
adjuvant
hormonal
therapy,
and
chemotherapy,
with
recurrence
treatment
resistance.
Researchers
have
recently
focused
on
stem
cells
(CSCs)
gynecologic
general
but
also
specifically
endometrial
cancer.
CSCs
been
investigated
because
their
resistance
conventional
therapies,
such
as
chemo-
radiotherapy,
ability
induce
progression
malignancy.
The
activation
alternative
pathways,
WNT,
PI3K,
NF-kB,
or
NOTCH,
could
be
basis
acquisition
these
abilities
CSCs.
Their
specific
markers
signaling
pathways
targets
for
In
article,
we
discuss
importance
obtaining
a
understanding
molecular
role
CSCs,
aiming
discover
more
therapeutic
approaches.
Язык: Английский
The E3 Ubiquitin Ligase Trip12 attenuates Wnt9a/Fzd9b signaling during hematopoietic stem cell development
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 25, 2024
Abstract
Wnt
signaling
is
essential
for
both
the
development
and
homeostasis
of
diverse
cellular
lineages,
including
hematopoietic
stem
cells.
Organism-wide,
signals
are
tightly
regulated,
as
overactivation
pathway
can
lead
to
tumorigenesis.
Although
numerous
ligands
Frizzled
(Fzd)
receptors
exist,
how
particular
Wnt/Fzd
pairings
established
their
regulated
poorly
understood.
We
have
previously
identified
requirements
cognate
pairing
Wnt9a
Fzd9b
early
cell
proliferation.
However,
specific
governing
activation,
but
equally
important,
molecular
mechanisms
required
turn
signal
‘off,’
unknown.
Here,
we
show
that
E3
ubiquitin
ligase
Trip12
(thyroid
hormone
receptor
interactor
12)
specifically
ubiquitinate
third
intracellular
loop
at
K437,
targeting
it
lysosomal
degradation.
In
contrast
other
ligases
described
regulate
surface
availability
multiple
Fzds
broadly,
our
data
indicate
selective
Fzd9b.
further
demonstrate
this
occurs
through
ubiquitination
K437
in
loop,
ultimately
leading
a
decrease
Wnt9a/Fzd9b
impacts
proliferation
zebrafish.
Our
results
point
driving
different
Fzd
receptors.
Determining
abundance
membrane
will
be
critical
developing
therapies
human
intervention.
One
sentence
summary
ubiquitinates
Язык: Английский
The Immune Landscape and Its Potential for Immunotherapy in Advanced Biliary Tract Cancer
Current Oncology,
Год журнала:
2024,
Номер
32(1), С. 24 - 24
Опубликована: Дек. 31, 2024
Biliary
tract
cancers
(BTC)
are
a
highly
heterogeneous
group
of
at
the
genomic,
epigenetic
and
molecular
levels.
The
vast
majority
patients
initially
present
an
advanced
(unresectable)
disease
stage
due
to
lack
symptoms
aggressive
tumour
biology.
Chemotherapy
has
been
mainstay
treatment
in
with
BTC
but
survival
outcomes
prognosis
remain
poor.
addition
immune
checkpoint
inhibitors
(ICI)
chemotherapy
have
shown
only
marginal
benefit
over
alone
complex
microenvironment
these
cancers.
This
review
appraises
our
current
understanding
landscape
BTC,
including
emerging
transcriptome-based
classifications,
highlighting
mechanisms
evasion
resistance
ICI
their
therapeutic
implications.
It
describes
shifting
paradigm
from
traditional
immunotherapy
combinations
as
well
potential
biomarkers
for
predicting
response
ICI.
Язык: Английский