Vitamin D: Beyond Traditional Roles—Insights into Its Biochemical Pathways and Physiological Impacts DOI Open Access
Vlad Mihai Voiculescu, Andreea Nelson Twakor,

Nicole Jerpelea

и другие.

Nutrients, Год журнала: 2025, Номер 17(5), С. 803 - 803

Опубликована: Фев. 26, 2025

Background: It is true that vitamin D did not earn its title as the "sunshine vitamin" for nothing. In recent years, however, there has been a shift in perception surrounding to type of hormone boasts countless bioactivities and health advantages. Historically, known take care skeletal integrity calcium-phosphorus balance body, but new scientific research displays much larger spectrum actions handled by this vitamin. Materials Methods: A systematic literature search was performed using following electronic databases: PubMed, Scopus, Web Science, Embase, Cochrane Library. Results: Many emerging ideas, especially concerning alternative hormonal pathways analogs, are uniformly challenging classic "one hormone-one receptor" hypothesis. To add more context this, receptor (VDR) previously assumed be only means through which biologically active steroid 1,25-dihydroxyvitamin D3 could impact body. Two other molecules apart from form 1,25(OH)2D3 have gained interest these reinvigorated on metabolism. These metabolites can interact with several nuclear receptors (like related orphan alpha-RORα, gamma-RORγ, aryl hydrocarbon receptor-AhR) trigger various biological responses. Conclusions: This paper thus makes case placing at forefront holistic dermatological investigating potential synergies between canonical noncanonical pathways. now plentiful opportunities manipulating understanding full actions, far beyond those minerals.

Язык: Английский

Vitamin D: Beyond Traditional Roles—Insights into Its Biochemical Pathways and Physiological Impacts DOI Open Access
Vlad Mihai Voiculescu, Andreea Nelson Twakor,

Nicole Jerpelea

и другие.

Nutrients, Год журнала: 2025, Номер 17(5), С. 803 - 803

Опубликована: Фев. 26, 2025

Background: It is true that vitamin D did not earn its title as the "sunshine vitamin" for nothing. In recent years, however, there has been a shift in perception surrounding to type of hormone boasts countless bioactivities and health advantages. Historically, known take care skeletal integrity calcium-phosphorus balance body, but new scientific research displays much larger spectrum actions handled by this vitamin. Materials Methods: A systematic literature search was performed using following electronic databases: PubMed, Scopus, Web Science, Embase, Cochrane Library. Results: Many emerging ideas, especially concerning alternative hormonal pathways analogs, are uniformly challenging classic "one hormone-one receptor" hypothesis. To add more context this, receptor (VDR) previously assumed be only means through which biologically active steroid 1,25-dihydroxyvitamin D3 could impact body. Two other molecules apart from form 1,25(OH)2D3 have gained interest these reinvigorated on metabolism. These metabolites can interact with several nuclear receptors (like related orphan alpha-RORα, gamma-RORγ, aryl hydrocarbon receptor-AhR) trigger various biological responses. Conclusions: This paper thus makes case placing at forefront holistic dermatological investigating potential synergies between canonical noncanonical pathways. now plentiful opportunities manipulating understanding full actions, far beyond those minerals.

Язык: Английский

Процитировано

0