Identification of an Immune-Related Gene Signature for Prognostic Prediction in Glioblastoma: Insights from Integrated Bulk and Single-Cell RNA Sequencing DOI Open Access
Jianan Chen, Qiong Wu, Anders Berglund

и другие.

Cancers, Год журнала: 2025, Номер 17(11), С. 1799 - 1799

Опубликована: Май 28, 2025

Background: Glioblastoma is a highly malignant brain tumor with limited treatment options and poor prognosis, largely driven by its complex immune microenvironment. This study aimed to identify characterize an immune-related gene signature associated prognosis regulation in glioblastoma. Methods: We performed integrative analyses using bulk single-cell RNA sequencing data prognostically significant genes. A five-gene (THEMIS2, SIGLEC9, CSTA, LILRB3, MS4A6A) was derived expression patterns were analyzed association cell infiltration macrophage subtypes. Functional enrichment pathway conducted, followed drug sensitivity profiling explore potential therapeutic implications. Results: The significantly worse survival outcomes increased infiltration. revealed involvement key pathways, including antigen presentation, cytokine signaling, activation. Single-cell demonstrated high of the tumor-associated macrophages, particularly immune-suppressive proliferation-associated proliferation TAMs suggests role promoting angiogenesis growth. Drug analysis distinct vulnerabilities between high- low-risk groups based on expression. Conclusions: Macrophage-Associated Prognostic Signature (MAPS) provides new insights into glioblastoma immunobiology identifies biomarkers targets. It may serve as valuable tool guide personalized immunotherapy-based strategies for patients.

Язык: Английский

Histone lactylation regulates PRKN-Mediated mitophagy to promote M2 Macrophage polarization in bladder cancer DOI
Xiaolin Deng,

Yuan Huang,

Jinge Zhang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114119 - 114119

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
Role of liposomes in chemoimmunotherapy of Breast cancer DOI

Fatemeh Attarian,

Ghazaleh Hatamian,

Shamim Nosrati

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43

Опубликована: Фев. 19, 2025

In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.

Язык: Английский

Процитировано

1
Lactobacillus plantarum-Derived Inorganic Polyphosphate Regulates Immune Function via Inhibiting M1 Polarization and Resisting Oxidative Stress in Macrophages DOI Creative Commons
Shuzhen Li,

Aijuan Zheng,

Zhimin Chen

и другие.

Antioxidants, Год журнала: 2025, Номер 14(4), С. 428 - 428

Опубликована: Апрель 1, 2025

Inorganic polyphosphate (PolyP) is a high-molecular-weight polymer that plays multiple roles in regulating immune responses. However, the specific anti-inflammatory mechanisms of bacteria-derived PolyP are unclear. In present study, was extracted from Lactobacillus plantarum (L. plantarum), and chain length estimated to be approximately 250 Pi residues. The regulatory functions were investigated using lipopolysaccharide (LPS)-induced RAW264.7 cell oxidative stress model, dexamethasone used as positive control. result revealed both protective against by inhibiting macrophage M1 polarization production several markers, such nitric oxide (NO), reactive oxygen species (ROS), inducible synthase (iNOS), cyclooxygenase (COX)-2. addition, suppressed inflammation progression cytokines, interleukin (IL)-1β, interferon (INF)-γ, tumor necrosis factor (TNF)-α, IL-6, inhibited expressions inhibitory κB kinase (IKK) α, IKKβ, extracellular regulated protein kinases 2 (ERK2). Conclusively, derived L. has ability protect cells damage macrophages. These findings provide insights into function offer support for potential application immune-related diseases.

Язык: Английский

Процитировано

0
Combination of radiotherapy and ICIs in advanced hepatocellular carcinoma: A systematic review of current evidence and future prospects (Review) DOI Open Access
Cheng Ma,

Xinlin Yu,

Xialin Zhang

и другие.

Oncology Letters, Год журнала: 2025, Номер 30(1), С. 1 - 15

Опубликована: Май 14, 2025

Hepatocellular carcinoma (HCC) is a global health concern because of its rising prevalence and high fatality rates. Conventional treatments for advanced HCC (aHCC) have limited success, emphasizing the need novel treatment options. Radiotherapy (RT) treatments, such as stereotactic body radiation proton therapy, improve local tumor management via precision targeting. Moreover, immune checkpoint inhibitors (ICIs) that target programmed cell death protein 1(PD-1)/PD ligand 1 (PD-L1) cytotoxic T lymphocyte associated 4 (CTLA-4) pathways promise systemic antitumor effectiveness. The combination RT ICIs takes advantage their complementary mechanisms: kills immunogenic cells controls microenvironment to increase antigen presentation, whereas enhance maintain responses. This enhances regression response in aHCC, improving rate progression-free survival with manageable safety. present review aimed summarize rationale combining + patients aHCC clinical outcomes, well ways this technique. these models promising technique outcomes warrants further investigation.

Язык: Английский

Процитировано

0
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy DOI Creative Commons
Abdullah F. U. H. Saeed

Cells, Год журнала: 2025, Номер 14(10), С. 741 - 741

Опубликована: Май 19, 2025

Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research

Язык: Английский

Процитировано

0
Identification of an Immune-Related Gene Signature for Prognostic Prediction in Glioblastoma: Insights from Integrated Bulk and Single-Cell RNA Sequencing DOI Open Access
Jianan Chen, Qiong Wu, Anders Berglund

и другие.

Cancers, Год журнала: 2025, Номер 17(11), С. 1799 - 1799

Опубликована: Май 28, 2025

Background: Glioblastoma is a highly malignant brain tumor with limited treatment options and poor prognosis, largely driven by its complex immune microenvironment. This study aimed to identify characterize an immune-related gene signature associated prognosis regulation in glioblastoma. Methods: We performed integrative analyses using bulk single-cell RNA sequencing data prognostically significant genes. A five-gene (THEMIS2, SIGLEC9, CSTA, LILRB3, MS4A6A) was derived expression patterns were analyzed association cell infiltration macrophage subtypes. Functional enrichment pathway conducted, followed drug sensitivity profiling explore potential therapeutic implications. Results: The significantly worse survival outcomes increased infiltration. revealed involvement key pathways, including antigen presentation, cytokine signaling, activation. Single-cell demonstrated high of the tumor-associated macrophages, particularly immune-suppressive proliferation-associated proliferation TAMs suggests role promoting angiogenesis growth. Drug analysis distinct vulnerabilities between high- low-risk groups based on expression. Conclusions: Macrophage-Associated Prognostic Signature (MAPS) provides new insights into glioblastoma immunobiology identifies biomarkers targets. It may serve as valuable tool guide personalized immunotherapy-based strategies for patients.

Язык: Английский

Процитировано

0