International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 555 - 555

Опубликована: Янв. 10, 2025

Jun/JUN is a basic leucine zipper (bZIP) protein and prototypic member of the activator protein-1 (AP-1) family transcription factors that can act as homo- or heterodimers, interact with DNA elements co-factors, regulate gene transcription. Jun expressed by both immune inflammatory cells. traditionally seen an oncoprotein regulates processes involved in transformation oncogenesis human tumours. This article examines traditional view plays permissive role cancer development progression, whilst exploring emerging evidence supporting Jun’s potential to prevent cell exhaustion promote anti-tumour efficacy.

Язык: Английский