Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery
M.D. HEBAT-ALLAH G. RASHED SHAABAN R. HELAL,
Amna Ibrahim,
Ahmad Beddor
и другие.
Neurochemical Research,
Год журнала:
2025,
Номер
50(1)
Опубликована: Янв. 3, 2025
Abstract
Huntington’s
disease
(HD)
is
a
progressive
neurodegenerative
resulting
from
mutation
in
the
huntingtin
(HTT)
gene
and
characterized
by
motor
dysfunction,
cognitive
decline,
psychiatric
disturbances.
Currently,
no
disease-modifying
treatments
are
available.
Recent
research
has
developed
therapeutic
agents
that
may
have
potential
to
directly
target
pathology,
such
as
silencing
or
clearing
mutant
protein.
However,
these
limited
their
inability
cross
blood-brain
barrier
(BBB),
preventing
optimal
effects.
Although
various
techniques
been
explored
overcome
BBB,
focused
ultrasound
(FUS)
emerged
promising
non-invasive
modality
offering
for
targeted
intervention
diseases,
including
HD.
Preclinical
studies
demonstrated
safety
efficacy
of
FUS
delivering
agents,
siRNAs
AAV
vector-based
therapy,
significant
reductions
HTT
expression
improvements
function
HD
mouse
models.
Furthermore,
profile
FUS-induced
BBB
opening
established
clinical
trials
on
human
patients
diseases
other
than
HD,
showing
adverse
effects
brain
structure
function.
This
review
provides
comprehensive
overview
current
state
connects
existing
evidence
with
its
promise
establishing
therapies
Graphical
Язык: Английский
Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors
Biomaterials,
Год журнала:
2025,
Номер
319, С. 123180 - 123180
Опубликована: Фев. 13, 2025
Язык: Английский
Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 84 - 84
Опубликована: Янв. 1, 2025
Despite
the
massive
efforts
of
modern
medicine
to
stop
evolution
Alzheimer’s
disease
(AD),
it
affects
an
increasing
number
people,
changing
individual
lives
and
imposing
itself
as
a
burden
on
families
health
systems.
Considering
that
vast
majority
conventional
drug
therapies
did
not
lead
expected
results,
this
review
will
discuss
newly
developing
alternative
in
effort
or
slow
AD.
Focused
Ultrasound
(FUS)
its
derived
Transcranial
Pulse
Stimulation
(TPS)
are
non-invasive
therapeutic
approaches.
Singly
applied
technique
change
permeability
blood–brain–barrier
(BBB),
FUS
TPS
have
demonstrated
benefits
use
treating
AD
animal
human
studies.
Adipose-derived
stem
Cells
(ADSCs),
gene
therapy,
many
other
methods
(diet,
sleep
pattern,
physical
exercise,
nanoparticle
delivery)
also
new
potential
treatments
since
multimodal
approaches
represent
trend
disorder
research
therapies.
Язык: Английский
Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies
Pharmaceuticals,
Год журнала:
2025,
Номер
18(1), С. 104 - 104
Опубликована: Янв. 15, 2025
Cytokine-mediated
inflammation
is
increasingly
recognized
for
playing
a
vital
role
in
the
pathophysiology
of
wide
range
brain
disorders,
including
neurodegenerative,
psychiatric,
and
neurodevelopmental
problems.
Pro-inflammatory
cytokines
such
as
interleukin-1
(IL-1),
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6)
cause
neuroinflammation,
alter
function,
accelerate
disease
development.
Despite
progress
understanding
these
pathways,
effective
medicines
targeting
are
still
limited.
Traditional
anti-inflammatory
immunomodulatory
drugs
peripheral
inflammatory
illnesses.
Still,
they
face
substantial
hurdles
when
applied
to
central
nervous
system
(CNS),
blood-brain
barrier
(BBB)
unwanted
systemic
effects.
This
review
highlights
developing
treatment
techniques
modifying
cytokine-driven
focusing
on
advances
that
selectively
target
critical
involved
pathology.
Novel
approaches,
cytokine-specific
inhibitors,
antibody-based
therapeutics,
gene-
RNA-based
interventions,
sophisticated
drug
delivery
systems
like
nanoparticles,
show
promise
with
respect
lowering
neuroinflammation
greater
specificity
safety.
Furthermore,
developments
biomarker
discoveries
neuroimaging
improving
our
ability
monitor
responses,
allowing
more
accurate
personalized
regimens.
Preclinical
clinical
trial
data
demonstrate
therapeutic
potential
tailored
techniques.
However,
significant
challenges
remain,
across
BBB
reducing
off-target
As
research
advances,
creation
personalized,
cytokine-centered
therapeutics
has
therapy
landscape
illnesses,
giving
patients
hope
better
results
higher
quality
life.
Язык: Английский
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies
Neurochemical Research,
Год журнала:
2025,
Номер
50(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13614 - 13614
Опубликована: Дек. 19, 2024
Neuroimmunology
is
reshaping
the
understanding
of
central
nervous
system
(CNS),
revealing
it
as
an
active
immune
organ
rather
than
isolated
structure.
This
review
delves
into
unprecedented
discoveries
transforming
field,
including
emerging
roles
microglia,
astrocytes,
and
blood–brain
barrier
(BBB)
in
orchestrating
neuroimmune
dynamics.
Highlighting
their
dual
both
repair
disease
progression,
we
uncover
how
these
elements
contribute
to
intricate
pathophysiology
neurodegenerative
diseases,
cerebrovascular
conditions,
CNS
tumors.
Novel
insights
microglial
priming,
astrocytic
cytokine
networks,
meningeal
lymphatics
challenge
conventional
paradigms
privilege,
offering
fresh
perspectives
on
mechanisms.
work
introduces
groundbreaking
therapeutic
innovations,
from
precision
immunotherapies
controlled
modulation
BBB
using
nanotechnology
focused
ultrasound.
Moreover,
explore
fusion
with
neuromodulatory
technologies,
underscoring
new
frontiers
for
personalized
medicine
previously
intractable
diseases.
By
synthesizing
advancements,
propose
a
transformative
framework
that
integrates
cutting-edge
research
clinical
translation,
charting
bold
path
toward
redefining
management
era
neuroimmunology.
Язык: Английский