Advances in nano-delivery systems based on diagnosis and theranostics strategy for atherosclerosis DOI

Xi Yang,

Jianhua Hu, Qing Gao

и другие.

Journal of drug targeting, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Ноя. 27, 2024

Atherosclerosis (AS) is a chronic systemic inflammatory disease, where early diagnosis and theranostics strategy for AS are crucial improving outcomes. However, conventional diagnostic techniques limited in identifying lesions, failing to stop the progression of time. Nano-delivery systems have shown significant potential treatment, offering distinct advantages plaque identification enhancing drugs concentration at lesion sites, thereby advancing new-generation strategy. This review discusses application nano-delivery based on imaging technology diagnosis, we further explore recent advancements combining different technologies with emerging In addition, also discuss challenges faced by clinical translation, such as nanoparticle targeting efficiency, cytotoxicity long-term accumulation, immune clearance inaccurate disease modelling. Finally, provide prospects therapeutic strategies.

Язык: Английский

The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells DOI Creative Commons
Yasin Ahmadi, Sakhavat Abolhasani,

Yavar Rostami

и другие.

Cell Division, Год журнала: 2025, Номер 20(1)

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

2
Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives DOI Creative Commons
Menghua Liu, Rumeng Chen,

Zhiwei Zheng

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 14, 2025

Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular cellular within inflammatory microenvironment atherosclerosis, hypertension diabetic cardiomyopathy. In oxidized low-density lipoprotein (ox-LDL) pro-inflammatory cytokines such as Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing foam cell formation arterial wall thickening. Hypertension involves activation renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction local mediated by T cells. cardiomyopathy, high-glucose environment leads accumulation advanced glycation end products (AGEs), activating Receptor for Advanced Glycation Endproducts (RAGE) triggering responses that further damage cardiac microvascular function. summary, different types metabolic cardiovascular diverse; understanding these deeply will aid developing more effective individualized treatment strategies.

Язык: Английский

Процитировано

1
Research Progress and Clinical Translation Potential of Coronary Atherosclerosis Diagnostic Markers from a Genomic Perspective DOI Open Access
Hanxiang Liu, Yuchen Zhang,

Yueyan Zhao

и другие.

Genes, Год журнала: 2025, Номер 16(1), С. 98 - 98

Опубликована: Янв. 18, 2025

Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to wall thickening lumen narrowing. As the primary cause of coronary heart disease acute syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD’s polygenic multifactorial nature, providing molecular insights for early diagnosis risk assessment. This review analyzes recent advances in CAD-related markers evaluates their diagnostic potential, focusing on applications stratification within precision medicine. Methods: We conducted a systematic genomic from PubMed Web Science databases, analyzing findings genome-wide association (GWASs), gene sequencing, transcriptomics, epigenomics research. Results: GWASs sequencing identified key variations associated with CAD, including JCAD/KIAA1462, GUCY1A3, PCSK9, SORT1, which regulate metabolism, vascular function. Transcriptomic epigenomic analyses revealed disease-specific expression patterns, DNA methylation signatures, regulatory non-coding RNAs (miRNAs lncRNAs), new approaches detection. Conclusions: While marker research has advanced significantly, clinical implementation faces challenges dynamics, lack standardization, integration conventional diagnostics. Future should prioritize developing standardized guidelines, conducting large-scale prospective studies, enhancing multi-omics data advance diagnostics ultimately improving patient outcomes through

Язык: Английский

Процитировано

0
In Vitro Study of Vitamin D Effects on Immune, Endothelial, and Vascular Smooth Muscle Cells in Chronic Kidney Disease DOI Open Access

Kajal Kamboj,

Vivek Kumar, Ashok Kumar Yadav

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 3967 - 3967

Опубликована: Апрель 23, 2025

Vitamin D has been shown to improve immunity as well vascular function. We investigated the effect of cholecalciferol on T-cell phenotype in cultured peripheral blood mononuclear cells (PBMCs) from twenty vitamin D-deficient, non-diabetic chronic kidney disease (CKD) subjects. also studied effects endothelial and function markers human aortic (HAECs) smooth muscle (HASMCs), respectively. nitric oxide synthase (eNOS), mitogen-activated protein kinase 38 (p38 Map kinase), B (Akt), nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) HAECs α-smooth actin (α-SMA), calponin (SM-Calponin), myosin heavy chain (SM-MHC), calcium-sensing receptor (CaSR) HASMCs. receptors (VDRs) CYP27B1 were both cell types. In PBMCs isolated CKD subjects, percentage T helper 1(TH1) significantly decreased while that 2 (TH2) increased after treatment. No significant change intracellular surface 17 (TH17) regulatory (Treg) was observed. vitro treatment HASMCs with led favorable alterations mRNA expression cells, i.e., α-SMA, SM-Calponin, SM-MHC. Regarding markers, encoding eNOS, p38 kinase, NADPH oxidase, VDR, changed. Finally, levels following proteins notably altered: (Akt) (in HAECs); SM-MHC SM-Calponin HASMCs). a population, decreasing TH1 increasing TH2 percentage, along beneficial HAECs’ markers. This study provides evidence can influence immune CKD.

Язык: Английский

Процитировано

0
Dedifferentiation of vascular smooth muscle cells upon vessel injury DOI
Chaoyue Zhao, Jian Shen,

Yunrui Lu

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 144, С. 113691 - 113691

Опубликована: Ноя. 25, 2024

Язык: Английский

Процитировано

0
Advances in nano-delivery systems based on diagnosis and theranostics strategy for atherosclerosis DOI

Xi Yang,

Jianhua Hu, Qing Gao

и другие.

Journal of drug targeting, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Ноя. 27, 2024

Atherosclerosis (AS) is a chronic systemic inflammatory disease, where early diagnosis and theranostics strategy for AS are crucial improving outcomes. However, conventional diagnostic techniques limited in identifying lesions, failing to stop the progression of time. Nano-delivery systems have shown significant potential treatment, offering distinct advantages plaque identification enhancing drugs concentration at lesion sites, thereby advancing new-generation strategy. This review discusses application nano-delivery based on imaging technology diagnosis, we further explore recent advancements combining different technologies with emerging In addition, also discuss challenges faced by clinical translation, such as nanoparticle targeting efficiency, cytotoxicity long-term accumulation, immune clearance inaccurate disease modelling. Finally, provide prospects therapeutic strategies.

Язык: Английский

Процитировано

0