Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 31, 2024
In
the
present
study,
extracellular
cell-free
filtrate
(CFF)
of
fungal
Fusarium
oxysporum
f.
sp.
cucumerinum
(FOC)
species,
was
utilized
to
biosynthesize
zinc
oxide
/zinc
sulfide
(ZnO/ZnS)
nanocomposite.
This
achieved
by
mixing
metal
salt
with
CFF
for
96
h
at
a
temperature
27
±
1.0
°C
and
pH
6.5.
Several
analytical
techniques,
such
as
XRD,
TEM,
UV-Vis,
FTIR,
DLS,
zeta
potential
studies,
have
confirmed
synthesis
NPs.
Fungal
enzymes
metabolites
stabilized
produced
NPs,
according
FTIR.
The
nanocomposite
particle
diameter
(15-80
nm)
estimated
using
HR-TEM
imaging.
DLS
XRD
measurements
verified
those
findings.
zone
inhibition
MRSA
35
0.21
mm,
while
B.
subtilis
measured
33
0.32
mm
against
For
E.
coli
S.
typhi
bacterial
isolates,
it
25
0.19
32
0.36
respectively.
determined
MIC
value
5,000
µg/mL
500
µg/mL.
ZnO/ZnS
has
dose-dependent
cytotoxic
effect
on
breast
cancer
cells,
an
IC
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 860 - 860
Опубликована: Янв. 20, 2025
Soil
salinization
poses
a
significant
challenge
to
global
agriculture,
particularly
in
arid
and
semi-arid
regions
like
Xinjiang.
Kalidium
schrenkianum,
halophytic
plant
adapted
saline-alkaline
conditions,
harbors
endophytic
microorganisms
with
potential
growth-promoting
properties.
In
this
study,
177
bacterial
strains
were
isolated
from
K.
11
key
identified
through
functional
screening
based
on
salt
tolerance,
nutrient
solubilization,
traits.
Synthetic
microbial
communities
(SMCs)
then
constructed
using
these
optimized
enhance
wheat
growth
under
stress.
The
SMCs
significantly
improved
seed
germination,
root
length,
seedling
vigor
both
spring
winter
hydroponic
pot
experiments.
Furthermore,
the
enhanced
activities
of
antioxidant
enzymes,
including
superoxide
dismutase
(SOD),
peroxidase
(POD),
catalase
(CAT),
levels
malondialdehyde
(MDA)
proline
(PRO).
They
also
reduced
oxidative
stress
chlorophyll
content
seedlings.
These
results
demonstrate
consortia
derived
extreme
environments
as
eco-friendly
biofertilizers
for
improving
crop
performance
saline
soils,
offering
sustainable
alternative
chemical
fertilizers
contributing
agricultural
resilience
productivity.
International Research Journal of Multidisciplinary Technovation,
Год журнала:
2025,
Номер
unknown, С. 165 - 187
Опубликована: Янв. 29, 2025
A
serious
worldwide
health
emergency
has
been
brought
on
by
the
growth
of
multidrug-resistant
(MDR)
microorganisms,
which
are
difficult
to
treat
with
traditional
antimicrobial
drugs.
This
emphasises
how
urgently
novel
therapeutic
approaches
needed
combat
drug
resistance
(ABR).
To
increase
efficacy
treatment
for
resistant
one
such
tactic,
known
as
nAbts
mixes
medications
nanoparticles.
work
looks
at
development
nano-based
systems
ABR,
specifically
urinary
tract
infections
pathogenic
microbes.
Important
results
show
that
more
effective
than
conventional
antibiotics.
For
instance,
in
vitro
research
showed
silver
nanoparticle-based
decreased
bacterial
ciprofloxacin-resistant
Escherichia
coli
strains
98%,
opposed
30–40%
reduction
seen
ciprofloxacin
alone.
The
capacity
nanoparticles
break
down
cell
walls,
boost
medication
penetration,
and
enable
targeted
delivery—thereby
circumventing
mechanisms—is
responsible
this
notable
activity.
With
their
walls
promote
intracellular
accumulation,
hold
enormous
promise
defeating
providing
a
major
breakthrough
management
illnesses.
offer
safer,
focused,
successful
alternatives
ABR
is
highlighted
publication.
Microbial Cell Factories,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 21, 2025
Sustainable
biosynthesis
of
metal
oxide
nanoparticles
using
an
eco-friendly
approach
is
a
growing
research
area
owing
to
their
promising
environmental
and
biomedical
applications.
This
work
aims
biosynthesize
characterize
magnesium
(MgONPS@Aj)
for
possible
application
in
dye
biosorption
antibacterial
activity.
For
the
first
time,
MgONPS@Aj
was
successfully
synthesized
by
harnessing
exometabolites
Aspergillus
japonicus.
Various
parameters
were
statistically
optimized
maximize
production
Plackett
Burman's
design
central
composite
design.
The
analysis
variance
(ANOVA)
revealed
that
pH
most
significant
variable,
affecting
bioproduction
process
followed
biomass
quantity
Mg2+
precursor
concentration.
suggested
model
(quadratic)
greatly
acceptable
due
nonsignificant
lack
fit
(15.10),
P-value
(0.001).
characterized
X-ray
powder
diffraction,
Fourier-transform
infrared
(FTIR)
spectroscopy,
transmission
electron
microscope
(TEM),
Scanning
microscopy.
A
high
capacity
(204.08
mg/g)
reactive
black
5
achieved
within
40
min
mg
biosorbent
dose
(MgONPS@Aj),
100
mg/l
initial
concentration,
6.0.
pseudo-second-order
(R2
0.9842)
Langmuir
isotherm
0.9422)
models
with
dimensionless
separation
factor
(RL)
8
×
104,
hinting
favorable
effective
molecules.
81.97
mg/g
after
five
successive
cycles
hints
nanomaterial
suitable
several
time
utilization.
Biogenic
displayed
dramatic
concentration-dependent
activity
largest
inhibition
zones
P.
aeruginosa
(24.1
±
0.8
mm,
MIC:
3.125
µg/ml),
E.
coli
(22.3
0.7
MIC
6.25),
B.
subtilis
(14.7
0.4
12.5
µg/ml)
S.
aureus
(19.2
0.6
6.25
µg/ml).
further
interpreted
molecular
simulation
analysis.
lowest
binding
affinity
determined
between
target
bacterial
proteins
(chloramphenicol
acetyltransferase
coli,
MurE).
ligand
can
bind
active
site's
residues
(Tyr172
SER224),
indicating
mechanism.
study
recommends
as
eco-friendly,
reusable
alternative
traditional
anionic
sorbents
uniquely
candidate
antimicrobial
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Март 20, 2025
The
isoquinoline
alkaloid
berberine,
a
bioactive
compound
derived
from
various
plants,
has
demonstrated
extensive
therapeutic
potential.
However,
its
clinical
application
is
hindered
by
poor
water
solubility,
low
bioavailability,
rapid
metabolism,
and
insufficient
targeting.
Metal-based
nanoplatforms
offer
promising
solutions,
enhancing
drug
stability,
controlled
release,
targeted
delivery.
This
review
comprehensively
explores
the
synthesis,
physicochemical
properties,
biomedical
applications
of
metal-based
nanocarriers,
including
gold,
silver,
iron
oxide,
zinc
selenium,
magnetic
nanoparticles,
for
berberine
delivery
to
improve
berberine's
efficacy.
Recent
advancements
in
nanocarrier
systems
have
significantly
improved
cellular
uptake,
extending
circulation
time,
enabling
site-specific
encounter
several
limitations
potential
toxicity,
limited
large-scale
productions,
regulatory
constraints.
Addressing
these
necessitates
studies
on
biocompatibility,
long-term
safety,
translation.
By
summarizing
latest
innovations
perspectives,
this
aims
guide
future
research
toward
optimizing
berberine-based
nanomedicine
Bulletin of the National Research Centre/Bulletin of the National Research Center,
Год журнала:
2025,
Номер
49(1)
Опубликована: Апрель 9, 2025
Abstract
Background
The
synthesis
of
nanomaterials
has
traditionally
relied
on
methods
that
pose
significant
environmental
risks
due
to
high-energy
demands,
hazardous
chemicals,
and
waste
generation.
For
instance,
conventional
techniques
such
as
chemical
vapor
deposition
the
sol–gel
process
are
known
for
their
consumption
production
toxic
by-products.
This
context
emphasizes
importance
sustainability
in
nanomaterial
synthesis,
leading
a
shift
toward
more
eco-friendly
integrate
principles
green
chemistry
lessen
influence
environment.
transition
addresses
harmful
effects
associated
with
traditional
approaches
promotes
use
renewable
resources,
biomass
agricultural
waste,
production.
Main
body
review
focuses
sustainable
utilize
biomass,
natural
extracts.
These
reduce
energy
consumption,
limit
generation,
enhance
recyclability,
supporting
nanocircular
economy.
Various
strategies,
including
hydrothermal
solvents,
examined
effectiveness
producing
desirable
properties.
also
highlights
broad
applications
these
catalysis,
sensing,
biomedical
fields,
storage.
Despite
considerable
advancements,
field
faces
ongoing
challenges
related
scalability,
comprehensive
impact
assessments,
need
performance
optimization.
Conclusion
presents
opportunities
advancing
technologies
reducing
footprint
While
remain,
continued
research
innovation
promise
further
progress
scalable
efficient
methods,
driving
development
an
environmentally
conscious
approach
synthesis.
Frontiers in Nanotechnology,
Год журнала:
2025,
Номер
7
Опубликована: Апрель 14, 2025
Multimetallic
nanoparticles
(MMNPs)
produced
by
fungus-mediated
synthesis
have
attracted
a
lot
of
interest
as
an
environmentally
friendly
and
sustainable
nanotechnology
method.
Fungi
are
effective
bio-factories
that
create
complex
with
special
qualities
using
their
metabolic
enzymatic
capabilities.
When
compared
to
monometallic
counterparts,
MMNPs—which
composed
combinations
two
or
more
metals—offer
synergistic
benefits
such
increased
catalytic
activity,
higher
stability,
superior
biocompatibility.
In
addition
highlighting
the
structural
diversity
MMNPs,
core-shell,
alloy,
Janus
configurations,
this
review
investigates
mechanisms
underpinning
fungal-mediated
synthesis,
including
reduction
stabilisation
pathways.
Additionally
covered
characterisation
methods
for
examining
functionality,
morphology,
composition.
The
potential
applications
MMNPs
synthesized
fungi
in
biomedicine,
environmental
remediation,
biosensing,
catalysis
highlighted
article.
This
green
method,
which
makes
use
natural
fungus
multimetallic
systems,
responds
increasing
need
nanomaterials
opens
door
novel
uses
both
scientific
industrial
fields.
