Devices to overcome the buccal mucosal barrier to administer Therapeutic Peptides

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115572 - 115572

Опубликована: Март 1, 2025

Peptide therapeutics are important in healthcare owing to their high target specificity, therapeutic efficacy, and relatively low side effect profile. Injections of these agents have improved thetreatment chronic diseases including autoimmune, metabolic disorders, cancer. However, administration via injections can prove a barrier patient acceptability treatments. While oral delivery molecules is preferable, peptide formulations associated with limited bioavailability due degradation the intestine epithelial permeability. Buccal peptides potential alternative formulations. Similar route, buccal route promote better adherence dosing regimens, along added advantages not requiring restriction on food or drink consumption before after administration, as well avoidance liver first-pass metabolism. like oral, effective absorption still challenging permeability barrier. We present multidisciplinary approach understanding physiological macromolecule permeation discuss how engineered devices may overcome it. Selected examples facilitate fast efficient through multiple mechanisms physical disruption epithelia, convection-based mass transfer, combination physicochemical strategies. Importantly, minimally invasive be self-applied maintenance exposure. analysed critical attributes that required forthe clinical translation devices. These include performance-driven device development, manufacturing features, acceptability, commercial viability.

Язык: Английский

Enhancing vaccine stability in transdermal microneedle platforms

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

Research on the Graded Classification Management System Based on Multi-Dimensional Patent Value Evaluation

Опубликована: Дек. 27, 2024

Язык: Английский