NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue

Biomedicines, Год журнала: 2025, Номер 13(1), С. 224 - 224

Опубликована: Янв. 17, 2025

Background/Objectives: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, impaired contractility. Cellular mechanisms such as senescence, telomere shortening, DNA damage contribute to these processes. Nuclear factor kappa B (NF-κB) has been implicated mediating cellular responses aging tissues, increased NF-κB expression observed hearts of rodents. Therefore, suspected play an important regulatory role molecular processes occurring heart during aging. This study investigates vivo aging-related cardiac alterations, focusing on senescence events. Methods: Young old wild-type (WT) transgenic male mice cardiomyocyte-specific suppression (3M) were used assess function, morphology, markers, lipofuscin deposition, damage, apoptosis. Results: Kaplan–Meier analysis revealed reduced survival 3M compared WT. Echocardiography showed evidence eccentric both diastolic systolic dysfunction mice. Both aged WT exhibited more pronounced hypertrophic cardiomyocytes from Additionally, senescence-associated β-galactosidase activity, p21 protein expression, (marked by phosphorylated H2A.X) elevated young Conclusions: The leads remodeling, dysfunction, process. These findings suggest that plays a critical aging, influencing pathways. implications for development therapeutic strategies aimed at mitigating age-related cardiovascular diseases.

Язык: Английский

Melissa officinalis extract nanoemulsion, Caffeic acid and Quercetin as a novel inducer for investigating neural differentiation of human Wharton's jelly mesenchymal stem cells

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102815 - 102815

Опубликована: Март 7, 2025

Язык: Английский