Austroasiatic
(AA)-speaking
populations
in
northern
Thailand
are
of
significant
interest
due
to
their
status
as
indigenous
descendants
and
location
at
the
crossroads
AA
prehistoric
distribution
across
Southern
China,
Indian
Subcontinent,
Mainland
Southeast
Asia.
However,
complexity
ethnic
identification
can
result
inaccuracies
regarding
origin
migration
history
these
populations.
To
address
this,
we
have
conducted
a
genome-wide
SNP
analysis
89
individuals
from
two
Lavue
three
Lwa-endonym
We
then
combined
our
outcomes
with
previously
published
data
elucidate
genetic
diversity
clustering
groups
Thailand.
Molecular Biology and Evolution,
Год журнала:
2024,
Номер
41(7)
Опубликована: Июнь 17, 2024
Abstract
Large-scale
genomic
projects
and
ancient
DNA
innovations
have
ushered
in
a
new
paradigm
for
exploring
human
evolutionary
history.
However,
the
genetic
legacy
of
spatiotemporally
diverse
Eurasians
within
Chinese
paternal
lineages
remains
unresolved.
Here,
we
report
an
integrated
Y-chromosome
database
encompassing
15,563
individuals
from
both
modern
Eurasians,
including
919
newly
reported
individuals,
to
investigate
diversity.
The
high-resolution,
time-stamped
phylogeny
reveals
multiple
diversification
events
extensive
expansions
early
middle
Neolithic.
We
identify
four
major
population
movements,
each
associated
with
technological
that
shaped
landscape.
First,
expansion
East
Asians
millet
farmers
Yellow
River
Basin
predominantly
carrying
O2/D
subclades
significantly
influenced
formation
Sino-Tibetan
people
facilitated
permanent
settlement
Tibetan
Plateau.
Second,
dispersal
rice
Yangtze
Valley
O1
certain
O2
sublineages
reshapes
makeup
southern
Han
Chinese,
as
well
Tai-Kadai,
Austronesian,
Hmong-Mien,
Austroasiatic
people.
Third,
Neolithic
Siberian
Q/C
originated
proliferated
among
hunter-gatherers
on
Mongolian
Plateau
Amur
Basin,
leaving
significant
imprint
gene
pools
northern
China.
Fourth,
J/G/R
derived
western
Eurasia,
which
were
initially
spread
by
Yamnaya-related
steppe
pastoralists,
maintain
their
presence
primarily
northwestern
Overall,
our
research
provides
comprehensive
evidence
elucidating
impact
interactions
culturally
distinct
patterns
diversity
populations.
hLife,
Год журнала:
2024,
Номер
2(11), С. 554 - 562
Опубликована: Июнь 26, 2024
Central
Asia,
a
crucible
of
prehistoric
and
historical
Trans-Eurasian
interactions,
has
been
pivotal
in
shaping
cultural
exchanges,
population
dynamics,
genetic
admixture.
Recent
insights
from
ancient
DNA
studies
have
shed
light
on
the
extensive
turnover
within
this
region,
encompassing
spectrum
groups
Paleolithic
hunter-gatherers
to
Holocene
herders
nomadic
pastoralist
empires
times.
The
genomic
analysis
pathogens
across
Eurasian
steppe
further
deepened
our
understanding
pathogen
origins,
clonal
expansions,
intricate
processes
host-pathogen
coevolution
relation
varying
exposures
their
spread.
We
consolidate
latest
findings
pertaining
human
genomes
elucidating
profound
influence
tapestry
contemporary
Asians.
A
notable
gap
current
databases
for
Asia
is
underscored,
particularly
scope
genomics-driven
precision
medicine.
stress
urgent
need
development
extensive,
region-specific
resources
that
hold
promise
revealing
blueprints
underlying
traits
diseases,
refining
polygenic
scoring
models
predictive
medicine,
bolstering
research
endeavors
Asia.
Frontiers in Ecology and Evolution,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 3, 2025
Biogeographical
ancestry
inference
offers
valuable
clues
for
forensic
cold
cases,
but
limited
information
is
typically
obtained
from
substructured
populations
within
continental
East
Asian
and
Southeast
groups.
This
study
presents
an
integrative
genomic
dataset
of
3,461
individuals
Asia
to
elucidate
the
fine-scale
population
substructure
its
role
in
precision
medicine.
Six
nested
panels
were
developed
with
increasing
ancestry-informative
marker
(AIM)
density
(ranging
50
2,000
SNPs)
distinguish
fine
genetic
differences
between
six
language
groups
Sino-Tibetan
family.
We
found
that
2000
AIM
panel
exhibited
differentiation
efficiency
PCA
comparable
all
loci.
Additionally,
we
constructed
a
classification
machine
learning
model
average
prediction
accuracy
84%,
highlighting
critical
geographical
improving
accuracy.
Furthermore,
validated
deep
method
Locator
predicting
coordinates
solely
based
on
information.
work
highlights
power
integrating
geographic
data
artificial
intelligence
refine
biogeographical
inference,
offering
more
profound
insights
into
structure
Asia,
significant
implications
applications.
The Innovation Life,
Год журнала:
2025,
Номер
unknown, С. 100131 - 100131
Опубликована: Янв. 1, 2025
<p>Large-scale
genomic
resources
from
biobank
sequencing
projects
are
crucial
for
understanding
the
interplay
between
environmental
and
genetic
factors
in
human
disease
health
traits,
as
well
reconstructing
evolutionary
history.
We
summarize
recent
advances
cohorts
highlight
opportunities
non-Eurocentric
populations
a
multidisciplinary
perspective.
Initiatives
like
UK100K,
All
of
Us,
TOPMed
precision
medicine
programs
have
shifted
research
paradigms
problem-derived
to
data-driven
approaches,
enhancing
our
architecture
diseases
Europeans
their
descendants.
However,
biases
persist,
such
Han
bias
Chinese
focused
on
medical
anthropological
purposes.
These
contribute
global
inequalities
disparities
medicine.
Evolutionary
studies
modern
ancient
genomes
provide
new
insights
into
history
adaptive
trajectories
critical
mutations.
findings
underscore
importance
personal
genome
tailored
ethnolinguistically
genetically
diverse
populations.
This
strategy
is
vital
assessing
burden
etiology
disease.
Our
work
emphasizes
need
include
underrepresented
diversity
create
comprehensive
catalog
variations
understand
biological
implications.</p>
Genome Biology and Evolution,
Год журнала:
2024,
Номер
16(11)
Опубликована: Ноя. 1, 2024
Abstract
The
earlier
version
of
AncestryPainter
is
a
Perl
program
that
displays
the
ancestry
composition
numerous
individuals
using
rounded
graph.
Motivated
by
requests
users
in
practical
applications,
we
updated
to
2.0
coding
an
R
package
and
improving
layout,
providing
more
options
compatible
statistical
functions
for
graphing.
Apart
from
visualization
per
se
this
update,
added
extra
graphing
module
visualize
genetic
distance
through
radial
bars
varying
lengths
surrounding
core.
Notably,
allows
multiple
pie
charts
at
center
graph
display
than
one
target
population
implements
method
admixture
history
infer
sequence
populations.
We
validated
six
metrics
both
simulated
real
data
implemented
Pearson
coefficient-based
metric
with
best
performance
2.0.
Furthermore,
was
merge
proportion
matrices.
freely
available
https://github.com/Shuhua-Group/AncestryPainterV2
https://pog.fudan.edu.cn/#/Software.
