A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant

Food Chemistry X, Год журнала: 2025, Номер 25, С. 102125 - 102125

Опубликована: Янв. 1, 2025

The present study reveals in vitro antioxidant properties and the phytochemical content of a novel Rheum species (Rheum telianum), which grows Southeastern Anatolia. To perform analysis, dried leaves seeds plants were ground extracted with ethanol to obtain plant secondary metabolites activity. Then, extracts subjected DPPH scavenging Cupric reducing (CUPRAC), Fe3+, Ferric power (FRAP). In addition capacity assays, quantitative phenolic, flavonoid, metabolite determined through spectrophotometric LC-MS/MS chromatographic methods. IC50 values showed that both R. telianum have high inhibitory over radicals 20.79 5.67 μg/mL, respectively. samples' dominant evaluated analysis results. inhibition effects on acetylcholinesterase butyrylcholinesterase, α-glycosidase human carbonic anhydrases II isoenzyme enzymes, associated some global diseases including Alzheimer's disease, type-2 diabetes mellitus glaucoma determined. conclusion, extracts' contents functional relationship plants' possible usage food, medicine, cosmetic industries was revealed.

Язык: Английский

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New Peripheral Pyridine‐Substituted Cobalt, Copper, and Manganese Phthalocyanines as Potential In Vitro Acetyl/Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 18, 2025

ABSTRACT In this research, we designed phthalocyanine compounds that are thought to be used as potential acetyl/butyrylcholinesterase inhibitors in the treatment of Alzheimer's disease. First, phthalonitrile compound ( PNM‐CN ), which is precursor for phthalocyanines, was synthesized. Then, by cyclotetramerizing compound, pyridine‐substituted peripheral cobalt PNM‐CoPc copper PNM‐CuPc and manganese PNM‐MnClPc ) were synthesized, their structures described using mass, NMR (except phthalocyanines), FT‐IR, UV–Vis phthalonitrile) spectroscopic techniques. Investigations carried out into new PNM‐Cu/Co/MnClPcs phthalocyanines' vitro inhibitory properties against butyrylcholinesterase (BuChE) acetylcholinesterase (AChE). With an IC 50 5.95 ± 2.12 μM (AChE) 0.74 0.01 (BuChE), showed most potent effect AChE BuChE among all compounds.

Язык: Английский

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Antioxidant, anti-acetylcholinesterase potentials, ADME estimations and molecular docking studies of green algae extracts

European Journal of Life Sciences, Год журнала: 2025, Номер 4(1), С. 24 - 35

Опубликована: Апрель 30, 2025

Algae have become the center of attention due to their strong antioxidants and enzyme-inhibitory activities. In this study, green algae (Enteromorpha linza) extracts obtained using acetone, hexane methanol were investigated. antioxidant properties, anti-acetylcholinesterase (AChE) potential, ADME estimations molecular docking analyses The best binding position was by sirsimaritin, daidzein, kaempferol, morin myricetin active site acetylcholinesterase receptor. Docking score values calculated as -10.0, -10.3, -9.9, -9.8 kcal/mol, respectively. Experimental analysis revealed that showed inhibitory activity against enzyme. Acetone extract good inhibition performance with IC50 0.0379 mg/ml 0.0414 mg/ml, value for determined 0.997 mg/ml. When results evaluated in terms both DPPH ABTS radical scavenging capacities, it acetone-based had a higher capacity (DPPH: 17.48%, ABTS: 83.58%) compared other solvents. general, examined can be used source natural agents beneficial human health.

Язык: Английский

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The new metal-free, zinc, magnesium, indium ball-type phthalocyanines and their hybrids with graphene oxide: Synthesis, investigation of photophysical, photochemical properties and theoretical studies

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер 461, С. 116138 - 116138

Опубликована: Ноя. 7, 2024

Язык: Английский

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Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies

Medicinal Chemistry Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Язык: Английский

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Porphyrin Schiff bases as potential Alzheimer's disease drug candidates: Synthesis, in silico and DFT studies

Journal of Molecular Structure, Год журнала: 2024, Номер 1327, С. 141251 - 141251

Опубликована: Дек. 29, 2024

Язык: Английский

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