Biosensors and Bioelectronics, Год журнала: 2025, Номер 283, С. 117539 - 117539
Опубликована: Май 2, 2025
Язык: Английский
Clinics and Practice, Год журнала: 2025, Номер 15(1), С. 14 - 14
Опубликована: Янв. 6, 2025
This study analyzes urinary tract infections (UTIs) in a hospital Central Portugal over five-year period, focusing on bacterial prevalence, patient demographics, and antibiotic resistance patterns. investigation aims to provide insights that can guide improved infection control treatment strategies. A total of 6161 positive urine cultures collected five years were examined, with particular emphasis 2019 due peak rates. The analysis explored demographic factors such as sex clinical service origin, resistance. Special attention was given hospitalized patients, especially those undergoing invasive procedures, their increased vulnerability infection. found UTIs more prevalent female reflecting anatomical susceptibilities. Hospitalized individuals, particularly requiring at greater risk. predominant bacteria Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, differences prevalence by origin. Resistance Imipenem E. coli increased, raising concerns about last-resort treatments. However, other antibiotics declined, suggesting improvements recent stewardship measures. During the COVID-19 pandemic, overall consumption decreased changes practices. findings highlight importance strict control, targeted prevention measures, rational use combat Ongoing surveillance personalized approaches are essential improve UTI management outcomes.
Язык: Английский
Процитировано
2
European Urology, Год журнала: 2024, Номер 86(3), С. 195 - 197
Опубликована: Май 13, 2024
Язык: Английский
Процитировано
6
Сибирский научный медицинский журнал, Год журнала: 2025, Номер 45(1), С. 148 - 157
Опубликована: Фев. 27, 2025
The urobiome is being actively studied, diagnostics are improved and new markers of inflammatory diseases the urinary tract searched for, despite fact that most microorganisms unidentified their functions remain not fully understood. aim study was to composition microbiota (urobiota) in patients with liver cirrhosis, depending on presence infection. Material methods. A prospective cohort single-center conducted 48 cirrhosis (30 men, 18 women), who, addition standard studies, underwent metagenomic sequencing urine feces. average age examined 50.5 years, there were 16 32 without infection, respectively. High-performance performed using MiSeq genetic analyzer (Illumina, USA) a protocol based analysis variable regions 16s rRNA gene. Data Kraken2 algorithm. significance level α assumed be 0.05. registered Clinicaltrials.gov (NCT05335213). results discussion. dominant phylotypes urobiota Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, among which Proteobacteria predominate (more than 50 %). beta diversity has significant differences or infection (p = 0.001). Urinary increases density such taxa as Gammaproteobacteria, including Escherichia, Klebsiella, Acinetobacter, Enterobacter, well Bacilli, Synergistia, Deltaproteobacteria, Epsilonproteobacteria, Acidithiobacillia decreases Prevotella, Clostridioides, Brevundimonas, Delftia, Stenotrophomonas, Streptococcus < 0.05). Conclusions. Microbiological identification method made it possible identify more 1,000 types uncultivated ones, characteristic bacterial pattern expands understanding pathogenesis diagnostic possibilities infections creates prerequisites for substantiating directions modulation personalization patient treatment.
Язык: Английский
Процитировано
0
Lecture notes on data engineering and communications technologies, Год журнала: 2025, Номер unknown, С. 77 - 88
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biosensors and Bioelectronics, Год журнала: 2025, Номер 283, С. 117539 - 117539
Опубликована: Май 2, 2025
Язык: Английский
Процитировано
0