Estimating the two consecutive epidemic waves of SARS-CoV-2 Omicron in Shenzhen, China from November 2022 to July 2023: a modeling study based on multi-source surveillance and mobility data

Advances in Continuous and Discrete Models, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 9, 2025

Язык: Английский

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An Epidemic Model with Infection Age and Vaccination Age Structure

Infectious Disease Reports, Год журнала: 2024, Номер 16(1), С. 35 - 64

Опубликована: Янв. 10, 2024

A model of epidemic dynamics is developed that incorporates continuous variables for infection age and vaccination age. The analyzes pre-symptomatic symptomatic periods an infected individual in terms This property shown to be major importance the severity epidemic, when infectious period precedes period. also efficacy immunity vaccinated individuals varies with significance epidemic. Application 2003 SARS Taiwan COVID-19 New York provides insights into these diseases. It outbreak was effectively contained due complete overlap periods, allowing timely isolation affected individuals. In contrast, spread led a rapid, uncontrolled These findings underscore critical strategies influencing

Язык: Английский

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Heterogeneity of SARS-CoV-2 immune responses after the nationwide Omicron wave in China

Microbiology Spectrum, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

ABSTRACT It remains unclear how previous infections and vaccinations influenced shaped heterogeneous immune responses against Omicron its variants in diverse populations China. After the national wave of early 2023, we evaluated serum levels neutralizing antibodies (nAbs) (B.1.1.529) (BA.5, BF.7, CH1.1) 33 COVID-19 convalescents 40 uninfected vaccinees, using vesicular stomatitis virus-based pseudovirus assay. In addition, followed 34 Delta convalescent patients to compare their before (late 2021) after (early 2023). NAbs at acute phase disease were investigated 50 inpatients, including 24 vaccinated 26 unvaccinated patients. Among them, nasal mucosal IgA measured 42 subjects. Compared vaccination, breakthrough significantly increased breadth magnitude nAbs variants. Exposure but not elicited stronger pan-Omicron responses. continued rise as vaccination doses increased. However, both vaccinees convalescents, a fourth dose did elicit higher Omicron. Furthermore, lasted longer than WT SARS-CoV-2. Breakthrough specific compared infection. Although repeated revealed limited impacts on nAbs, high risk hospitalization may still benefit from vaccination. IMPORTANCE The study described humoral immunity populations, Delta-positive patients, Omicron-infected with or current confirmed infection, Omicron-positive healthy controls. for 1 year evaluate effect booster vaccine, reinfection. Nasal SARS-CoV-2 also examined. findings this demonstrated varied individuals different states following outbreak Omicron, highlighting potential advantages ongoing immunization groups that are more vulnerable have greater likelihood being hospitalized.

Язык: Английский

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Sleep disorder experienced by healthcare nurses after terminating Zero-COVID-19 policy

BMC Nursing, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 9, 2024

Abstract Objective Medical staff, especially nurses, suffered great anxiety and stress from the COVID-19 pandemic, which negatively affected their sleep quality. In this study, we aimed to analyze quality of nursing staff after terminating Zero-COVID-19 policy in China. Methods 506 participants were involved our study. The Pittsburgh Sleep Quality Index (PSQI) was used evaluate status participants. Binary regression performed impact factors related difficulty. Results majority (96.44%) disturbances. There significant differences age, education level front-line activity between with good Younger age (16–25 years old) independently associated less difficulty, while severe Conclusion disorder very common among nurses ending More difficulty particular, should be worthy attention.

Язык: Английский

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Dynamic changes in the circulation of respiratory pathogens in children during and after the containment of the 2019 coronavirus disease pandemic in Kunming, China

European Journal of Clinical Microbiology & Infectious Diseases, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

We aimed to determine the changes in frequency of respiratory pathogens and severe acute syndrome coronavirus 2 (SARS-CoV-2) during containment 2019 disease pandemic elucidate epidemiological interference that may have occurred after lifting measures.

Язык: Английский

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