Global incidence and mortality of severe fungal disease

The Lancet Infectious Diseases, Год журнала: 2024, Номер 24(7), С. e428 - e438

Опубликована: Янв. 21, 2024

Язык: Английский

---

Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap

The Lancet Microbe, Год журнала: 2023, Номер 4(6), С. e470 - e480

Опубликована: Апрель 27, 2023

Candida parapsilosis is one of the most commen causes life-threatening candidaemia, particularly in premature neonates, individuals with cancer haematopoietic system, and recipients organ transplants. Historically, drug-susceptible strains have been linked to clonal outbreaks. However, worldwide studies started since 2018 reported severe outbreaks among adults caused by fluconazole-resistant strains. Outbreaks are associated high mortality rates can persist despite strict infection control strategies. The emergence resistance threatens efficacy azoles, which widely used class antifungals only available oral treatment option for candidaemia. fact that patients infected azole-naive underscores potential adaptability diverse hosts, environmental niches, reservoirs. Another concern multidrug-resistant echinocandin-tolerant C isolates, emerged 2020. Raising awareness, establishing effective clinical interventions, understanding biology pathogenesis urgently needed improve strategies outcomes.

Язык: Английский

---

Impact of climate change and natural disasters on fungal infections

The Lancet Microbe, Год журнала: 2024, Номер 5(6), С. e594 - e605

Опубликована: Март 19, 2024

The effects of climate change and natural disasters on fungal pathogens the risks for diseases remain incompletely understood. In this literature review, we examined how fungi are adapting to an increase in Earth's temperature becoming more thermotolerant, which is enhancing fitness virulence. Climate creating conditions conducive emergence new priming adapt previously inhospitable environments, such as polluted habitats urban areas, leading geographical spread some traditionally non-endemic areas. also contributing increases frequency severity disasters, can trigger outbreaks pathogens. populations mostly affected socially vulnerable. More awareness, research, funding, policies part key stakeholders needed mitigate disaster-related diseases.

Язык: Английский

---

Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

Clinical Microbiology Reviews, Год журнала: 2023, Номер 36(3)

Опубликована: Июль 13, 2023

Fungal endocarditis accounts for 1% to 3% of all infective cases, is associated with high morbidity and mortality (>70%), presents numerous challenges during clinical care. Candida spp. are the most common causes fungal endocarditis, implicated in over 50% followed by Aspergillus Histoplasma Important risk factors include prosthetic valves, prior heart surgery, injection drug use.

Язык: Английский

---

Social determinants of health as drivers of fungal disease

EClinicalMedicine, Год журнала: 2023, Номер 66, С. 102325 - 102325

Опубликована: Ноя. 18, 2023

Disparities in social determinants of health (SDOH) play a significant role causing inequities globally. The physical environment, including housing and workplace can increase the prevalence spread fungal infections. A number professions are associated with increased infection risk low pay, which may be linked to crowded sub-optimal living conditions, exposure organisms, lack access quality care, for infection. Those involved displaced from areas armed conflict have an invasive Lastly, plant pathogens already threaten food security, will become more problematic global climate change. Taken together, disparities SDOH contracting More emphasis needs placed on systematic approaches better understand impact reducing these disparities.

Язык: Английский

---

Paving the way for affordable and equitable liposomal amphotericin B access worldwide

The Lancet Global Health, Год журнала: 2024, Номер 12(9), С. e1552 - e1559

Опубликована: Авг. 14, 2024

Amphotericin B has long been crucial for treating many serious infectious diseases, such as invasive fungal infections and visceral leishmaniasis, particularly patients who are immunocompromised, including those with advanced HIV infection. The conventional amphotericin deoxycholate formulation largely replaced in high-income countries liposomal (LAmB), which advantages, lower rates of adverse events, nephrotoxicity anaemia. Despite an evident need LAmB low-income middle-income countries, where mortality from is still substantial, often use the because a small number generic formulations high price originator LAmB. pricing also highly variable between countries. Overcoming supply barriers through availability additional quality-assured, at accessible prices would substantially facilitate equitable access have substantial effect on attributable to deadly infections.

Язык: Английский

---

Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp.

Journal of Fungi, Год журнала: 2023, Номер 9(4), С. 500 - 500

Опубликована: Апрель 21, 2023

With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare species. This review aims to give an overview of the management aspergillosis (IA) non-fumigatus Aspergillus spp.—namely A. flavus, terreus, niger nidulans—including diagnostic therapeutic differences similarities fumigatus. flavus is second most common spp. isolated in patients with IA predominant species subtropical regions. Treatment complicated its intrinsic resistance against amphotericin B (AmB) high minimum inhibitory concentrations (MIC) for voriconazole. nidulans has been frequently long-term immunosuppression, mostly primary immunodeficiencies such as chronic granulomatous disease. It reported disseminate more often than other Innate AmB suggested but not yet proven, while MICs seem be elevated. less severe infections otomycosis. Triazoles exhibit varying therefore strictly recommended first-line treatment niger, patient outcome seems favorable when compared due terreus-related have increasingly cause acute aspergillosis. A recent prospective international multicenter surveillance study showed Spain, Austria, Israel countries highest density terreus complex isolates collected. dissemination intrinsically resistant AmB. Non-fumigatus difficult manage histories, infection sites potential resistances antifungals. Future investigational efforts should aim at amplifying knowledge specific measures their on-site availability, well defining optimal strategies outcomes

Язык: Английский

---

Point-of-care testing for viral-associated pulmonary aspergillosis

Expert Review of Molecular Diagnostics, Год журнала: 2023, Номер 24(3), С. 231 - 243

Опубликована: Сен. 9, 2023

Over the last years, severe respiratory viral infections, particularly those caused by acute syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role earlier thus improve patient outcomes.

Язык: Английский

---

The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies

Therapeutic Advances in Infectious Disease, Год журнала: 2025, Номер 12

Опубликована: Янв. 1, 2025

Anthropogenic climate change, primarily driven by greenhouse gas emissions, is reshaping ecosystems and creating conditions that affect 58% of all known human infectious diseases, including fungal infections. Specifically, increasing temperatures, changing precipitation patterns, extreme weather events are influencing growth, distribution, virulence. These factors may expand the geographic range pathogenic fungi, exposing populations to novel, potentially more virulent, or drug-resistant strains. Simultaneously, such as declining immunity, aging populations, increased use immunosuppressive therapies enhancing host susceptibility. This review explores intricate relationship between change infections, highlighting pathogens demonstrate virulence antifungal resistance, along with emerging novel pathogens. The clinical implications profound, morbidity, mortality, spread infections into new regions. Immediate action required develop policies, educational initiatives, therapies, enhance early diagnostic capabilities, address healthcare disparities mitigate growing burden

Язык: Английский

---

Elevating fungal care: bridging Brazil’s healthcare practices to global standards

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

ABSTRACT Brazil faces unique challenges in managing invasive fungal infections (IFIs) due to diverse ecosystems, a rural workforce, and prevalent health conditions. In Europe, IFIs are primarily associated with transplantation, intensive care, chronic diseases. Inspired by initiatives the Caribbean Latin America 2019, efforts map global diagnostic treatment resources expanded Africa, Asia/Pacific. This study conducts comparative analysis, mainly drawing data from investigate IFI epidemiology management. Data were collected through online surveys distributed Brazilian European institutions, collaborations scientific organizations. Surveys covered institutional profiles, diagnoses, accessibility techniques, antifungal drugs. A survey involving 96 388 institutions revealed variations perception practices related pathogens. Differences ranking prevalence observed, along procedures, fluorescence dye usage, culture practices, medication availability, technological approaches. Europe exhibited higher utilization rates for molecular approaches, including PCR tests, therapeutic drug monitoring (TDM) was more widespread compared Brazil, indicating substantial differences understanding infections. Customized management is crucial, considering regional addressing gaps like underutilized PCR. The advocates increased international collaboration, targeted training, enhanced foster unified approach preventing, diagnosing, treating IFI. IMPORTANCE work significant as it highlights its ecosystems public landscape. By comparing Brazil’s situation Europe—where linked transplantation care—this identifies key disparities practices. findings reveal availability use of diagnostics, drugs, monitoring, demonstrating advanced mapping these variations, underscores importance tailored approaches that consider gaps. Ultimately, calls resource allocation improve outcomes globally, particularly regions limited access tools treatments.

Язык: Английский

---