Making sense of sentinels: wildlife as the one health bridge for environmental antimicrobial resistance surveillance
Journal of Applied Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Antimicrobial
resistance
(AMR),
arising
from
decades
of
imprudent
anthropogenic
use
antimicrobials
in
healthcare
and
agriculture,
is
considered
one
the
greatest
One
Health
crises
facing
globally.
pollutants
released
human-associated
sources
are
intensifying
evolution
environment.
Due
to
various
ecological
factors,
wildlife
interact
with
these
polluted
ecosystems,
acquiring
resistant
bacteria
genes.
Although
recognised
reservoirs
disseminators
AMR
environment,
current
surveillance
systems
still
primarily
focus
on
clinical
agricultural
settings,
neglecting
this
environmental
dimension.
Wildlife
can
serve
as
valuable
sentinels
reflecting
ecosystem
health,
effectiveness
mitigation
strategies.
This
review
explores
knowledge
gaps
surrounding
factors
influencing
acquisition
dissemination
wildlife,
highlights
limitations
policy
instruments
that
do
not
sufficiently
address
component
AMR.
We
discuss
underutilised
opportunity
using
sentinel
species
a
holistic,
Health-centred
system.
By
better
integrating
into
systematic
policy,
leveraging
advances
high-throughput
technologies,
we
track
predict
evolution,
assess
impacts,
understand
complex
dynamics
transmission
across
ecosystems.
Язык: Английский
Longitudinal Trends and Drivers of Antimicrobial Resistance in Campylobacter Worldwide (1954-2023)
Zoonoses,
Год журнала:
2025,
Номер
5(1)
Опубликована: Янв. 1, 2025
Objective:
The
zoonotic
pathogen
Campylobacter
is
a
major
foodborne
bacterial
species
worldwide.
distribution
and
drivers
of
antimicrobial
resistance
(AMR)
in
global
strains
remain
largely
unknown.
Therefore,
comprehensive
analysis
longitudinal
trends
driving
factors
AMR
necessary
at
level.
Methods:
We
downloaded
from
public
repositories
66,771
genomes
(24,115
C.
coli
42,656
jejuni
)
53
countries/regions
during
1954–2023,
performed
analysis.
Results:
categorized
the
isolates
into
2,771
sequence
types
(STs),
45
which
were
shared
among
humans,
chickens,
pigs,
cattle,
environment.
uncovered
spatial
temporal
characteristics
across
classes
on
scale,
observed
increased
aminoglycoside,
tetracycline,
fluoroquinolone
past
23
years.
Some
antibiotic,
climate,
socioeconomic
indicators
collected
World
Bank
might
potentially
have
driven
rise
various
to
varying
degrees.
Conclusions:
In
summary,
we
present
genetic
atlas
,
provides
valuable
insights
for
understanding
transmission
dynamics
this
species.
Язык: Английский
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal ( Canis aureus ) gut
mSphere,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
ABSTRACT
The
spread
of
antimicrobial
resistance
(AMR)
is
a
critical
One
Health
issue.
Wildlife
could
act
as
reservoirs
or
vehicles
AMR
bacteria
(ARBs)
and
genes
(ARGs)
but
are
relatively
understudied.
We
sought
to
investigate
clinically
relevant
ARGs
in
golden
jackals
(
Canis
aureus
)
thriving
near
human
settlements
Israel.
Fecal
samples
were
collected
from
111
across
four
regions
over
10-month
period.
Various
animal
spatio-temporal
metadata
collected.
Samples
analyzed
by
quantitative
PCR
(qPCR)
for
beta-lactamases
bla
TEM,
CTX-M15,
SHV),
qnrS
int1
.
A
subset
was
subject
shotgun
metagenomic
sequencing
followed
resistome
microbiome
analyses.
qPCR
detected
high
prevalence
ARGs,
including
TEM-1,
96.4%;
CTX-M-15,
51.4%,
SHV,
15.3%),
fluoroquinolone
,
87.4%),
class
1
integrons
Int1
94.6%).
TEM-1
gene
found
be
more
prevalent
adult
compared
younger
ones.
Metagenomic
analysis
revealed
diverse
gut
harboring
rich
with
tetracycline
being
the
most
prevalent.
Metagenome-assembled
genome
further
identified
several
associated
bacteria.
These
findings
highlight
potential
role
emphasize
need
ongoing
surveillance
better
understand
transmission
dynamics
at
wildlife–human
interface.
IMPORTANCE
research
highlights
(AMR).
these
emphasizes
monitoring
Язык: Английский
Systematic review and meta-analysis of antimicrobial resistant bacteria in free-ranging wild mammals
BMC Veterinary Research,
Год журнала:
2025,
Номер
21(1)
Опубликована: Март 7, 2025
Bacterial
antimicrobial
resistance
is
a
significant
global
threat
to
public
health,
closely
linked
the
misuse
of
antimicrobials
in
human
and
veterinary
medicine,
aquaculture,
agriculture.
The
consequences
overcome
species
boundaries
require
holistic
approach
for
mitigation
actions.
study
wildlife
thus
increasingly
relevant
understand
spread
environment
animal
community,
as
well
investigate
role
either
carrier,
reservoir,
spillover,
or
indicator
resistance.
aim
this
describe
prevalence
type
bacterial
isolates
from
wild
mammals
through
systematic
review
meta-analysis
available
literature,
following
Preferred
Reporting
Items
Systematic
reviews
Meta-Analysis
(PRISMA)
guidelines.
Out
5052
collected
documents,
3795
were
screened,
finally
139
studies
on
free-ranging
included
meta-analysis.
covered
37
countries,
mostly
European.
Enterobacterales
Escherichia
coli
Salmonella
spp.,
Campylobacter
most
frequently
targeted
species,
mainly
Artiodactyla
order
specifically
Suidae
Cervidae
families.
Low
moderate
prevalences
found
all
continents,
bacteria,
host
taxa,
meta-analysis,
even
critically
important
defined
by
World
Health
Organisation,
with
higher
values
Africa
Asia,
carnivores,
high
adaptability
diverse
habitats.
This
showed
that
widespread
variable
according
taxonomy,
trophic
source,
geographic
location.
highlighted
methodological
gaps
need
be
addressed
improve
interpretation
conclusions
obtained
data.
Genetic
analyses
population
ecological
data
should
future
analysis
achieve
standardised
methodology
current
limitations.
To
date,
appears
an
environmental
surveillance
plans
not
only
because
sentinel
but
also
monitor
potential
spill-back
livestock
and/or
humans.
Язык: Английский
From Rivers to Tap: The Spread of Antimicrobial Resistance in Drinking Water Systems
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
The
water
environment
plays
a
prominent
role
in
the
spread
of
antimicrobial
resistance
(AMR).
Water
discharges
from
hospitals
and
animal
farms
are
hotspots
harbouring
antibiotic-resistant
bacteria
(ARB)
genes
(ARGs).
From
this
discharge,
ARB
can
be
further
transmitted
via
bodies,
including
river
used
for
drinking,
hygiene,
recreational
activities,
posing
risks
to
community.
Although
AMR
surveillance
primarily
focuses
on
clinical
agricultural
settings,
monitoring
drinking
system
has
been
neglected.
Studies
worldwide
have
shown
presence
supplies.
However,
not
yet
recognised
as
parameter
quality.
Research
systems
is
still
lacking
many
countries,
highlighting
urgent
need
public
health
action
importance
guiding
policymakers
towards
achieving
Sustainable
Development
Goals
(SDGs),
particularly
SDG
6:
“Clean
&
Sanitation”
3:
“Good
wellbeing”.
Therefore,
it
crucial
address
gap
by
providing
more
evidence
systems,
worldwide.
Here,
we
discussed
challenges
implications
AMR,
emphasising
occurrence
ARB,
ARGs
antibiotics
residues
system,
well
recommendations
policy
management
reduce
risks.
Язык: Английский
Optimization of the large-scale production for Erwinia amylovora bacteriophages
Microbial Cell Factories,
Год журнала:
2024,
Номер
23(1)
Опубликована: Дек. 23, 2024
Fire
blight,
caused
by
Erwinia
amylovora,
poses
a
significant
threat
to
global
agriculture,
with
antibiotic-resistant
strains
necessitating
alternative
solutions
such
as
phage
therapy.
Scaling
therapy
an
industrial
level
requires
efficient
mass-production
methods,
particularly
in
optimizing
the
seed
culture
process.
In
this
study,
we
investigated
large-scale
E.
amylovora
production
media
supplementation
and
fermenter
conditions,
focusing
on
minimizing
phages
pathogenic
reduce
risks
improve
We
optimized
inoculum
concentrations
supplements
achieve
higher
yields
comparable
or
exceeding
conventional
methods.
Laboratory-scale
validation
refinement
for
fermenter-scale
allowed
us
bacterial
levels
10⁵
CFU/mL
10³
PFU/mL,
respectively.
Using
fructose
sucrose
supplements,
were
methods
that
use
10⁸
host
bacteria
10⁷
PFU/mL
phages.
Further
pH
adjustments
increased
16–303%
across
all
tested.
demonstrated
successful
optimization
scale-up
of
production,
emphasizing
potential
bioprocessing
reduced
cells
seeds.
Overall,
refining
key
parameters,
established
robust
scalable
method
enhancing
efficiency.
Язык: Английский
Environmental contamination by veterinary medicinal products and their implications in the conservation of the endangered Pyrenean Capercaillie (Tetrao urogallus aquitanicus)
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
288, С. 117299 - 117299
Опубликована: Ноя. 16, 2024
Язык: Английский