Polymer Bulletin, Год журнала: 2022, Номер 80(1), С. 165 - 183
Опубликована: Янв. 28, 2022
Язык: Английский
Bioactive Materials, Год журнала: 2022, Номер 19, С. 458 - 473
Опубликована: Май 2, 2022
The relationships between hyaluronic acid (HA) and pathological microorganisms incite new understandings on microbial infection, tissue penetration, disease progression lastly, potential treatments. These are important for the advancement of next generation antimicrobial therapeutical strategies control healthcare-associated infections. Herein, this review will focus interplay HA, bacteria, fungi, viruses. This also comprehensively detail discuss activity displayed by various HA molecular weights a variety biomedical pharmaceutical applications, including microbiology, pharmaceutics, engineering.
Язык: Английский
Процитировано
106
Polymers, Год журнала: 2022, Номер 14(16), С. 3266 - 3266
Опубликована: Авг. 11, 2022
Bleeding control plays a very important role in worldwide healthcare, which also promotes research and development of wound dressings. The healing process involves four stages hemostasis, inflammation, proliferation remodeling, is complex process, dressings play huge it. Electrospinning technology simple to operate. Electrospun nanofibers have high specific surface area, porosity, oxygen permeability, excellent mechanical properties, show great utilization value the manufacture As one most popular reactive functional synthetic polymers, polyacrylonitrile (PAN) frequently explored create for wide variety applications. In recent years, researchers invested application PAN Research on spun reviewed, future directions prospects electrospun are proposed.
Язык: Английский
Процитировано
84
Human Vaccines & Immunotherapeutics, Год журнала: 2022, Номер 18(5)
Опубликована: Март 8, 2022
Multiple vaccines have recently been developed, and almost all the countries are presently vaccinating their population to tackle COVID-19 pandemic. Most of in use administered via intramuscular (IM) injection, eliciting protective humor cellular immunity. intranasal (IN) also being developed that shown promising ability induce a significant amount antibody-mediated immune response robust cell-mediated immunity as well hold added stimulate mucosal along with additional advantage ease administration compared IM injected vaccines. By inducing secretory IgA antibody responses specifically nasal compartment, SARS-CoV-2 vaccine can prevent virus infection, replication, shedding, disease development, possibly limits transmission. This article highlights current progress, advantages, prospects, challenges developing for countering ongoing
Язык: Английский
Процитировано
83
Advanced Functional Materials, Год журнала: 2023, Номер 33(49)
Опубликована: Сен. 7, 2023
Abstract Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, highly designable capacity, HA hydrogels have been emerging biomaterial, showing tailoring performance in terms modifications hydrogel forms. Various preparation technologies developed the fabrication unique structures functions. They utilized diverse biomedical applications like drug delivery tissue engineering scaffolds. Herein, this review comprehensively summarizes derivatives different molecule weights functional modifications. Then various methods obtain forms nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, scaffold are reviewed as well. The emphasis focused on shining these anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis diagnosis, etc. potentials prospects subsequently given inspire further investigation, aiming at accelerating product translation from research clinic.
Язык: Английский
Процитировано
79
Deleted Journal, Год журнала: 2024, Номер 6(8)
Опубликована: Авг. 15, 2024
Alginate, a naturally sourced bio-polymer derived mainly from brown seaweed, has gained incredible attention due to its versatile properties and wide range of applications. This review outlines alginate regarding sources, extraction methods, classifications, critical characteristics. The development alginate, focusing on application in 3D bioprinting fields such as vascular tissue formation, bone printing, cartilage been discussed. Recent trends the different sectors, cosmetic textiles wastewater treatment, wound dressing, preparation intelligent materials, have also probed. techniques used, benefits, limitations form discussion each application. In addition, future perspectives are discussed by considering current research with potential innovations that can expand utility. Particular is devoted promising role these emerging technologies hold promise for radical changes many industries biocompatibility, biodegradability, unique physicochemical properties. seeks lay down basic knowledge synthesizing state art and, this way, brings out gaps might inspire further studies dynamic field.
Язык: Английский
Процитировано
22
Small, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Abstract Nanovaccines, as a new generation of vaccines, have garnered significant interest due to their exceptional potential in enhancing disease prevention and treatment. Their unique features, such high stability, antigens protection, prolonged retention, targeted delivery lymph nodes, immune cells, tumors, set them apart promising candidates the field immunotherapy. Polymers, with superior degradability, capacity mimic pathogen characteristics, surface functionality that facilitates modifications, serve ideal carriers for vaccine components. Polymer‐based self‐adjuvanted nanovaccines remarkable ability augment responses. The inherent adjuvant‐like properties polymers themselves offer pathway toward more efficient exploitation nanomaterials optimization nanovaccines. This review article aims summarize categorization elucidate mechanisms action adjuvants. Additionally, it delves into advantages limitations polymer‐based management prevention, providing valuable insights design application. comprehensive analysis could contribute development effective tailored wide range diseases.
Язык: Английский
Процитировано
3
Nutrients, Год журнала: 2021, Номер 13(11), С. 3960 - 3960
Опубликована: Ноя. 6, 2021
Beta-glucans comprise a group of polysaccharides natural origin found in bacteria, algae, and plants, e.g., cereal seeds, as well microfungi macrofungi (mushrooms), which are characterized by diverse structures functions. They known for their metabolic immunomodulatory properties, including anticancer, antibacterial, antiviral. Recent reports suggest potential beta-glucans the prevention treatment COVID-19. In contrast to β-glucans from other sources, mushrooms β-1,3-glucans with short β-1,6-side chains. This structure is recognized receptors located on surface immune cells; thus, mushroom have specific properties gained BRM (biological response modifier) status. Moreover, also owe formation triple helix conformation, one key factors influencing bioactivity beta-glucans. review summarizes latest findings biological health-promoting civilization viral diseases, particular emphasis
Язык: Английский
Процитировано
81
International Journal of Biological Macromolecules, Год журнала: 2021, Номер 200, С. 498 - 519
Опубликована: Дек. 30, 2021
Язык: Английский
Процитировано
74
Vaccines, Год журнала: 2022, Номер 10(11), С. 1906 - 1906
Опубликована: Ноя. 11, 2022
With the support of modern biotechnology, vaccine technology continues to iterate. The safety and efficacy vaccines are some most important areas development in field. As a natural substance, chitosan is widely used numerous fields—such as immune stimulation, drug delivery, wound healing, antibacterial procedures—due its good biocompatibility, low toxicity, biodegradability, adhesion. Chitosan-based nanoparticles (NPs) have attracted extensive attention with respect adjuvants delivery systems due their excellent properties, which can effectively enhance responses. Here, we list classifications mechanisms action adjuvants. At same time, preparation methods chitosan, NPs, mechanism system introduced. applications NPs protein nucleic acid also This paper reviewed latest research progress chitosan-based adjuvant systems.
Язык: Английский
Процитировано
65
Advances in Colloid and Interface Science, Год журнала: 2022, Номер 303, С. 102653 - 102653
Опубликована: Март 22, 2022
Язык: Английский
Процитировано
60