Cyperus Kyllingia leaf extract mediated biosynthesis of silver nanoparticles: Assessment of their anticancer, photocatalytic activity and interaction with human serum albumin DOI

Somenath Kundu,

Samaresh Paria,

Basudev Shit

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100344 - 100344

Опубликована: Апрель 1, 2025

Язык: Английский

Development of a Novel Human Serum Albumin-Based Tool for Effective Drug Discovery: The Investigation of Protein Quality and Immobilization DOI Creative Commons
Balázs Kenéz, Gábor Koplányi,

Balázs Decsi

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

The binding ability of human serum albumin (HSA) on active pharmaceutical ingredients (APIs) is one the most important parameters in early stages drug discovery. In this study, an immobilized HSA-based tool was developed for rapid and easy vitro screening API binding. work explored serious incompleteness identification HSA used published last five years. To mitigate problem, a comprehensive analysis immobilization studies were performed types. Serious differences colloidal stability HSAs their selected set APIs observed. magnetic nanoparticles with glutardialdehyde (GDA) or cyclohexyl-diglycidyl ether (CDGE) linkers, which have never been before. HSA-MNP-CDGE complexes achieved higher yield preserved ability; however, esterase-like enzymatic activity reduced significantly.

Язык: Английский

Процитировано

0
Association between blood–urea–nitrogen-to-albumin ratio and in-hospital mortality in patients diagnosed with coronavirus disease 2019: a retrospective cohort study DOI Creative Commons
Ruoqing Zhou, Dianzhu Pan

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 4, 2025

The blood–urea–nitrogen-to-albumin ratio (BAR) is recognized as a novel prognostic indicator; however, there limited number of studies investigating the relationship between BAR and in-hospital mortality associated with coronavirus disease 2019 (COVID-19). Therefore, present investigation aims to explore correlation in patients COVID-19 China. This retrospective observational study enrolled cohort 1027 diagnosed December 2022 March 2023. Multivariate Cox regression analyses were used ascertain independent association among COVID-19. Furthermore, stratified investigate potential interaction effects variables, such age, sex, Severity, hypertension, coronary artery disease, diabetes mellitus. A total 117 (11.4%) died from various causes during hospitalization. Subsequent adjustment for confounding highest tertile exhibited an elevated risk relative those lowest (hazard [HR] 2.44 [95% confidence interval CI 1.24–4.79]) when was treated categorical variable. When considering continuous variable, 6% increase prevalence observed each 1-unit (adjusted HR 1.06 1.03–1.08]; P < 0.001). Stratified revealed consistent due significant COVID-19, suggesting that higher poorer prognosis. However, further research required confirm these findings.

Язык: Английский

Процитировано

0
Exploring the Binding Dynamics of Anticancer Dihydropyrimidinone Derivatives with Serum Albumin: A Multispectral Approach DOI Creative Commons

Chandraprakash Gond,

Shivani Daksh,

Akanksha Mishra

и другие.

Chemical Physics Impact, Год журнала: 2025, Номер unknown, С. 100851 - 100851

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Applications, challenges, and future perspective of albumin in drug delivery DOI
Ankaj Kumar,

Akhila Reddy,

Adinath Dadhale

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 621 - 658

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Cyperus Kyllingia leaf extract mediated biosynthesis of silver nanoparticles: Assessment of their anticancer, photocatalytic activity and interaction with human serum albumin DOI

Somenath Kundu,

Samaresh Paria,

Basudev Shit

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100344 - 100344

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0