Dual-Functional Drug Delivery System for Bisphosphonate-Related Osteonecrosis Prevention and Its Bioinspired Releasing Model and In Vitro Assessment DOI Creative Commons
Piyarat Sungkhaphan, Boonlom Thavornyutikarn, Papon Muangsanit

и другие.

ACS Omega, Год журнала: 2023, Номер 8(29), С. 26561 - 26576

Опубликована: Июль 14, 2023

Clindamycin (CDM)/geranylgeraniol (GGOH)-loaded plasma-treated mesoporous silica nanoparticles/carboxymethyl chitosan composite hydrogels (CHG60 and CHG120) were developed for the prevention of medication-related osteonecrosis jaw associated with bisphosphonates (MRONJ-B). The pore structure performances CHGs, e.g., drug release profiles kinetics, antibacterial activity, zoledronic acid (ZA)-induced cytotoxicity reversal acute cytotoxicity, evaluated. bioinspired platform mimicking in vivo fibrin matrices was also proposed vitro/in correlation. CHG120 further encapsulated human-derived fibrin, generating FCHG120. SEM μCT images revealed interconnected porous structures both pure fibrin-surrounding %porosity 75 36%, respectively, indicating presence inside hydrogel pores, besides its peripheral region, which evidenced by confocal microscopy. co-presence GGOH moderately decelerated overall releases CDM from CHGs studied releasing fluids, i.e., phosphate buffer saline-based fluid (PBB) simulated interstitial (SIF). whole-lifetime patterns CDM, fitted Ritger-Peppas equation, appeared nondifferentiable, divided into two stages, rapid steady whereas biphasic observed Phase I II Higuchi equations, respectively. Notably, burst drugs subsided lengthier durations (up to 10-12 days) SIF, compared those PBB, enabling elicit satisfactory ZA activities MRONJ-B prevention. network FCHG120 reduced sustained at least 14 days, lengthening bactericidal FCHG decreasing vitro ovo toxicity. This highlighted significance as appropriate vivo-like platforms evaluate performance an implant.

Язык: Английский

Biodegradable Controlled Drug Delivery Platform Based on Carboxylated Mesoporous Silica Nanoparticles––Zinc Oxide Quantum Dots DOI
J. Q. Li, Hai-Ying Chen,

Rui Qian

и другие.

Industrial & Engineering Chemistry Research, Год журнала: 2024, Номер 63(31), С. 13459 - 13468

Опубликована: Июль 24, 2024

A biodegradable delivery platform is constructed for controlled drug delivery. Carboxylated mesoporous silica nanoparticles (COOH–BMSNs) are synthesized to load the chemotherapy methotrexate (MTX), and mesopores of BMSN blocked by ZnO quantum dots (QDs) through an amidation reaction encapsulate loaded MTX. The QDs decomposed under mildly acidic conditions which characteristic a tumor microenvironment, resulting in release MTX; additionally, glutathione (GSH) can reduce disulfide bonds (−S–S−) into sulfhydryl (−SH), causing decomposition Therefore, responsiveness pH GSH MTX be achieved with ZnO–BMSN–MTX. Notably, vitro cytotoxicity testing reveals that drug-free carrier (ZnO–BMSN) exhibits good biocompatibility, whereas (ZnO–BMSN–MTX) significant against SMMC-7721 cells benefiting from synergistic effect Zn2+.

Язык: Английский

Процитировано

1
A stimuli-responsive drug delivery system based on konjac glucomannan, carboxymethyl chitosan and mesoporous polydopamine nanoparticles DOI

Zherui Zhao,

Wanting Shi,

Yufei Wu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139196 - 139196

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Synthesis of novel composite hydrogel based on carboxymethyl cellulose/acrylamide/β-cyclodextrin for drug delivery DOI

Ziang Quan,

Xiaohui Wang,

K.-L. Zheng

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138387 - 138387

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0
Degradable chiral mesoporous silica nanoparticles and carboxymethyl chitosan/cystamine hydrogels for selective loading and controlled release of S-naproxen DOI

Ze Xu,

Guodong Zhang, Rongzhi Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 288, С. 138706 - 138706

Опубликована: Дек. 11, 2024

Язык: Английский

Процитировано

0
Dual-Functional Drug Delivery System for Bisphosphonate-Related Osteonecrosis Prevention and Its Bioinspired Releasing Model and In Vitro Assessment DOI Creative Commons
Piyarat Sungkhaphan, Boonlom Thavornyutikarn, Papon Muangsanit

и другие.

ACS Omega, Год журнала: 2023, Номер 8(29), С. 26561 - 26576

Опубликована: Июль 14, 2023

Clindamycin (CDM)/geranylgeraniol (GGOH)-loaded plasma-treated mesoporous silica nanoparticles/carboxymethyl chitosan composite hydrogels (CHG60 and CHG120) were developed for the prevention of medication-related osteonecrosis jaw associated with bisphosphonates (MRONJ-B). The pore structure performances CHGs, e.g., drug release profiles kinetics, antibacterial activity, zoledronic acid (ZA)-induced cytotoxicity reversal acute cytotoxicity, evaluated. bioinspired platform mimicking in vivo fibrin matrices was also proposed vitro/in correlation. CHG120 further encapsulated human-derived fibrin, generating FCHG120. SEM μCT images revealed interconnected porous structures both pure fibrin-surrounding %porosity 75 36%, respectively, indicating presence inside hydrogel pores, besides its peripheral region, which evidenced by confocal microscopy. co-presence GGOH moderately decelerated overall releases CDM from CHGs studied releasing fluids, i.e., phosphate buffer saline-based fluid (PBB) simulated interstitial (SIF). whole-lifetime patterns CDM, fitted Ritger-Peppas equation, appeared nondifferentiable, divided into two stages, rapid steady whereas biphasic observed Phase I II Higuchi equations, respectively. Notably, burst drugs subsided lengthier durations (up to 10-12 days) SIF, compared those PBB, enabling elicit satisfactory ZA activities MRONJ-B prevention. network FCHG120 reduced sustained at least 14 days, lengthening bactericidal FCHG decreasing vitro ovo toxicity. This highlighted significance as appropriate vivo-like platforms evaluate performance an implant.

Язык: Английский

Процитировано

1