Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 1, 2024
Asthma,
being
the
prevailing
respiratory
ailment
globally,
remains
enigmatic
in
terms
of
its
pathogenesis.
In
recent
times,
advancement
traditional
Chinese
medicine
pertaining
to
intestinal
microbiota
has
yielded
a
plethora
investigations,
which
have
substantiated
potential
disease
prevention
and
treatment
through
modulation
microbiota.
Both
animal
models
clinical
trials
unequivocally
demonstrated
indispensable
role
pathogenesis
asthma.
This
article
presents
summary
therapeutic
effects
context
regulating
gut
metabolites,
thereby
achieving
immune
regulation
inhibiting
airway
inflammation
associated
with
It
elucidates
mechanism
by
modulates
enhance
asthma
management,
offering
scientific
foundation
for
utilization
Foods,
Год журнала:
2024,
Номер
13(9), С. 1336 - 1336
Опубликована: Апрель 26, 2024
Asthma
is
a
prevalent
respiratory
disease.
The
present
study
designed
to
determine
whether
gut
microbiota-derived
tryptophan
metabolites
alleviate
allergic
asthma
inflammation
in
ovalbumin
(OVA)-induced
mice
and
explore
the
effect
potential
mechanism
therein.
model
were
constructed
by
OVA
treatment,
kynurenine
(KYN),
indole-3-lactic
acid
(ILA),
in-dole-3-carbaldehyde
(I3C),
indole
acetic
(IAA)
administered
intraperitoneal
injection.
percent
survival,
weight
symptom
score
of
recorded.
total
immunoglobulin
E
OVA-specific
(s)IgE
serum
inflammatory
cytokines
bronchoalveolar
lavage
fluid
(BALF)
detected
corresponding
ELISA
kits.
composition
microbiota
tryptophan-targeted
metabolism
mouse
feces
analyzed
using
16S
rRNA
gene
sequencing
targeted
metabolomics,
respectively.
four
improved
symptoms
mice,
reduced
cells
lung
tissues,
especially
I3C.
I3C
IAA
significantly
(p
<
0.05)
downregulated
levels
OVA-IgE
cytokines.
KYN
was
observed
help
restore
diversity.
Additionally,
I3C,
KYN,
ILA
increased
relative
abundance
Anaeroplasma,
Akkermansia,
Ruminococcus_1,
respectively,
which
connected
with
metabolic
pathways.
also
enhanced
capability
microbiota,
restoring
increasing
production
other
metabolites.
These
findings
suggest
that
may
modulate
through
offering
benefits
for
clinical
management.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 26, 2024
Edible
fungus
polysaccharides
have
garnered
significant
attention
from
scholars
due
to
their
safety
and
potential
anti-inflammatory
activity.
However,
comprehensive
summaries
of
properties
are
still
rare.
This
paper
provides
a
detailed
overview
the
effects
mechanisms
these
polysaccharides,
as
well
impact
on
inflammation-related
diseases.
Additionally,
relationship
between
structure
activity
is
discussed.
It
believed
that
this
review
will
greatly
enhance
understanding
application
edible
in
treatments,
thereby
significantly
promoting
development
utilization
fungi.
Experimental and Molecular Pathology,
Год журнала:
2025,
Номер
142, С. 104964 - 104964
Опубликована: Апрель 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Molecules,
Год журнала:
2023,
Номер
28(19), С. 6816 - 6816
Опубликована: Сен. 27, 2023
Traditional
Chinese
medicine
(TCM)
is
a
class
of
natural
drugs
with
multiple
components
and
significant
therapeutic
effects
through
targets.
It
also
originates
from
wide
range
sources
containing
plants,
animals
minerals,
among
them,
plant-based
includes
fungi.
Fungal
traditional
medicinal
resource
long
history
widespread
application
in
China.
Accumulating
evidence
confirms
that
polysaccharide
the
main
pharmacodynamic
material
on
which
fungal
TCM
based.
The
purpose
current
systematic
review
to
summarize
extraction,
isolation,
structural
identification,
biological
functions,
quality
control
edible
applications
polysaccharides
past
three
years.
This
paper
will
supplement
deepen
understanding
TCM,
propose
some
valuable
insights
for
further
research
development
functional
foods.
