Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2018 - 2018
Опубликована: Дек. 16, 2024
Nanoparticles
(NPs)
have
emerged
as
a
potent
choice
for
various
applications,
from
drug
delivery
to
agricultural
studies,
serving
an
alternative
and
promising
methodology
future
advancements.
They
been
widely
explored
in
systems,
demonstrating
immense
promise
high
efficiency
the
of
numerous
biomolecules
such
proteins
anticancer
agents,
either
solely
or
modified
with
other
compounds
enhance
their
capabilities.
In
addition,
utilization
NPs
extends
antimicrobial
where
they
are
used
develop
novel
antibacterial,
antifungal,
antiviral
formulations
advanced
characteristics.
Lactoferrin
(Lf)
is
glycoprotein
recognized
its
significant
multifunctional
properties,
antimicrobial,
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Its
activity
has
broad
distribution
human
body,
Lf
receptors
present
multiple
regions.
Current
research
shows
that
utilized
NP
technology
surface
material,
encapsulated
biomolecule,
even
itself.
Due
abundance
regions,
can
be
employed
material
targeted
strategies,
particularly
crossing
BBB
targeting
specific
cancers.
Furthermore,
synthesized
structure,
positioning
it
strong
candidate
NP-related
applications.
this
article,
we
explore
highlighted
underexplored
areas
applications
research.
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0312866 - e0312866
Опубликована: Дек. 3, 2024
To
find
an
effective
inhibitor
for
SARS-CoV-2,
Quercetin’s
chemical
structure
was
compared
to
nine
ligands
associated
with
key
SARS-CoV-2
proteins.
It
found
that
Quercetin
closely
resembles
Remdesivir,
the
co-crystallized
ligand
of
RNA-dependent
RNA
polymerase
(RdRp).
This
similarity
confirmed
through
flexible
alignment
experiments
and
molecular
docking
studies,
which
showed
both
Remdesivir
bind
similarly
active
site
RdRp.
Molecular
dynamics
(MD)
simulations
over
a
200
ns
trajectory,
analyzing
various
factors
like
RMSD,
RG,
RMSF,
SASA,
hydrogen
bonding
were
conducted.
These
gave
detailed
insights
into
binding
interactions
RdRp
Remdesivir.
Further
analyses,
including
MM-GBSA,
Protein-Ligand
Interaction
Fingerprints
(ProLIF)
Profile
PLIP
stability
binding.
Principal
component
analysis
trajectories
(PCAT)
provided
coordinated
movements
within
systems
studied.
In
vitro
assays
is
highly
in
inhibiting
RdRp,
IC
50
122.1
±5.46
nM,
better
than
Remdesivir’s
21.62
±2.81
μM.
Moreover,
greater
efficacy
against
,
1.149
μg/ml
9.54
μg/ml.
The
selectivity
index
(SI)
values
highlighted
safety
margin
(SI:
791)
6).
conclusion,
our
comprehensive
study
suggests
promising
candidate
further
research
as
providing
valuable
developing
anti-COVID-19
treatment.
Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2018 - 2018
Опубликована: Дек. 16, 2024
Nanoparticles
(NPs)
have
emerged
as
a
potent
choice
for
various
applications,
from
drug
delivery
to
agricultural
studies,
serving
an
alternative
and
promising
methodology
future
advancements.
They
been
widely
explored
in
systems,
demonstrating
immense
promise
high
efficiency
the
of
numerous
biomolecules
such
proteins
anticancer
agents,
either
solely
or
modified
with
other
compounds
enhance
their
capabilities.
In
addition,
utilization
NPs
extends
antimicrobial
where
they
are
used
develop
novel
antibacterial,
antifungal,
antiviral
formulations
advanced
characteristics.
Lactoferrin
(Lf)
is
glycoprotein
recognized
its
significant
multifunctional
properties,
antimicrobial,
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Its
activity
has
broad
distribution
human
body,
Lf
receptors
present
multiple
regions.
Current
research
shows
that
utilized
NP
technology
surface
material,
encapsulated
biomolecule,
even
itself.
Due
abundance
regions,
can
be
employed
material
targeted
strategies,
particularly
crossing
BBB
targeting
specific
cancers.
Furthermore,
synthesized
structure,
positioning
it
strong
candidate
NP-related
applications.
this
article,
we
explore
highlighted
underexplored
areas
applications
research.
