International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4571 - 4587
Опубликована: Апрель 1, 2025
Topical
application
of
17β-estradiol
(E2)
has
been
shown
to
improve
various
hallmark
features
skin
aging,
including
enhancing
elasticity
and
hydration,
reducing
wrinkles,
promoting
collagen
synthesis.
However,
the
role
estrogen
in
UVB-induced
photoaging
remains
unclear.
Furthermore,
E2's
clinical
is
limited
by
issues
such
as
bioavailability
potential
adverse
effects.
Therefore,
this
study
aims
explore
E2
prepare
a
gold
(Au)@mesoporous
polydopamine
(mPDA)-hyaluronic
acid
(HA)/carboxymethyl
chitosan
(CMCS)
nanoparticle
composite
hydrogel
(Au/E2@mPDA-HCG)
for
treatment
photoaging.
This
successfully
fabricated
mPDA
with
well-defined
mesoporous
structure
incorporated
Au
NPs
into
mesopores
using
an
situ
growth
method,
thereby
constructing
Au@mPDA
loaded
E2.
Subsequently,
Au/E2@mPDA
were
embedded
HA/CMCS
develop
Au/E2@mPDA-HCG
hydrogel.
The
was
characterized
through
vitro
vivo
experiments,
its
efficacy
improving
evaluated.
revealed
that
deficiency
significantly
exacerbates
photoaging,
likely
mechanisms
closely
associated
increased
oxidative
stress
reduced
production.
Moreover,
demonstrated
favorable
morphological
characteristics
biocompatibility.
In
experimental
results
indicated
effectively
enhanced
therapeutic
treating
evidenced
significant
mitigation
inflammatory
responses,
along
promotion
conclusion,
suggests
combination
Au@mPDA@HCG
nanocomposite
offers
promising
strategy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июнь 2, 2024
Abstract
Hydrogels
are
dynamically
evolving
3D
networks
composed
of
hydrophilic
polymer
scaffolds
with
significant
applications
in
the
healthcare
and
environmental
sectors.
Notably,
protein‐based
hydrogels
mimic
extracellular
matrix,
promoting
cell
adhesion.
Further
enhancing
proliferation
within
these
matrix‐metalloproteinase‐triggered
amino
acid
motifs.
Integration
cell‐friendly
modules
like
peptides
proteins
expands
hydrogel
functionality.
These
exceptional
properties
position
for
diverse
applications,
including
biomedicine,
biosensors,
remediation,
food
industry.
Despite
progress,
there
is
ongoing
research
to
optimize
biomedical
further.
Engineering
novel
favorable
characteristics
crucial
regulating
tissue
architecture
facilitating
ecological
remediation.
This
review
explores
synthesis,
physicochemical
properties,
biological
implications
various
types
their
extensive
biomedicine
It
elaborates
on
potential
bridging
gap
between
advancements
sector
solutions
issues.
Materials,
Год журнала:
2024,
Номер
17(10), С. 2439 - 2439
Опубликована: Май 18, 2024
This
comprehensive
review
delves
into
the
world
of
hyaluronic
acid
(HA)
hydrogels,
exploring
their
creation,
characteristics,
research
methodologies,
and
uses.
HA
hydrogels
stand
out
among
natural
polysaccharides
due
to
distinct
features.
Their
exceptional
biocompatibility
makes
them
a
top
choice
for
diverse
biomedical
purposes,
with
great
ability
coexist
harmoniously
living
cells
tissues.
Furthermore,
biodegradability
permits
gradual
breakdown
by
bodily
enzymes,
enabling
creation
temporary
frameworks
tissue
engineering
endeavors.
Additionally,
since
is
vital
component
extracellular
matrix
(ECM)
in
numerous
tissues,
can
replicate
ECM's
structure
functions.
mimicry
pivotal
applications
providing
an
ideal
setting
cellular
growth
maturation.
Various
cross-linking
techniques
like
chemical,
physical,
enzymatic,
hybrid
methods
impact
mechanical
strength,
swelling
capacity,
degradation
speed
hydrogels.
Assessment
tools
such
as
rheological
analysis,
electron
microscopy,
spectroscopy,
tests,
studies
are
employed
examine
attributes.
HA-based
feature
prominently
engineering,
drug
distribution,
wound
recovery,
ophthalmology,
cartilage
mending.
Crafting
enables
production
biomaterials
sought-after
qualities,
offering
avenues
advancements
realm
biomedicine.
