ABSTRACT
The
utilization
of
nanoformulations
derived
from
natural
products
for
the
treatment
many
human
diseases,
including
cancer,
is
a
rapidly
developing
field.
Conventional
therapies
used
cancer
have
limited
efficacy
and
greater
number
adverse
effects.
Hence,
it
imperative
to
develop
innovative
anticancer
drugs
with
superior
effectiveness.
Among
diverse
array
compounds,
resveratrol,
curcumin,
epigallocatechin
gallate
(EGCG)
gained
considerable
attention
in
recent
years.
Despite
their
strong
properties,
medicinally
significant
phytochemicals
such
as
EGCG
certain
disadvantages,
solubility
water,
stability,
bioavailability
problems.
Encapsulating
these
poly(lactic‐
co
‐glycolic
acid)
(PLGA),
polymer
that
nontoxic,
biodegradable,
biocompatible,
an
effective
method
delivering
medication
tumor
location.
In
addition,
PLGA
nanoparticles
can
be
modified
targeting
molecules
specifically
target
cells,
thereby
improving
effectiveness
fighting
tumors.
Combining
plant‐based
medicine
(phytotherapy)
nanotechnology
clinical
environment
has
potential
enhance
improve
overall
health
outcomes
patients.
Therefore,
crucial
comprehensive
understanding
different
aspects
advancements
using
PLGA‐based
nanocarriers
phytochemicals.
This
review
addresses
most
delivery
systems
EGCG,
emphasizing
possibility
resolving
issues
related
therapeutic
compounds.
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
31(4), С. 244 - 260
Опубликована: Апрель 30, 2024
In
recent
years,
advancements
in
chemistry
have
allowed
the
tailoring
of
materials
at
nanoscopic
level
as
needed.
There
are
mainly
four
main
types
nanomaterials
used
drug
carriers:metal-based
nanomaterials,
organic
inorganic
and
polymer
nanomaterials.
The
a
carrier
showed
advantages
for
decreased
side
effects
with
higher
therapeutic
index.
stability
compounds
increased
by
encapsulation
within
nano-drug
carriers,
leading
to
systemic
toxicity.
Nano-drug
carriers
also
controlled
release
system-made
solubility
characteristics
nanoparticles
surface
coating
surfactants.
review
focuses
on
different
nanoparticle
synthesis
process,
techniques
purposes,
applications
prospects
biomedical
applications.
Analytical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
As
one
of
the
most
harmful
heavy
metal
pollutants,
hexavalent
chromium
Cr(VI)
is
becoming
a
serious
threat
to
human
health.
Thus
pursuing
remarkably
sensitive
method
monitor
concentration
in
natural
conditions
favored
for
fast
response
prevent
harm.
In
present
work,
an
ethylenediamine
(En)
and
SiO2-modified
wool
keratin-based
carbon
quantum
dot
(CQD)(En@CQDs@SiO2)
fluorescent
sensor
prepared,
En
found
improve
discrimination
ability
by
binding
with
surface
carboxyl
groups.
Based
on
these
designs,
En@CQDs@SiO2
achieves
significant
improvement
detection
ability,
limit
6.08
×
10–4
mg/L,
which
succeeded
6
times
over
CQDs,
better
than
conventional
UV–Vis
flame
atomic
absorption
(AAS)
techniques.
Furthermore,
has
good
relative
sensitivity,
selectivity,
spectral
reproducibility,
excellent
structural
stability.
These
properties
make
suitable
environmental
detection,
undoubtedly
improves
economy
friendliness
sensor.
Abstract
The
growing
presence
of
pharmaceutical
pollutants
in
aquatic
environments
poses
significant
threats
to
both
human
health
and
ecosystems.
Despite
their
crucial
role
healthcare,
pharmaceuticals
enter
water
systems
through
various
sources,
making
them
some
the
most
critical
environmental
contaminants.
Traditional
wastewater
treatments,
which
are
classified
into
physical,
chemical,
biological
techniques,
often
struggle
effectively
remove
pharmaceuticals.
Among
these
methods,
adsorption
stands
out
as
a
reliable
versatile
approach
for
removing
organic
enhancing
efficiency
treatment
processes.
Biopolymers,
particularly
chitosan,
gaining
attention
due
numerous
advantages,
including
biocompatibility,
biodegradability,
affordability,
high
capability,
non‐toxicity,
availability
from
diverse
natural
sources.
Chitosan,
hydrophilic
biopolymer,
can
be
chemically
modified
by
incorporating
nanoparticles
(e.g.,
metal
oxides,
carbon‐based
materials,
magnetic
particles)
boost
its
efficiency.
These
advancements
enable
chitosan‐based
nanocomposites
range
pharmaceuticals,
antibiotics,
analgesics,
hormones,
water.
This
review
examines
latest
developments
nanocomposite
adsorbents,
emphasizing
fundamental
mechanisms,
optimization
conditions,
kinetic
behaviors,
isotherm
models.
factors
collectively
determine
capturing
pollutants.
Moreover,
underscores
potential
materials
remediation,
offering
valuable
insights
application
future
research
directions.
Ultimately,
aim
this
is
provide
insight
offer
an
innovative
effective
solution
challenge
contamination
By
addressing
key
challenges
utilizing
advanced
material
designs,
adsorbents
hold
great
promise
sustainable
efficient
removal
systems.
Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Using
carbon‐based
nanoparticles,
such
as
diamond,
graphite,
fullerene,
and
nanotubes,
has
increased
their
research
possible
strategies
for
drug
delivery
to
control
diseases,
especially
cancer.
However,
because
these
materials,
when
interacting
with
the
living
environment,
release
substances
that
are
capable
of
inducing
cell
death
by
themselves,
it
is
vital
importance
analyze
type
particle
can
induce.
Although
there
different
efforts
describe
kind
nanoparticles
used
treat
diseases
cancer,
no
paper
explains
mechanisms
induced
nanoparticle
systems.
Therefore,
this
attempts
gain
cutting‐edge
information
on
using
nanopolymorphisms
mechanism
particles
produce.
In
conclusion,
carbon
interact
directly
membranes,
causing
physical
damage
disturbing
integrity
membrane.
This
alteration
mainly
lead
necrosis
or
apoptosis.
The
definition
a
predominant
each
depends
dose‐dependent
manner.
Primarily,
concentrations
cytotoxicity
were
100–500
μg/mL.
several
studies
analyzed,
was
only
find
nanodiamonds
proved
not
be
cytotoxic.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(5)
Опубликована: Сен. 1, 2024
Cancer
is
considered
a
formidable
global
health
threat,
despite
substantial
strides
in
diagnosis,
detection,
and
therapeutic
strategies.
Remarkable
progress
has
been
achieved
these
realms,
yet
the
survival
rates
for
cancer
patients
have
persisted
at
suboptimal
levels
over
decades.
Acknowledging
need
to
address
ongoing
challenges
rates,
research
efforts
are
being
made
push
boundaries
of
innovation
diagnostic
techniques,
bioimaging,
drug
delivery
technologies.
Over
past
few
years,
nano(bio)technology-based
approaches
applied
biosensing
imaging
applications
detect
biochemical
substances
various
matrices.
Among
nanoengineered
particulates,
quantum
dots
(QDs)
recognized
as
versatile
agents
applications.
QDs,
often
called
artificial
atoms,
characterized
by
remarkable
optical
electrical
features
which
essential
cytosensing,
localized
bioimaging
therapeutics.
Here
this
review,
we
discussed
QDs
sensitive
selective
precise
sensing
cells.
Both
electrochemical
used
describe
cytosensing
detection
methods.
Furthermore,
malignant
tumor
cells
with
responses
also
highlighted.
This
review
lists
several
kinds
that
frequently
such
applications,
carbon,
graphene,
zinc,
other
types
hybrid-based
QDs.
Finally,
shed
insight
on
prospective
research,
advantages
potential
In
article,
emphasize
limitations
difficulties
associated
clinical
order
provide
insights
solutions.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(9)
Опубликована: Март 2, 2024
Abstract
Cancer
stands
as
a
leading
cause
of
global
mortality,
with
chemotherapy
being
pivotal
treatment
approach,
either
alone
or
in
conjunction
other
therapies.
The
primary
goal
these
therapies
is
to
inhibit
the
growth
cancer
cells
specifically,
while
minimizing
harm
healthy
dividing
cells.
Conventional
treatments,
often
causing
patient
discomfort
due
side
effects,
have
led
researchers
explore
innovative,
targeted
cell
Thus,
biopolymer‐based
aerogels
emerge
innovative
platforms,
showcasing
unique
properties
that
respond
intelligently
diverse
stimuli.
This
responsiveness
enables
precise
control
over
release
anticancer
drugs,
enhancing
therapeutic
outcomes.
significance
lies
their
ability
offer
drug
delivery
increased
efficacy,
biocompatibility,
and
high
payload.
In
this
comprehensive
review,
author
discuss
role
an
emerging
functionalized
platforms
delivery.
review
addresses
showing
smart
behavior
responding
different
stimuli
including
temperature,
pH,
magnetic
redox
potential
release.
Finally,
discusses
application
aerogel
delivering
drugs
also
gene
applications.