The theranostic potential of green nanotechnology-enabled gold nanoparticles in cancer: A paradigm shift on diagnosis and treatment approaches
Results in Chemistry,
Год журнала:
2023,
Номер
7, С. 101264 - 101264
Опубликована: Дек. 16, 2023
The
application
of
nanotechnology
to
cancer
research
has
resulted
in
substantial
advancements.
In
this
study,
gold
nanoparticles
(AuNPs)
synthesised
utilising
environmentally
friendly
methods
are
evaluated
for
their
potential
as
multipurpose
theranostic
agents
treatment.
These
eco-friendly
AuNPs
attractive
candidates
applications
that
combine
diagnosis
and
therapy
due
specific
physicochemical
features.
Green
practises
use
only
sustainable,
biocompatible
materials
promote
biocompatibility
biomedical
while
reducing
environmental
impact.
Imaging
techniques
such
optical
coherence
tomography,
surface-enhanced
Raman
scattering,
photoacoustic
imaging
can
benefit
from
part
properties.
Their
surface
plasmon
resonance
(SPR)
be
adjusted,
improving
contrast
allowing
tailored
administration
therapeutic
payloads.
localised
SPR
effect
also
increases
the
efficacy
photothermal
treatment
(PTT)
by
converting
near-infrared
light
into
heat
inducing
hyperthermia
cells.
Because
heating,
may
ablated
precisely
with
minimal
collateral
damage.
observed
assessed
real
time
a
multimodal
platform,
addition
being
used
diagnostic
tools.
primary
focus
is
on
recent
breakthroughs
production
using
green
techniques,
particularly
those
have
occurred
beyond
2020,
theranostics.
We
investigating
various
functionalizing
ligands,
medications,
order
improve
efficacy.
go
over
regulatory
considerations
toxicity
assessments
must
considered
when
bringing
these
nanomaterials
clinical
use,
well
exist.
Язык: Английский
Strategic Developments in Polymer-Functionalized Liposomes for Targeted Colon Cancer Therapy: An Updated Review of Clinical Trial Data and Future Horizons
Biomacromolecules,
Год журнала:
2024,
Номер
25(9), С. 5650 - 5669
Опубликована: Авг. 20, 2024
Liposomes,
made
up
of
phospholipid
bilayers,
are
efficient
nanocarriers
for
drug
delivery
because
they
can
encapsulate
both
hydrophilic
and
lipophilic
drugs.
Conventional
cancer
treatments
sometimes
involve
considerable
toxicities
adverse
reactions
(ADRs),
which
limits
their
clinical
value.
Despite
liposomes'
promise
in
addressing
these
concerns,
trials
have
revealed
significant
limitations,
including
stability,
targeted
distribution,
scaling
challenges.
Recent
focused
on
enhancing
liposome
formulations
to
increase
therapeutic
efficacy
while
minimizing
negative
effects.
Notably,
the
approval
liposomal
medications
like
Doxil
demonstrates
potential
treatment.
However,
intricacy
preparation
requirement
comprehensive
regulatory
remain
substantial
impediments.
Current
trial
updates
show
continued
efforts
improve
targeting
mechanisms,
payload
capacity
order
address
issues.
The
future
therapy
depends
challenges
provide
patients
with
more
effective
safer
treatment
alternatives.
Язык: Английский
Advancements in Skin Cancer Treatment: 5-Fluorouracil and Carvedilol-Loaded Transethosomes Using Lipoid S100
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 36
Опубликована: Апрель 1, 2025
This
study
investigates
a
hybrid
drug
delivery
system
combination
of
5-Fluorouracil
(5-FU)
and
Carvedilol
(CVD)
for
enhanced
chemotherapeutic
efficacy
in
skin
cancer
treatment.
The
approach
addresses
challenges
such
as
resistance
suboptimal
conventional
therapies.
Transethosomes
(TEs)
were
developed
using
the
Modified
Ethanol
Injection
method,
with
optimization
based
on
concentrations
Lipoid
S100,
Tween
80,
Polyvinyl
Alcohol,
ethanol
via
Box-Behnken
Design.
Characterization
techniques,
including
FT-IR,
DSC,
Raman
spectroscopy,
XRD,
FESEM,
TEM,
AFM,
utilized
to
evaluate
formulations.
In
vitro
anticancer
studies,
IC50
determination,
MTT
assays,
cell
cycle
analysis,
conducted
alongside
permeation
hemolysis
evaluations
performed
ex
vivo.
optimized
transethosome
formulation
demonstrated
particle
size
113
nm,
zeta
potential
27.23
mV,
encapsulation
efficiencies
97.21%
5-FU
98.73%
CVD.
Spectroscopic
analyses
indicated
no
significant
drug-excipient
interactions,
while
XRD
confirmed
amorphous
nature
formulation.
Microscopy
revealed
spherical
vesicles
uniform
coating.
showed
activity
studies.
CVD
within
transethosome-based
presents
alternative
topical
chemotherapy
treatment,
offering
therapeutic
efficacy.
underscores
carriers
advancing
targeted
Язык: Английский
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(10), С. 727 - 741
Опубликована: Март 1, 2024
Abstract:
This
review
investigates
the
revolutionary
application
of
cell
membrane-coated
nanoparticles
(CMNPs)
as
a
promising
avenue
for
cancer
therapy
within
embryonic
landscape
nanotechnology.
Nanoparticles,
pivotal
in
treatment,
are
systematically
examined
their
diverse
physicochemical
structures,
categorized
organic
(lipid-based,
protein-based,
and
polymer-assisted)
inorganic
(carbon-based
metal)
varieties.
A
significant
focus
is
placed
on
CMNPs,
which
serve
an
innovative
drug
delivery
vehicle,
overcoming
limitations
associated
with
conventional
nanoparticle
therapies.
manuscript
accurately
explores
advantages
challenges
various
membranes,
including
those
derived
from
cells,
red
blood
platelets,
stem
white
cells.
Importance
roles
enhancing
precision,
immune
system
circumvention,
targeted
recognition.
Detailed
insights
into
crafting
CMNPs
provided,
elucidating
membrane
extraction
fusion
techniques,
such
sonication,
extrusion,
co-extrusion,
microfluidic
electroporation.
Maintaining
integrity
during
benefits
coating
techniques
augmenting
biocompatibility
underscored.
comprehensive
resource
consolidates
latest
advancements
delivery,
positioning
itself
at
forefront
nanotechnology
biomedicine
research.
Encapsulating
methodologies
like
electrospray,
chemical
conjugation,
this
showcases
expanding
toolbox
available
to
researchers
dynamic
field.
Focusing
unique
characteristics
multifaceted
applications
biomedical
research,
particularly
tumour
therapy.
It
provides
indepth
analysis
stability,
evasion
capabilities,
increased
payload
capacity,
retained
biological
functionality.
The
outlines
current
future
prospects
chemotherapy,
photothermal
photodynamic
therapy,
immunotherapy,
gene
therapeutic
methods.
concludes
by
highlighting
transformative
potential
reshaping
treatment.
Язык: Английский