Oral chitosan-cyclodextrin “shell-core” nanoparticles co-loaded Rhein and chlorogenic acid for ulcerative colitis treatment DOI

Wenbiao Nie,

Wenzhen Zhong,

Qian Lin

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138493 - 138493

Опубликована: Дек. 1, 2024

Язык: Английский

Development of multifunctional chitosan-based composite film loaded with tea polyphenol nanoparticles for strawberry preservation DOI

Yuxin Li,

Ziqi Hua,

Yangjing Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133648 - 133648

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

9
Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases DOI Creative Commons
Xueli Bai, Tianfei Zhou, Xiaowen Wu

и другие.

Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Almond polysaccharides inhibit DSS-induced inflammatory response in ulcerative colitis mice through NF-κB pathway DOI

Yanqi Peng,

Jiayi Zhu,

Yingshuo Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136206 - 136206

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

4
A phlorotannin nanoparticle–hydrogel composite for enhanced oral delivery and treatment of ulcerative colitis DOI
Wen Jiang,

Xu Yu,

Xinchuang Wang

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Designing innovative strategies for oral delivery of active compounds is particularly promising the treatment intestinal diseases such as ulcerative colitis (UC).

Язык: Английский

Процитировано

0
Ophiopogonis Radix fructan-selenium nanoparticles for dual amelioration of ulcerative colitis and anti-colon cancer DOI
Bohan Jia,

Wenna Yang,

Hongyu Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 142327 - 142327

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0
Isolation of a novel polysaccharide from Tribonema minus and preparation of polysaccharide–selenium nanoparticles with enhanced antioxidant activity DOI
Rundong Yang, Yuhao Guo, Yanchao Mao

и другие.

Algal Research, Год журнала: 2025, Номер unknown, С. 104020 - 104020

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Enzymatic Oxidants, Antioxidants, and Inflammatory Bowel Disease DOI Creative Commons
R. Steven Esworthy

Applied Biosciences, Год журнала: 2025, Номер 4(2), С. 19 - 19

Опубликована: Апрель 1, 2025

The role of oxidants and antioxidants in inflammatory bowel disease (IBD) has been actively explored since the early 1980s, starting with respiratory burst neutrophils ischemia pathology. Since that time, enzymatic components contributing to pool reactive oxygen species, including superoxide, H2O2, lipid hydroperoxides, counteracting antioxidants—catalase, glutathione peroxidases (Gpx), peroxiredoxins (PRDX), superoxide dismutases, others—have fleshed out. My perspective on IBD is from balance or imbalance oxidant sources process. I will present evidence involvement antioxidant processes based, as much possible, my experiences Gpxs. This be discussed terms both immune system local systems. As Gpxs are generally selenium-dependent, possible deficiencies selenium uptake active impact Gpx expression explored. more recently introduced ferroptosis, an iron-dependent peroxidation-based pathological process, reviewed for its IBD.

Язык: Английский

Процитировано

0
Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers DOI
Kung‐Hwa Wei,

Xiaoxue Yin,

Fangjiao Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142791 - 142791

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis. DOI Creative Commons

Fengyu Shi,

Akmal Ergashev,

Zhenyan Pan

и другие.

Materials Today Bio, Год журнала: 2024, Номер 30, С. 101406 - 101406

Опубликована: Дек. 15, 2024

Acute pancreatitis (AP) is a highly fatal pancreatic inflammation. In recent years, synthetic nanoparticles have been extensively developed as drug carriers to address the challenges of systemic adverse reactions and lack specificity in delivery. However, systemically administered nanoparticle therapy rapidly cleared from circulation by mononuclear phagocyte system (MPS), leading suboptimal concentrations inflamed tissues pharmacokinetics. To this challenge, we herein demonstrate surface masking strategy that involves coating selenylated Poria cocos polysaccharide with layer macrophage plasma membrane circumvent MPS sequestration, thereby enhancing therapeutic efficacy nanoparticles. Nanoparticles encapsulated membranes can simulate active homing macrophages lesions during AP, resulting excessive infiltration inflammation sites prolonged tissue retention time. This technique converts non-adhesive lipid into bioadhesive nanoparticles, increasing local accumulation under inflammatory conditions, including pancreas vulnerable lungs. The mechanism related targeting pro-inflammatory macrophages. murine models mild severe intravenous treatment macrophage-mimicking effectively reduces level diminishes recruitment neutrophils. Mechanistic studies elucidate membrane-biomimetic primarily mitigate inhibiting AKT/mTOR pathway reverse autophagic flux impairment. allows us envision biomimetic nanotherapy approach could potentially serve novel for therapy.

Язык: Английский

Процитировано

2
Development of pH-responsive porphyran-coated gold nanorods for tumor photothermal and immunotherapy DOI

Zhen Lin,

Fan Nie,

Jiantong Hou

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133460 - 133460

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

2