Hydrogels for drug delivery

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 437 - 464

Опубликована: Янв. 1, 2025

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Mussel-inspired adhesive and tough hydrogel for drug release based on lignin-containing cellulose nanofiber

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141458 - 141458

Опубликована: Фев. 1, 2025

Язык: Английский

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Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery

Gels, Год журнала: 2025, Номер 11(3), С. 169 - 169

Опубликована: Фев. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Язык: Английский

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Innovative UV‐Responsive Self‐Healing Polyacrylate Coatings for Enhanced Durability in Functional Applications

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

ABSTRACT Polyacrylate was widely used in textiles, leather, and functional coatings due to its excellent film formation flexibility. However, durability compromised by mechanical damage poor water resistance. This study aimed design a UV‐induced self‐healing polyacrylate coating (PXD) using vinyl‐modified coumarin acrylate monomers based on photoreversible covalent hydrophobic interactions. The effect of the structure properties systematically examined. Results showed that increasing polymer chain flexibility, extending distance between structures main chain, raising healing temperature enhanced efficiency. PXD samples achieved over 84% efficiency after 8 h 365 nm UV irradiation at 60°C, with scratches approximately 15 μm wide nearly fully healed within 2 h. Molecular dynamics simulations confirmed influence monomer mechanism clarified. PXD‐5 also exhibited improved hydrophobicity resistance, particularly under light, significantly enhancing leather durability. development represents significant advancement materials.

Язык: Английский

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Enhanced fluorescence of chitosan by grafting pyridine groups and its responsive pH properties

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142079 - 142079

Опубликована: Март 1, 2025

Язык: Английский

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Cyclodextrin-Based Chemically Modified pH-Responsive New Kind of Aldehyde-Functionalized Nanosponge Nanoparticles for Doxorubicin Hydrochloride Delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106853 - 106853

Опубликована: Март 1, 2025

Язык: Английский

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Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the hindered inflammatory microenvironment, and immune cells fail to orchestrate responses Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated enfolded in injectable self-healing hydrogels programmed therapy of wounds through sequentially intrinsically modulating microenvironment promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, regulate broad-spectrum antioxidant activity phenotype regulation, restoring tissue redox homeostasis. Furthermore, can stabilize release engineered exosomes. By integration generation VEGF Exos, secretion M2 macrophages, enhanced binding receptor 2 high affinity sulfated chitosan, intrinsic immunomodulatory effectively promote accelerate healing process.

Язык: Английский

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Constructing Reinforced Flexible Wood-Based Hydrogels Leveraging the Ordered Structure of Wood for Potential Wound Treatment

ACS Sustainable Chemistry & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

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A facile injectable and self-healing carbon dot/oxidative polysaccharide hydrogel with sustained release capability and potent antibacterial activity

Journal of Materials Science, Год журнала: 2024, Номер 59(28), С. 13090 - 13102

Опубликована: Июль 1, 2024

Язык: Английский

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On-Demand Removable Chitosan Based Self-Healing and Antibacterial Hydrogel for Delivery of Tetracycline and Curcumin As Potential Wound Dressing Material

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Wound care is a flourishing branch of healthcare wherein great amount research devoted to develop competent wound dressings. Safe, cost-effective, and biocompatible dressings aid in healing without inflicting external trauma subsequent scar formation. Toward this, we have attempted robust dressing material with self-healing antibacterial properties. We cross-linked chitosan 4-formyl phenylboronic acid (4-FPBA) situ generated dehydroascorbic (DHA) utilizing the dynamic imine boronate ester linkages. Displaying channeled microstructure SEM micrographs, hydrogel exhibits massive water uptake capacity ∼900% at acidic pH. The could completely self-heal within 3 min, results are further supported by rheological analysis. By virtue positive surface charge, it shows promising tissue adhesive property. Moreover, affords clean compliant removal from via dissolution induced dopamine potentially reduce secondary scarring peeling significantly act against skin infections caused

Язык: Английский

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