Enhancing PLA Filament Biocompatibility by introducing ZnO and Ketoprofen DOI

Thalita Silva Neto,

Lana S. Maia, M.O.T. da Conceição

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 22, 2024

Abstract This study investigates the incorporation of zinc oxide (ZnO) and ketoprofen (keto) into poly(lactic acid) (PLA) filaments to enhance their biocompatible. PLA is widely used in additive manufacturing, especially biomedical applications, due its biodegradability biocompatibility. However, interaction with biological tissues can be improved. ZnO was chosen for wound-healing properties, while keto, a nonsteroidal anti-inflammatory drug, selected provide local effects. were prepared by incorporating followed analyses mechanical, thermal, properties. The results showed that keto did not compromise mechanical thermal properties filaments. Compared pristine PLA, composites presented slight improvement strength. composite increased stability compared PLA-ZnO filament. Concerning morphology, when Keto inserted, scaffold acquired more robust structure, well-defined porosity. In vitro biocompatibility tests indicated modified exhibited lower cellular toxicity improved cell adhesion proliferation pure PLA. Antimicrobial demonstrated containing ZnO, at evaluated concentration, exhibit activity against Staphylococcus aureus, Escherichia coli Pseudomonas aeruginosa, gram-positive gram-negative bacteria. combination providing better without compromising intrinsic characteristics work paves way development safer effective medical implants devices.

Язык: Английский

Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies DOI Creative Commons
Rouyan Chen, Jasmine Sarah Pye, Jiarong Li

и другие.

Bioactive Materials, Год журнала: 2023, Номер 27, С. 505 - 545

Опубликована: Апрель 28, 2023

Osteochondral defects are caused by injury to both the articular cartilage and subchondral bone within skeletal joints. They can lead irreversible joint damage increase risk of progression osteoarthritis. Current treatments for osteochondral injuries not curative only target symptoms, highlighting need a tissue engineering solution. Scaffold-based approaches be used assist regeneration, where biomaterials tailored properties restore defect minimise further degeneration. This review captures original research studies published since 2015, on multiphasic scaffolds treat in animal models. These an extensive range scaffold fabrication, consisting mainly natural synthetic polymers. Different methods were create designs, including integrating or fabricating multiple layers, creating gradients, through addition factors such as minerals, growth factors, cells. The variety animals model defects, rabbits most commonly chosen vast majority reported small rather than large few available clinical reporting cell-free have shown promising early-stage results repair, but long-term follow-up is necessary demonstrate consistency restoration. Overall, preclinical show favourable simultaneously regenerating models suggesting that biomaterials-based strategies may

Язык: Английский

Процитировано

45
Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability DOI
Narsimha Mamidi,

Fátima Franco De Silva,

Alejandro Bedón Vacas

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(27)

Опубликована: Июнь 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Язык: Английский

Процитировано

25
Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications DOI Creative Commons
Arnaud Kamdem Tamo

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(32), С. 7692 - 7759

Опубликована: Янв. 1, 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Язык: Английский

Процитировано

22
Design of bone scaffolds with calcium phosphate and its derivatives by 3D printing: A review DOI

Seyedeh Farnaz Darghiasi,

Ashkan Farazin,

Hanieh Sadat Ghazali

и другие.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2024, Номер 151, С. 106391 - 106391

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

19
A tough, stretchable, adhesive and electroconductive polyacrylamide hydrogel sensor incorporated with sulfonated nanocellulose and carbon nanotubes DOI

Wangfang Deng,

Yidong Zhang, Meiyan Wu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135165 - 135165

Опубликована: Авг. 31, 2024

Язык: Английский

Процитировано

7
Biomimetic design of platelet-rich plasma controlled release bacterial cellulose/hydroxyapatite composite hydrogel for bone tissue engineering DOI
Xiangmei Wang, Xiaoli Yang, Xin Xiao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132124 - 132124

Опубликована: Май 7, 2024

Язык: Английский

Процитировано

4
Review: smart and active hydrogels in biotechnology—synthetic techniques and applications DOI
Shanza Rauf Khan,

Laiba Maryam,

Asma Gulzar

и другие.

Journal of Materials Science, Год журнала: 2024, Номер 59(35), С. 16449 - 16471

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4
Poly(dopamine) nanoparticles-reinforced bacterial cellulose-fungal carboxymethyl chitosan nanocomposite hydrogel for wearable strain sensing DOI
Maduru Suneetha, Sarah Alshehri, Sung Soo Han

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136354 - 136354

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
nano-HA and Gel Improves Mechanical Performance and Biomineralization of 3D-printed nano-HA/Gel/CMC Bone Scaffolds DOI Creative Commons
Şule Arıcı, Ali E. Guven,

Hatice Kaya

и другие.

Nano Trends, Год журнала: 2025, Номер unknown, С. 100097 - 100097

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Functionalization of Bacterial Nanocellulose-based Wound Dressing for Increased Drug Retention DOI Creative Commons
Troy C. Breijaert, Marina de Lima Fontes,

Paula de Abreu Fernandes

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100756 - 100756

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0