Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN
Journal of Diabetes,
Год журнала:
2025,
Номер
17(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes
with
complex
pathogenesis.
Methods
Recent
studies
were
reviewed
to
explore
the
role
gut
microbiota
and
its
metabolites
in
DN
development.
Results
Dysbiosis
bacteria
contributes
pathological
changes
such
as
glomerular
sclerosis
renal
tubule
injury.
Microbial
are
involved
through
immune
inflammatory
pathways.
Conclusions
Understanding
relationship
between
microbiota,
metabolites,
may
offer
potential
implications
for
diagnosis,
prevention,
treatment.
Translating
this
knowledge
into
clinical
practice
presents
challenges
opportunities.
Язык: Английский
Synergistic Modification of Carrageenan Films with Plasticizers and Cross-Linker: A Promising Approach to Tunable Functionalities
ACS Applied Polymer Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Язык: Английский
Application of fucoidan for the encapsulation of yeast K2 toxin
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2024,
Номер
7, С. 100521 - 100521
Опубликована: Май 28, 2024
Fucoidan
is
an
anionic
polysaccharide
derived
from
brown
algae
and
composed
of
L-fucose
residues
linked
by
alternating
α-(1→3)
with
α-(1→4)
linkages
or
either
alone.
known
for
its
pharmacological,
antibacterial,
antifungal
properties
used
in
the
food
industry.
The
aim
study
was
to
apply
fucoidan
formulation
yeast
killer
toxin
K2
produced
Saccharomyces
cerevisiae.
toxin-loaded
particles
were
formed
a
low-cost
complexation
method.
They
characterised
dynamic
light
scattering,
FT-IR
spectroscopy,
scanning
electron
microscopy
methods.
ranged
size
180
280
nm
stable
at
least
one
month
4°C.
encapsulated
retained
antimicrobial
activity.
In
addition,
increased
stability
room
temperature.
could
serve
as
carrier
enhance
biotechnological
potential
agents
S.
Encapsulation
opens
up
opportunities
use
beverage
industry
biopreservation.
Язык: Английский
A novel arabinogalactan extracted from Epiphyllum oxypetalum (DC.) Haw improves the immunity and gut microbiota in cyclophosphamide‐induced immunosuppressed mice
eFood,
Год журнала:
2024,
Номер
5(5)
Опубликована: Окт. 1, 2024
Abstract
A
novel
type
I
arabinogalactan
(AG‐I)
polysaccharide
(EPS)
from
Epiphyllum
oxypetalum
(DC.)
Haw
's
flowers
is
hypothesized
to
possess
immunomodulatory
activity.
This
study
investigated
EPS's
effects
on
immune
functions
and
its
potential
mechanism
for
enhancing
intestinal
health
in
immunosuppressed
mice.
The
results
showed
that
supplementing
EPS
significantly
alleviated
organ
damage,
increased
the
thymus
index
(
p
<
0.01),
regulated
key
factors,
including
tumor
necrosis
factor‐alpha
(TNF‐α),
immunoglobulin
(IgA),
complement
3
(C3)
liver
0.05).
promoted
expression
of
barrier
chemical
proteins
such
as
interferon‐γ
(IFN‐γ)
mucin
2
(MUC2)
0.05),
effectively
repairing
damage.
improved
diversity
structure
microbiota
mice
0.05)
altered
abundance
immune‐related
microbial
taxa,
Lactobacillaceae
Lactobacillus
0.01).
Furthermore,
supplementation
lactic
acid
metabolism,
increasing
levels
by
up
3.4‐fold
enhanced
Gpr81,
Wnt3a,
β‐catenin
at
bottom
colonic
crypts,
which
may
repair
physical
barrier.
Overall,
represents
a
AG‐I
dietary
enhances
immunity
improves
gut
health.
Язык: Английский