Materials Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Antimicrobial peptide loaded biomaterial inks for 3D printing can fabricate personalised medical devices that has significant healthcare benefits given the lower risk infection related failure and tendency to develop antimicrobial resistant bacteria.
Язык: Английский
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Дек. 1, 2024
ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.
Язык: Английский
Процитировано
3
Materials, Год журнала: 2025, Номер 18(5), С. 1125 - 1125
Опубликована: Март 2, 2025
We herein demonstrate the utility of gelatin methacryloyl (GelMA)/poly(ethylene glycol) diacrylate (PEGDA)-cerium oxide (CeO2) hydrogel inks for manufacturing scaffolds with antimicrobial efficacy by vat photopolymerization. For uniform blending GelMA/PEGDA hydrogels, CeO2 nanoparticles a round shape were synthesized precipitation method coupled calculation at 600 °C. In addition, they had highly crystalline phases and desired chemical structures (oxidation states Ce3+ Ce4+) required outstanding efficacy. A range GelMA/PEGDA-CeO2 different contents (0% w/v, 0.1% 0.5% 1% 5% w/v respect to distilled water content) manufactured. The photopolymerization behavior, mechanical properties, biological properties (swelling biodegradation behaviors) characterized optimize content. produced highest content (5% w/v) showed reasonable (compressive strength = 0.56 ± 0.09 MPa compressive modulus 0.19 0.03 MPa), high swelling ratio (1063.3 10.9%), rate (remaining weight after 28 days 39.6 2.3%). Furthermore, (the number colony-forming units 76 44.6 (×103)). macroporous tightly controlled porous could be manufactured
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Язык: Английский
Процитировано
0
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
ABSTRACT Chronic wound healing is often compromised by bacterial infection, and pH changes strongly correlate with infection. Therefore, the development of dressings capable real‐time monitoring, antimicrobial activity, tissue repair crucial for effective management infected chronic wounds. This study reports a novel multifunctional composite hydrogel (GM‐C‐mBG@P) synthesized incorporating microwave‐synthesized carbon quantum dots (CQDs) polydopamine‐modified mesoporous bioactive glass nanoparticles (mBG@P) into modified gelatin methacryloyl (GelMA). The incorporated polydopamine (PDA) confers excellent photothermal properties to hydrogel, enabling activity. Under 360 nm UV excitation, fluorescence intensity CQDs in GM‐C‐mBG@P exhibits strong linear correlation pH, monitoring. Furthermore, mBG@P can gradually dissolve calcium, silicon, boron, other functional ions enhance bioactivity functionality accelerate healing. These findings suggest that has potential serve as promising dressing treatment
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(5), С. 345 - 345
Опубликована: Май 6, 2025
Compared with acute wounds, typical chronic wounds (infection, burn, and diabetic wounds) are susceptible to bacterial infection hard heal. As for the complexity of biocompatible hydrogel dressings can be employed regulate microenvironment accelerate wound healing their controllable physical chemical properties. Recently, various nanomaterials have been introduced into networks prepare functional nanocomposite hydrogels. Among them, carbon-based (CBNs) attracted wide attention in biomedical field due outstanding physicochemical However, comprehensive reviews on use CBNs multifunctional past 10 years very scarce. This review focuses research progress made CBNs. Specifically, a series (carbon dots, graphene quantum fullerenes, nanodiamonds, carbon nanotubes, graphene, oxide reduced oxide) preparation hydrogels described as well (CBNHs) versatility (conductivity, antibacterial, injectable self-healing, anti-inflammatory antioxidant properties, substance delivery, stimulus response real-time monitoring). Moreover, applications CBNHs treating different concretely discussed. may provide some new inspirations future development care tissue engineering.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144638 - 144638
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Апрель 10, 2024
Hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process. However, it remains a challenge to fabricate hydrogel that simultaneously exhibit excellent mechanical photothermal antibacterial properties. Here we report development of polydopamine-functionalized graphene oxide/calcium alginate/Polypyrrole cotton fabric-reinforced hydrogels (abbreviated as rGO@PDA/CA/PPy FHs) for tackling bacterial infections. The properties were greatly enhanced by fabric reinforcement an interpenetrating structure, while broad-spectrum based on effect obtained incorporating PPy rGO@PDA. Results indicated FHs exhibited superior tensile strength both warp (289±62.1N) weft directions (142±23.0N) similar fabric. By rGO@PDA, swelling ratio was significantly decreased from 673.5% 236.6%, conversion performance with temperature elevated 45.0 ℃. Due synergistic rGO@PDA PPy, bacteria-eliminating efficiency S. aureus (0.57%) E. coli (3.58%) after exposure NIR 20 min. We believe design could serve guideline developing improved infected treatment.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131895 - 131895
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
2
ACS Nanoscience Au, Год журнала: 2024, Номер 4(4), С. 263 - 272
Опубликована: Июнь 7, 2024
While the continuous development of advanced bioprinting technologies is under fervent study, enhancing regenerative potential hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, remodeling. This study explores synergistic interplay between photothermal activity nanomaterial-mediated cell proliferation. The use graphene-based materials (GBM) photoactive bioinks investigated. In particular, we report creation skin-inspired medicine. Three distinct GBM, namely, graphene oxide (GO), reduced (rGO), platelets (GP), were rigorously characterized, their capabilities elucidated. Our investigations revealed that rGO exhibited highest efficiency antibacterial properties when irradiated, even concentration as low 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based alongside fibroblasts employed with rGO. scaffold did not affect survival 3 days after bioprinting, viability was affected. Remarkably, inclusion compromise printability hydrogel, ensuring successful fabrication complex constructs. Furthermore, presence final continued provide benefits antimicrobial therapy detrimentally affecting growth. outcome underscores rGO-enhanced hydrogels engineering medicine applications. findings hold promise developing game-changer strategies 4D create smart functional high proliferation promising therapeutic drug delivery bactericidal dressings.
Язык: Английский
Процитировано
2
Materials Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Antimicrobial peptide loaded biomaterial inks for 3D printing can fabricate personalised medical devices that has significant healthcare benefits given the lower risk infection related failure and tendency to develop antimicrobial resistant bacteria.
Язык: Английский
Процитировано
1