Journal of Biomedical Materials Research Part A,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Effectively
managing
inflammatory
bowel
disease
(IBD)
poses
difficulties
due
to
its
persistent
nature
and
unpredictable
episodes
of
exacerbation.
There
is
encouraging
evidence
that
personalized
medication
delivery
systems
can
improve
therapy
efficacy
while
reducing
the
negative
effects
standard
medicines.
Zein,
a
protein
produced
from
corn,
has
garnered
interest
as
possible
means
delivering
drugs
for
treatment
IBD.
This
review
delves
into
Zein-based
drug
systems,
showcasing
biodegradability,
controlled
release
capabilities,
biocompatibility.
Studies
have
shown
nanoparticles,
microcarriers,
core-shell
microparticles
capacity
increase
stability,
enhance
targeting
in
intestines,
decrease
toxicity
animal
models
The
highlights
promise
Zein
IBD
urges
more
study
clinical
use.
Abstract
The
growing
population
and
the
unpalatable
ecological
impact
of
exploration
utilization
fossil-based
fuels
have
resulted
in
increased
demand
for
biofuel
as
an
alternative
fuel
engines
power
generation.
global
biodiesel,
a
prominent
member
biofuels
family,
has
continued
to
increase
over
past
decades
with
researchers
devising
various
means
intensify
cost-effective
production.
use
metal
oxide
nanocatalysts
is
one
feasible
strategies
meet
quality
biodiesel.
This
study
reviews
recent
advances
deployment
commonly
used
nanoparticles
such
MgO,
CaO,
TiO
2
,
ZnO,
ZrO
accelerate
sustainable
biodiesel
Converting
conventional
heterogeneous
catalysts
into
enhances
surface
configuration,
chemical
thermal
stability,
porosity,
crystallinity
nanocatalysts.
hasten
transesterification
reaction,
reduces
reaction
temperature
time,
yield.
Biodiesel
synthesized
aid
impeccable
meets
international
standards.
Notwithstanding
few
challenges,
application
engenders
production
contributes
energy
security.
More
innovative
collaborative
studies
are
needed
reduce
ethical,
economic,
infrastructural,
environmental
consequences
usage
nanomaterials
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 22, 2025
Abstract
Electrospun
functional
nanofibers
enable
controlled
release
of
the
loaded
active
ingredient
and
an
adjustable
dissolution
rate.
However,
widespread
use
toxic
organic
solvents
in
electrospinning
poses
risks
to
human
health
environment
whereas
increasing
production
costs
complexity.
This
article
examines
application
eco‐friendly
technologies
food
engineering,
with
a
focus
on
water‐based
melt
methods.
It
provides
detailed
analysis
water‐soluble
biopolymers
synthetic
polymers,
highlighting
their
current
applications
challenges
engineering.
Water‐based
is
proposed
as
sustainable
alternative,
offering
scalability
reduced
environmental
impact.
transition
essential
for
advancing
engineering
toward
more
environmentally
responsible
practices.
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 800 - 800
Опубликована: Авг. 7, 2024
The
advent
of
pH-sensitive
liposomes
(pHLips)
has
opened
new
opportunities
for
the
improved
and
targeted
delivery
antitumor
drugs
as
well
gene
therapeutics.
Comprising
fusogenic
dioleylphosphatidylethanolamine
(DOPE)
cholesteryl
hemisuccinate
(CHEMS),
these
nanosystems
harness
acidification
in
tumor
microenvironment
endosomes
to
deliver
effectively.
pH-responsive
that
are
internalized
through
endocytosis
encounter
mildly
acidic
pH
thereafter
fuse
or
destabilize
endosomal
membrane,
leading
subsequent
cargo
release
into
cytoplasm.
extracellular
matrix
also
presents
a
slightly
environment
can
lead
enhanced
drug
targeting
capabilities
nano-delivery
system.
Recent
studies
have
shown
folic
acid
(FA)
iRGD-coated
nanocarriers,
including
liposomes,
preferentially
accumulate
breast
tumors
overexpress
folate
receptors
αvβ3
αvβ5
integrins.
This
study
focuses
on
development
characterization
5-Fluorouracil
(5-FU)-loaded
FA
iRGD
surface-modified
pHLips
(FA-iRGD-5-FU-pHLips).
novelty
this
research
lies
dual
mechanism
utilizing
peptides,
combined
with
properties
enhance
selective
uptake
by
cancer
cells
effective
environment.
prepared
were
small,
an
average
diameter
152
±
3.27
nm,
uniform,
unilamellar,
demonstrating
efficient
5-FU
encapsulation
(93.1
2.58%).
Despite
surface
functionalization,
maintained
their
sensitivity
neutral
zeta
potential,
which
conferred
stability
reduced
aggregation.
Effective
responsiveness
was
demonstrated
observation
at
5.5
compared
physiological
7.4.
(84.47%
versus
46.41%
7.4,
respectively,
72
h).
formulations
exhibited
six
months
stable
when
subjected
simulated
biological
settings.
Blood
compatibility
cytotoxicity
MDA-MB-231
SK-BR3
cell
lines
revealed
liposomal
formulation
modified
free
minimal
hemolysis.
Collectively,
findings
support
potential
surface-camouflaged,
promising
strategy
treatment.
Coatings,
Год журнала:
2025,
Номер
15(1), С. 79 - 79
Опубликована: Янв. 13, 2025
In
the
present
study,
an
electrospinning
freshness
monitoring
film
prepared
by
gelatin/zein
loading
with
purple
sweet
potato
anthocyanins
(PSPA)
was
produced
to
track
state
of
Penaeus
vannamei.
The
electrospun
nanofiber
films
gelatin
and
zein
weight
ratio
1:0,
3:1,
2:1,
1:1
were
named
GA,
GZA
1:1,
respectively.
impacts
concentration
on
properties
investigated.
SEM
results
showed
that
a
smooth
surface
observed
for
films.
As
content
increased,
average
diameter
decreased.
No
new
characteristic
peaks
shown
FTIR
XRD,
indicating
good
compatibility
between
gelatin,
zein,
PSPA.
incorporation
decreased
swelling
(from
completely
dissolved
100.7%)
water
solubility
100%
30%)
increased
contact
angle
0°
113.3°).
had
apparent
color
changes
NH3
demonstrated
stability
reversibility.
Furthermore,
states
(fresh,
sub-fresh,
spoiled)
vannamei
storage
at
4
°C
could
be
effectively
distinguished
3:1
showing
different
colors
pink
grayish
blue).
Consequently,
GZA3:1
exhibited
improved
hydrophobicity
pH
sensitivity
has
great
potential
in
real-time
aquatic
product
quality.
